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Phosphodiesterase 3D structures
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**[[1f0j]] – mPDE 2a regulatory domain (mutant) – mouse<BR /> | **[[1f0j]] – mPDE 2a regulatory domain (mutant) – mouse<BR /> | ||
**[[1z1l]], [[3ibj]], [[3itm]] - hPDE 2a catalytic domain<BR /> | **[[1z1l]], [[3ibj]], [[3itm]] - hPDE 2a catalytic domain<BR /> | ||
| - | **[[3itu]], [[4htx]], [[4htz]], [[4jib]], [[4d08]], [[4d09]], [[5xkm]], [[5vp0]], [[5vp1]], [[5u7l]], [[5u7k]], [[5u7j]], [[5u7i]], [[5u7d]], [[5u00]], [[5tzz]], [[5tzx]], [[5tzw]], [[5tzh]], [[5tzc]], [[5tza]], [[5tz3]], [[6ezf]], [[6c7j]], [[6c7i]], [[6c7g]], [[6c7f]], [[6c7e]], [[6c7d]], [[6b98]], [[6b97]], [[6b96]], [[4c1i]], [[6cyd]], [[6cyc]], [[6cyb]], [[6blf]] - hPDE 2a catalytic domain + inhibitor<br /> | + | **[[3itu]], [[4htx]], [[4htz]], [[4jib]], [[4d08]], [[4d09]], [[5xkm]], [[5vp0]], [[5vp1]], [[5u7l]], [[5u7k]], [[5u7j]], [[5u7i]], [[5u7d]], [[5u00]], [[5tzz]], [[5tzx]], [[5tzw]], [[5tzh]], [[5tzc]], [[5tza]], [[5tz3]], [[6ezf]], [[6c7j]], [[6c7i]], [[6c7g]], [[6c7f]], [[6c7e]], [[6c7d]], [[6b98]], [[6b97]], [[6b96]], [[4c1i]], [[6cyd]], [[6cyc]], [[6cyb]], [[6blf]], [[6znd]] - hPDE 2a catalytic domain + inhibitor<br /> |
**[[1f0j]] – mPDE 2a regulatory domain (mutant) – mouse<BR /> | **[[1f0j]] – mPDE 2a regulatory domain (mutant) – mouse<BR /> | ||
**[[6cpu]] - CaPDE 2 – ''Candida albicans''<br /> | **[[6cpu]] - CaPDE 2 – ''Candida albicans''<br /> | ||
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*PDE 3 | *PDE 3 | ||
| + | **[[7l27]] – hPDE 3a <br /> | ||
| + | **[[7l29]] – hPDE 3a + AMP <br /> | ||
| + | **[[7kwe]] – hPDE 3a + DNMDP <br /> | ||
| + | **[[7l28]] – hPDE 3a + trequinsin <br /> | ||
| + | **[[7eg0]], [[7eg1]], [[7eg4]], [[7lrc]], [[7lrd]] – hPDE 3a + SLFN12 – Cryo EM <br /> | ||
**[[1so2]], [[1soj]] – hPDE 3b catalytic domain + inhibitor<br /> | **[[1so2]], [[1soj]] – hPDE 3b catalytic domain + inhibitor<br /> | ||
**[[5z7c]] – PDE 3 (mutant) – ''Vibrio cholerae'' <br /> | **[[5z7c]] – PDE 3 (mutant) – ''Vibrio cholerae'' <br /> | ||
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**[[1xot]] - hPDE 4b catalytic domain + drug<br /> | **[[1xot]] - hPDE 4b catalytic domain + drug<br /> | ||
**[[1tb5]], [[1ro9]], [[1ror]] - hPDE 4b catalytic domain + AMP<BR /> | **[[1tb5]], [[1ro9]], [[1ror]] - hPDE 4b catalytic domain + AMP<BR /> | ||
| - | **[[1y2h]], [[1y2j]], [[2qyl]], [[3d3p]], [[3kkt]], [[3frg]], [[3gwt]], [[3ly2]], [[3hmv]], [[3o56]], [[3o57]], [[3o0j]], [[3w5e]], [[3wd9]], [[4myq]], [[4kp6]], [[4nw7]], [[5k6j]], [[5ohj]], [[5laq]] - hPDE 4b catalytic domain + inhibitor<br /> | + | **[[1y2h]], [[1y2j]], [[2qyl]], [[3d3p]], [[3kkt]], [[3frg]], [[3gwt]], [[3ly2]], [[3hmv]], [[3o56]], [[3o57]], [[3o0j]], [[3w5e]], [[3wd9]], [[4myq]], [[4kp6]], [[4nw7]], [[5k6j]], [[5ohj]], [[5laq]], [[8oeg]] - hPDE 4b catalytic domain + inhibitor<br /> |
**[[4x0f]] - hPDE 4b catalytic domain (mutant) + inhibitor<br /> | **[[4x0f]] - hPDE 4b catalytic domain (mutant) + inhibitor<br /> | ||
**[[3g45]] - hPDE 4b catalytic domain + modulator | **[[3g45]] - hPDE 4b catalytic domain + modulator | ||
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**[[2qym]] – hPDE 4c catalytic domain | **[[2qym]] – hPDE 4c catalytic domain | ||
| - | *PDE 4d or cAMP-specific 3’5’-cyclic PDE 4d | + | *PDE 4d or cAMP-specific 3’5’-cyclic PDE 4d |
**[[1e9k]] - hPDE 4d5 N terminal – NMR<BR /> | **[[1e9k]] - hPDE 4d5 N terminal – NMR<BR /> | ||
**[[1mkd]], [[1oyn]], [[1q9m]], [[1tbb]], [[1xoq]], [[3g4k]], [[3g4l]] - hPDE 4d catalytic domain + anti-inflammatory drug<br /> | **[[1mkd]], [[1oyn]], [[1q9m]], [[1tbb]], [[1xoq]], [[3g4k]], [[3g4l]] - hPDE 4d catalytic domain + anti-inflammatory drug<br /> | ||
| - | **[[1xlx]], [[1xlz]], [[1xm4]], [[1xm6]], [[1xmu]], [[1xom]], [[1xon]], [[1xor]], [[1xos]], [[3iak]] - hPDE 4d catalytic domain + drug<br /> | + | **[[1xlx]], [[1xlz]], [[1xm4]], [[1xm6]], [[1xmu]], [[1xom]], [[1xon]], [[1xor]], [[1xos]], [[3iak]], [[6akr]], [[6kjz]], [[6kk0]], [[6lrm]], [[7cbq]] - hPDE 4d catalytic domain + drug<br /> |
**[[1ptw]], [[1tb7]] - hPDE 4d catalytic domain + AMP<BR /> | **[[1ptw]], [[1tb7]] - hPDE 4d catalytic domain + AMP<BR /> | ||
**[[2pw3]] - hPDE 4d catalytic domain (mutant) + AMP<BR /> | **[[2pw3]] - hPDE 4d catalytic domain (mutant) + AMP<BR /> | ||
| - | **[[1y2b]], [[1y2c]], [[1y2d]], [[1y2e]], [[1y2k]], [[1zkn]], [[2fm0]], [[2fm5]], [[2qyn]], [[3k4s]], [[3sl3]], [[3sl4]], [[3sl5]], [[3sl6]], [[3sl8]], [[3v9b]], [[5wqa]], [[5tkb]], [[5k32]], [[5k1i]], [[4wcu]], [[4w1o]], [[4ogb]], [[6fdc]], [[6f8x]], [[6f8w]], [[6f8v]], [[6f8u]], [[6f8t]], [[6f8r]], [[6f6u]], [[5wh6]], [[5wh5]], [[5lbo]], [[6rcw]], [[6inm]], [[6ink]], [[6ind]], [[6imt]], [[6imr]], [[6imo]], [[6imd]], [[6imi]], [[6imb]], [[6im6]], [[6hwo]], [[6fw3]], [[6ftw]], [[6fta]], [[6ft0]], [[6fet]], [[6feb]], [[6fe7]], [[6fdi]], [[6boj]] - hPDE 4d catalytic domain + inhibitor<br /> | + | **[[1y2b]], [[1y2c]], [[1y2d]], [[1y2e]], [[1y2k]], [[1zkn]], [[2fm0]], [[2fm5]], [[2qyn]], [[3k4s]], [[3sl3]], [[3sl4]], [[3sl5]], [[3sl6]], [[3sl8]], [[3v9b]], [[5wqa]], [[5tkb]], [[5k32]], [[5k1i]], [[4wcu]], [[4w1o]], [[4ogb]], [[6fdc]], [[6f8x]], [[6f8w]], [[6f8v]], [[6f8u]], [[6f8t]], [[6f8r]], [[6f6u]], [[5wh6]], [[5wh5]], [[5lbo]], [[6rcw]], [[6inm]], [[6ink]], [[6ind]], [[6imt]], [[6imr]], [[6imo]], [[6imd]], [[6imi]], [[6imb]], [[6im6]], [[6hwo]], [[6fw3]], [[6ftw]], [[6fta]], [[6ft0]], [[6fet]], [[6feb]], [[6fe7]], [[6fdi]], [[6boj]], [[6iag]], [[6ibf]], [[6zba]], [[7a8q]], [[7a9v]], [[7aag]], [[7ab9]], [[7abd]], [[7abe]], [[7abj]], [[7ay6]], [[7b9h]], [[7cbj]], [[7f2k]], [[7f2l]], [[7f2m]], [[7w4x]], [[7w4y]], [[7xaa]], [[7xab]], [[7xbb]], [[7yqf]], [[7ysx]] - hPDE 4d catalytic domain + inhibitor<br /> |
**[[6njj]], [[6nji]], [[6njh]] - hPDE 4d catalytic domain (mutant) + inhibitor<br /> | **[[6njj]], [[6nji]], [[6njh]] - hPDE 4d catalytic domain (mutant) + inhibitor<br /> | ||
**[[3iad]], [[3g4g]], [[3g4i]], [[3g58]] - hPDE 4d catalytic domain + modulator | **[[3iad]], [[3g4g]], [[3g4i]], [[3g58]] - hPDE 4d catalytic domain + modulator | ||
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**[[3lfv]], [[3mf0]], [[2xss]] - hPDE 5a GAF domain<BR /> | **[[3lfv]], [[3mf0]], [[2xss]] - hPDE 5a GAF domain<BR /> | ||
**[[1rkp]], [[3tgg]] – hPDE 5a1 catalytic domain (mutant) + inhibitor<br /> | **[[1rkp]], [[3tgg]] – hPDE 5a1 catalytic domain (mutant) + inhibitor<br /> | ||
| - | **[[2chm]], [[4oex]], [[4oew]], [[4g2w]], [[4g2y]], [[4i9z]], [[4ia0]], [[4md6]], [[5jo3]], [[6acb]], [[5zz2]] - hPDE 5a catalytic domain + inhibitor<br /> | + | **[[2chm]], [[4oex]], [[4oew]], [[4g2w]], [[4g2y]], [[4i9z]], [[4ia0]], [[4md6]], [[5jo3]], [[6acb]], [[5zz2]], [[6iwi]], [[6vbi]], [[7far]] - hPDE 5a catalytic domain + inhibitor<br /> |
**[[2h44]], [[3bjc]], [[3hc8]], [[3hdz]], [[3shy]], [[3shz]], [[3sie]], [[3tge]] - hPDE 5a1 catalytic domain + inhibitor<br /> | **[[2h44]], [[3bjc]], [[3hc8]], [[3hdz]], [[3shy]], [[3shz]], [[3sie]], [[3tge]] - hPDE 5a1 catalytic domain + inhibitor<br /> | ||
| - | **[[1udt]], [[1udu]], [[1uho]], [[1tbf]], [[1xoz]], [[1xp0]], [[2h42]], [[3b2r]] - hPDE 5 catalytic domain + drug<br /> | + | **[[1udt]], [[1udu]], [[1uho]], [[1tbf]], [[1xoz]], [[1xp0]], [[2h42]], [[3b2r]], [[6l6e]] - hPDE 5 catalytic domain + drug<br /> |
**[[3jwq]] - hPDE 5/hPDE 6 catalytic domain + drug<br /> | **[[3jwq]] - hPDE 5/hPDE 6 catalytic domain + drug<br /> | ||
**[[3jwr]] - hPDE 5/hPDE 6 catalytic domain + hPDE γ subunit peptide + inhibitor<br /> | **[[3jwr]] - hPDE 5/hPDE 6 catalytic domain + hPDE γ subunit peptide + inhibitor<br /> | ||
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*PDE 6 or retinal rod rhodopsin-sensitive cGMP 3’,5’-cyclic PDE | *PDE 6 or retinal rod rhodopsin-sensitive cGMP 3’,5’-cyclic PDE | ||
| - | **[[5t4x]] - hPDE 6d δ subunit <br /> | + | **[[5t4x]], [[7pac]] - hPDE 6d δ subunit <br /> |
**[[3t5g]] – hPDE 6d δ subunit + GTP-binding protein RHEB<BR /> | **[[3t5g]] – hPDE 6d δ subunit + GTP-binding protein RHEB<BR /> | ||
**[[3t5i]] - hPDE 6d δ subunit + GTP-binding protein RHEB peptide<br /> | **[[3t5i]] - hPDE 6d δ subunit + GTP-binding protein RHEB peptide<br /> | ||
| - | **[[5tar]], [[5tb5]] - hPDE 6d δ subunit + GTP-binding protein | + | **[[5tar]], [[5tb5]], [[7q9u]] - hPDE 6d δ subunit + GTP-binding protein KRas<br /> |
| + | **[[7qf9]] - hPDE 6d δ subunit + KRas peptide<br /> | ||
**[[5f2u]] - hPDE 6d δ subunit + INPP5E peptide<br /> | **[[5f2u]] - hPDE 6d δ subunit + INPP5E peptide<br /> | ||
**[[5e8f]] - hPDE 6d δ subunit + PDE 6c peptide<br /> | **[[5e8f]] - hPDE 6d δ subunit + PDE 6c peptide<br /> | ||
**[[4jhp]] - hPDE 6d δ subunit + RPGR<br /> | **[[4jhp]] - hPDE 6d δ subunit + RPGR<br /> | ||
| - | **[[4jv6]], [[4jv8]], [[4jvb]], [[4jvf]], [[5ml2]], [[5ml3]], [[5ml4]], [[5ml6]], [[5ml8]], [[5nal]], [[5e80]] - hPDE 6d δ subunit + inhibitor<br /> | + | **[[4jv6]], [[4jv8]], [[4jvb]], [[4jvf]], [[5ml2]], [[5ml3]], [[5ml4]], [[5ml6]], [[5ml8]], [[5nal]], [[5e80]], [[7pad]], [[7pae]], [[7qjk]], [[7faq]] - hPDE 6d δ subunit + inhibitor<br /> |
| - | **[[3dba]] - | + | **[[6mzb]], [[7jsn]] - bPDE 6 g subunit in visual signaling complex – Cryo EM<br /> |
| + | **[[3dba]] - cPDE 6c GAF A domain – chicken<BR /> | ||
| + | **[[6x88]] - cPDE 6c a subunit GAF domain 1-862<br /> | ||
*PDE 7 | *PDE 7 | ||
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**[[3ecm]] – hPDE 8a catalytic domain<BR /> | **[[3ecm]] – hPDE 8a catalytic domain<BR /> | ||
| - | **[[3ecn]] – hPDE 8a catalytic domain + inhibitor<br /> | + | **[[3ecn]], [[7cwf]], [[7cwg]], [[7vsl]], [[7vtv]], [[7vtw]], [[7vtx]] – hPDE 8a catalytic domain + inhibitor<br /> |
| + | **[[7cwa]] - hPDE 8a catalytic domain + leukemia drug<br /> | ||
*PDE 9 | *PDE 9 | ||
| - | **[[2hd1]], [[2yy2]], [[3jsi]], [[3jsw]], [[3k3e]], [[3k3h]], [[4e90]], [[4g2j]], [[4g2l]], [[4gh6]],[[4y8c]], [[4y87]], [[4y86]], [[6a3n]] - hPDE 6d δ subunit + RPGR<br /> | + | **[[2hd1]], [[2yy2]], [[3jsi]], [[3jsw]], [[3k3e]], [[3k3h]], [[4e90]], [[4g2j]], [[4g2l]], [[4gh6]],[[4y8c]], [[4y87]], [[4y86]], [[6a3n]], [[6lzz]], [[[7f0i]], [8bpy]] - hPDE 6d δ subunit + RPGR<br /> |
**[[3n3z]], [[3qi3]], [[3qi4]] - hPDE 9a catalytic domain (mutant) + inhibitor<br /> | **[[3n3z]], [[3qi3]], [[3qi4]] - hPDE 9a catalytic domain (mutant) + inhibitor<br /> | ||
**[[3dy8]], [[3dyl]], [[3dyn]], [[3dyq]], [[3dys]] - hPDE 9 catalytic domain + GMP<br /> | **[[3dy8]], [[3dyl]], [[3dyn]], [[3dyq]], [[3dys]] - hPDE 9 catalytic domain + GMP<br /> | ||
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**[[2zmf]] – hPDE 10a C terminal<BR /> | **[[2zmf]] – hPDE 10a C terminal<BR /> | ||
**[[2ous]], [[2ouv]] - hPDE 10a2 catalytic domain (mutant) <BR /> | **[[2ous]], [[2ouv]] - hPDE 10a2 catalytic domain (mutant) <BR /> | ||
| - | **[[2qyk]], [[3lxg]], [[2y0j]], [[3qpn]], [[3qpo]], [[3qpp]], [[3sn7]], [[3sni]], [[3snl]], [[3wi2]], [[4ael]], [[4ajd]], [[4ajf]], [[4ajg]], [[4ajm]], [[4ddl]], [[4fcb]], [[4fcd]], [[4heu]], [[4hf4]], [[4lkq]], [[4llj]], [[4llk]], [[4llp]], [[4llx]], [[4lm0]], [[4lm1]], [[4lm2]], [[4lm3]], [[4lm4]], [[4muw]], [[4mvh]], [[4yqh]], [[4ys7]], [[3ws8]], [[3ws9]], [[3wyk]], [[3wyl]], [[3wym]], [[4mrw]], [[4mrz]], [[4ms0]], [[4msa]], [[4msc]], [[4mse]], [[4msh]], [[4msn]], [[5uwf]], [[5k9r]], [[5i2r]], [[5edi]], [[5edh]], [[5edg]], [[5ede]], [[5dh5]], [[5dh4]], [[5c2h]], [[5c2e]], [[5c2a]], [[5c29]], [[5c28]], [[5c1w]], [[5b4k]], [[5b4l]], [[5axq]], [[5axp]], [[4zo5]], [[4xy2]], [[4wn1]], [[4tpp]], [[4tpm]], [[4phw]], [[4p1r]], [[4p0n]], [[5xuj]], [[5xui]], | + | **[[2qyk]], [[3lxg]], [[2y0j]], [[3qpn]], [[3qpo]], [[3qpp]], [[3sn7]], [[3sni]], [[3snl]], [[3wi2]], [[4ael]], [[4ajd]], [[4ajf]], [[4ajg]], [[4ajm]], [[4ddl]], [[4fcb]], [[4fcd]], [[4heu]], [[4hf4]], [[4lkq]], [[4llj]], [[4llk]], [[4llp]], [[4llx]], [[4lm0]], [[4lm1]], [[4lm2]], [[4lm3]], [[4lm4]], [[4muw]], [[4mvh]], [[4yqh]], [[4ys7]], [[3ws8]], [[3ws9]], [[3wyk]], [[3wyl]], [[3wym]], [[4mrw]], [[4mrz]], [[4ms0]], [[4msa]], [[4msc]], [[4mse]], [[4msh]], [[4msn]], [[5uwf]], [[5k9r]], [[5i2r]], [[5edi]], [[5edh]], [[5edg]], [[5ede]], [[5dh5]], [[5dh4]], [[5c2h]], [[5c2e]], [[5c2a]], [[5c29]], [[5c28]], [[5c1w]], [[5b4k]], [[5b4l]], [[5axq]], [[5axp]], [[4zo5]], [[4xy2]], [[4wn1]], [[4tpp]], [[4tpm]], [[4phw]], [[4p1r]], [[4p0n]], [[5xuj]], [[5xui]], [[6msc]], [[6msa]], [[6ke0]], [[6kdz]], [[6kdx]], [[6iji]], [[6ijh]], [[5znl]], [[6ko0]], [[6ko1]], [[6kze]], [[7bpi]], [[7qpm]] - hPDE 10a catalytic domain + inhibitor<br /> |
| - | **[[2wey]], [[3hqw]], [[3hqy]], [[3hqz]], [[3hr1]], [[3ui7]], [[3uuo]], [[4bbx]], [[4dff]] - hPDE 10a catalytic domain + schizophrenia drug<br /> | + | **[[2wey]], [[3hqw]], [[3hqy]], [[3hqz]], [[3hr1]], [[3ui7]], [[3uuo]], [[4bbx]], [[4dff]], [[8di4]] - hPDE 10a catalytic domain + schizophrenia drug<br /> |
**[[2oun]] - hPDE 10a2 catalytic domain + AMP<BR /> | **[[2oun]] - hPDE 10a2 catalytic domain + AMP<BR /> | ||
**[[2our]], [[2ouy]] - hPDE 10a2 catalytic domain (mutant) + AMP<BR /> | **[[2our]], [[2ouy]] - hPDE 10a2 catalytic domain (mutant) + AMP<BR /> | ||
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**[[4i15]] – TbPDEb1 catalytic domain – ''Trypanosoma brucei''<br /> | **[[4i15]] – TbPDEb1 catalytic domain – ''Trypanosoma brucei''<br /> | ||
| - | **[[5l9h]], [[5l8y]], [[5l8c]], [[5g5v]], [[5g57]], [[5g2b]], [[4phl]], [[6rgk]], [[6rfw]], [[6rfn]], [[6rb6]], [[6gxq]], [[6fv9]], [[6ftm]], [[6frd]], [[6fe3]], [[6fdx]], [[6fdw]], [[6fds]] – TbPDEb1 catalytic domain + inhibitor<br /> | + | **[[5l9h]], [[5l8y]], [[5l8c]], [[5g5v]], [[5g57]], [[5g2b]], [[4phl]], [[6rgk]], [[6rfw]], [[6rfn]], [[6rb6]], [[6gxq]], [[6fv9]], [[6ftm]], [[6frd]], [[6fe3]], [[6fdx]], [[6fdw]], [[6fds]], [[6qgp]], [[6qgu]], [[7a28]], [[7a2f]] – TbPDEb1 catalytic domain + inhibitor<br /> |
*PDE b2 | *PDE b2 | ||
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**[[2ilx]] - rPDE catalytic domain<BR /> | **[[2ilx]] - rPDE catalytic domain<BR /> | ||
**[[2xmi]], [[2y1p]], [[2y3x]], [[5ae0]] - mPDE catalytic domain <br /> | **[[2xmi]], [[2y1p]], [[2y3x]], [[5ae0]] - mPDE catalytic domain <br /> | ||
| - | **[[4wex]], [[4wdh]], [[4wde]], [[4wdd]], [[4wcc]], [[4wcb]], [[4wca]], [[4wc9]], [[4wbl]], [[4wbi]] - mPDE catalytic domain (mutant) <br /> | + | **[[4wex]], [[4wdh]], [[4wde]], [[4wdd]], [[4wcc]], [[4wcb]], [[4wca]], [[4wc9]], [[4wbl]], [[4wbi]], [[7qzk]], [[7qzs]] - mPDE catalytic domain (mutant) <br /> |
**[[1mc0]] – mPDE regulatory subunit <br /> | **[[1mc0]] – mPDE regulatory subunit <br /> | ||
**[[2ydb]] - mPDE catalytic domain + cyclic NADP<br /> | **[[2ydb]] - mPDE catalytic domain + cyclic NADP<br /> | ||
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**[[1nop]], [[1rff]], [[1rfi]], [[1rg1]], [[1rg2]], [[1rgt]] - hPDE1 catalytic domain (mutant) + DNA + topoisomerase peptide + VO4<BR /> | **[[1nop]], [[1rff]], [[1rfi]], [[1rg1]], [[1rg2]], [[1rgt]] - hPDE1 catalytic domain (mutant) + DNA + topoisomerase peptide + VO4<BR /> | ||
**[[1rgu]], [[1rh0]] - hPDE1 catalytic domain (mutant) + polynucleotide + neurohormone<br /> | **[[1rgu]], [[1rh0]] - hPDE1 catalytic domain (mutant) + polynucleotide + neurohormone<br /> | ||
| - | **[[6n19]], [[6n17]], [[6n0r]], [[6n0o]], [[6n0n]], [[6n0d]], [[6mz0]], [[6myz]], [[6mj5]], [[6djj]], [[6dji]], [[6djh]], [[6djg]], [[6djf]], [[6dje]], [[6djd]], [[6dim]], [[6dih]], [[6die]], [[6dhu]] - hPDE catalytic domain + inhibitor<br /> | + | **[[6n19]], [[6n17]], [[6n0r]], [[6n0o]], [[6n0n]], [[6n0d]], [[6mz0]], [[6myz]], [[6mj5]], [[6djj]], [[6dji]], [[6djh]], [[6djg]], [[6djf]], [[6dje]], [[6djd]], [[6dim]], [[6dih]], [[6die]], [[6dhu]], [[6w4r]], [[6w7j]], [[6w7k]], [[6w7l]], [[7ufy]], [[7ufz]], [[8cvq]], [[8cw2]] - hPDE catalytic domain + inhibitor<br /> |
**[[5j3s]], [[5j3p]] - hPDE catalytic domain (mutant) + inhibitor<br /> | **[[5j3s]], [[5j3p]] - hPDE catalytic domain (mutant) + inhibitor<br /> | ||
**[[5nwa]], [[5nw9]] – hPDE1 residues 1-148 + DNA <br /> | **[[5nwa]], [[5nw9]] – hPDE1 residues 1-148 + DNA <br /> | ||
| + | **[[6q00]], [[6q01]] - hPDE UBA domain 25-66 + ubiquitin<br /> | ||
**[[5j3s]], [[5j3p]] - hPDE1 catalytic domain (mutant) + inhibitor<br /> | **[[5j3s]], [[5j3p]] - hPDE1 catalytic domain (mutant) + inhibitor<br /> | ||
**[[5inm]] - mPDE catalytic domain <br /> | **[[5inm]] - mPDE catalytic domain <br /> | ||
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**[[5t9c]], [[5t9b]] – BsPDE + P3G <br /> | **[[5t9c]], [[5t9b]] – BsPDE + P3G <br /> | ||
**[[5t91]] – BsPDE + bicine<br /> | **[[5t91]] – BsPDE + bicine<br /> | ||
| + | **[[7e0v]] – PfPDE – ''Pyrococcus furiosus''<br /> | ||
| + | **[[7e2a]] – PfPDE (mutant)<br /> | ||
| + | **[[7e2b]] – PfPDE + palmitate + choline<br /> | ||
*PDE | *PDE | ||
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**[[5gz4]] – TacPDE – Taiwan cobra<br /> | **[[5gz4]] – TacPDE – Taiwan cobra<br /> | ||
**[[5gz5]] – TacPDE + AMP <br /> | **[[5gz5]] – TacPDE + AMP <br /> | ||
| + | **[[7cba]] – TacPDE + flavonoid <br /> | ||
**[[2ahd]] – PDE – ''Methanocaldococcus jannaschii''<BR /> | **[[2ahd]] – PDE – ''Methanocaldococcus jannaschii''<BR /> | ||
**[[3qvq]] – PDE + P3G– ''Oleispira antarctica''<br /> | **[[3qvq]] – PDE + P3G– ''Oleispira antarctica''<br /> | ||
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**[[5xsn]] – SaPDE catalytic domain + C-di-AMP<br /> | **[[5xsn]] – SaPDE catalytic domain + C-di-AMP<br /> | ||
**[[5xsp]] – SaPDE catalytic domain + AMP<br /> | **[[5xsp]] – SaPDE catalytic domain + AMP<br /> | ||
| - | **[[5vyd]] – PDE – ''Salpingoeca rosetta''<br /> | + | **[[5vyd]], [[7d7p]] – SrPDE PDE domain 387-704 – ''Salpingoeca rosetta''<br /> |
| + | **[[7cj3]], [[7d7q]] – SrPDE TM domain 33-378<br /> | ||
**[[5o7f]] – TmPDE (mutant) + GMP<br /> | **[[5o7f]] – TmPDE (mutant) + GMP<br /> | ||
**[[5o1u]] – TmPDE + AMP<br /> | **[[5o1u]] – TmPDE + AMP<br /> | ||
**[[5o70]], [[5o4z]] – TmPDE (mutant) + AMP<br /> | **[[5o70]], [[5o4z]] – TmPDE (mutant) + AMP<br /> | ||
**[[5o58]] – TmPDE (mutant) + RNA<br /> | **[[5o58]] – TmPDE (mutant) + RNA<br /> | ||
| + | **[[7dck]] – PDE tw9814 + RNA – ''Epsilonproteobacteria bacterium'' <br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
3D Structures of phosphodiesterase
Updated on 24-August-2023
