Phosphoinositide 3-kinase 3D structures
From Proteopedia
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**[[3mtt]], [[3o5z]] – hPI3KI p85β <br /> | **[[3mtt]], [[3o5z]] – hPI3KI p85β <br /> | ||
**[[2kt1]] - hPI3KI p85β SH3 domain<br /> | **[[2kt1]] - hPI3KI p85β SH3 domain<br /> | ||
| - | **[[3l4q]] – | + | **[[6ox7]], [[6u28]] – hPI3KI p85β + influenza NS1 protein <br /> |
| + | **[[3l4q]] – bPI3KI p85β + influenza NS1 protein <br /> | ||
*'''Class II''' | *'''Class II''' | ||
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**[[3hiz]], [[4jps]] - hTI-PI3K p110α (mutant) + p85α <br /> | **[[3hiz]], [[4jps]] - hTI-PI3K p110α (mutant) + p85α <br /> | ||
**[[2rd0]], [[4l1b]], [[6nct]] - hTI-PI3K p110α + p85α<br /> | **[[2rd0]], [[4l1b]], [[6nct]] - hTI-PI3K p110α + p85α<br /> | ||
| + | **[[7myn]] - hTI-PI3K p110α + p85α – Cryo EM<br /> | ||
**[[5sxk]], [[5sx8]], [[5sx9]], [[5sxa]], [[5sxb]], [[5sxc]], [[5sxd]], [[5sxe]], [[5sxf]], [[5sxi]], [[5sxj]], [[5sw8]], [[5swg]], [[5swo]], [[5swp]], [[5swr]], [[5swt]], [[5dxh]], [[5xgj]], [[5xgi]]], [[5xgh]] - hTI-PI3K p110α + p85α + inhibitor<br /> | **[[5sxk]], [[5sx8]], [[5sx9]], [[5sxa]], [[5sxb]], [[5sxc]], [[5sxd]], [[5sxe]], [[5sxf]], [[5sxi]], [[5sxj]], [[5sw8]], [[5swg]], [[5swo]], [[5swp]], [[5swr]], [[5swt]], [[5dxh]], [[5xgj]], [[5xgi]]], [[5xgh]] - hTI-PI3K p110α + p85α + inhibitor<br /> | ||
**[[5ul1]], [[5ukj]], [[5itd]], [[5fi4]], [[4zop]] - hTI-PI3K p110α (mutant) + p85α + inhibitor<br /> | **[[5ul1]], [[5ukj]], [[5itd]], [[5fi4]], [[4zop]] - hTI-PI3K p110α (mutant) + p85α + inhibitor<br /> | ||
**[[5uk8]] - hTI-PI3K p110α (mutant) + p85α (mutant) + inhibitor<br /> | **[[5uk8]] - hTI-PI3K p110α (mutant) + p85α (mutant) + inhibitor<br /> | ||
| + | **[[7myo]] - hTI-PI3K p110α + p85α + inhibitor – Cryo EM<br /> | ||
**[[4ovu]] - hTI-PI3K p110α + p85α SH2 domain<br /> | **[[4ovu]] - hTI-PI3K p110α + p85α SH2 domain<br /> | ||
**[[4ovv]] - hTI-PI3K p110α + p85α SH2 domain + phosphatidylinositol-4,5-bisphosphate <br /> | **[[4ovv]] - hTI-PI3K p110α + p85α SH2 domain + phosphatidylinositol-4,5-bisphosphate <br /> | ||
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*Type I PI3K p110α | *Type I PI3K p110α | ||
| - | **[[4tuu]], [[4tv3]] - hTI-PI3K p110α<br /> | + | **[[4tuu]], [[4tv3]], [[8bfu]] - hTI-PI3K p110α catalytic subunit 105-1048<br /> |
| - | **[[2enq]] - hTI-PI3K p110α C2 domain<br /> | + | **[[7pg5]] - hTI-PI3K p110α catalytic subunit (mutant) + regulatory subunit 307-593<br /> |
| - | **[[3zim]], [[4a55]], [[4oys]], [[4ph4]], [[4uwf]], [[4uwg]], [[4uwh]], [[4uwk]], [[4uwl]], [[5ubr]], [[5dxt]], [[4ykn]], [[6pys]], [[6oac]], [[6gvi]], [[6gvh]], [[6gvg]], [[6gvf]] - hTI-PI3K p110α + inhibitor<br /> | + | **[[7pg6]], [[7tz7]], [[8sbc]] - hTI-PI3K p110α catalytic subunit (mutant) + regulatory subunit 1-293 inhibitor<br /> |
| + | **[[2enq]] - hTI-PI3K p110α C2 domain 331-481<br /> | ||
| + | **[[6vo7]] - hTI-PI3K p110α RBD 157-300<br /> | ||
| + | **[[3zim]], [[4a55]], [[4oys]], [[4ph4]], [[4uwf]], [[4uwg]], [[4uwh]], [[4uwk]], [[4uwl]], [[5ubr]], [[5dxt]], [[4ykn]], [[6pys]], [[6oac]], [[6gvi]], [[6gvh]], [[6gvg]], [[6gvf]], [[7k6m]], [[7k6n]], [[7k6o]], [[7k71]], [[7mlk]], [[7r9v]], [[7r9y]], [[8exo]], [[8exu]], [[8exv]], [[8sbj]] - hTI-PI3K p110α catalytic subunit + inhibitor<br /> | ||
| + | **[[8ow2]] - hTI-PI3K p110α catalytic subunit + activator <br /> | ||
| + | **[[8exl]] - hTI-PI3K p110α catalytic subunit + drug <br /> | ||
| + | **[[8gua]], [[[8gub]], [[8gud]] - hTI-PI3K p110α catalytic subunit (mutant) + drug – Cryo EM<br /> | ||
| + | **[[8dcp]], [[8dcx]], [[8dd4]], [[8dd8]] - hTI-PI3K p110α catalytic subunit + regulatory subunit 3-724 + nanobody – Cryo EM<br /> | ||
| + | **[[7cio]] - hTI-PI3K p110α C2 domain + CTLA-4<br /> | ||
| + | **[[7bi4]] - mTI-PI3K p110α C2 domain (mutant)<br /> | ||
| + | **[[7bi9]], [[7z74]], [[7z75]], [[8a9i]] - mTI-PI3K p110α C2 domain + inhibitor<br /> | ||
| + | **[[7bi6]] - mTI-PI3K p110α C2 domain + ATP<br /> | ||
*Type I PI3K p110β | *Type I PI3K p110β | ||
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**[[3l08]] – hTI-PI3K p110γ + GSK2126458 <br /> | **[[3l08]] – hTI-PI3K p110γ + GSK2126458 <br /> | ||
**[[3ibe]]– hTI-PI3K p110γ + pyrazolopyrimidine <br /> | **[[3ibe]]– hTI-PI3K p110γ + pyrazolopyrimidine <br /> | ||
| - | **[[3ene]], [[2v4l]], [[2a4z]], [[2a5u]], [[1e7u]], [[1e7v]], [[1e8w]], [[1e8y]], [[1e8z]], [[1e90]], [[1e8x]], [[3tls]], [[3apc]], [[3apd]], [[3apf]], [[3s2a]], [[3r7q]], [[3r7r]], [[3p2b]], [[3mjw]], [[3nzs]], [[3nzu]], [[3qaq]], [[3qar]], [[3zvv]], [[3zw3]], [[3sd5]], [[3t8m]], [[3tl5]], [[4anu]], [[4anv]], [[4anw]], [[4anx]], [[4aof]], [[4dk5]], [[4f1s]], [[4fa6]], [[4fad]], [[4fhj]], [[4fhk]], [[4fjy]], [[4fjz]], [[4flh]], [[4ful]], [[4g11]], [[4gb9]], [[4hle]], [[4hvb]], [[4j6i]], [[4ps3]], [[4ps7]], [[4ps8]], [[4urk]], [[4wwn]], [[4wwo]], [[4wwp]], [[5t23]], [[5kae]], [[5jhb]], [[5jha]], [[5g55]], [[5g2n]], [[5eds]], [[4xz4]], [[4xx5]], [[6gq7]], [[6fh5]], [[6t3b]], [[6t3c]], [[6xrl]], [[6xrm]] – hTI-PI3K p110γ + inhibitor <br /> | + | **[[3ene]], [[2v4l]], [[2a4z]], [[2a5u]], [[1e7u]], [[1e7v]], [[1e8w]], [[1e8y]], [[1e8z]], [[1e90]], [[1e8x]], [[3tls]], [[3apc]], [[3apd]], [[3apf]], [[3s2a]], [[3r7q]], [[3r7r]], [[3p2b]], [[3mjw]], [[3nzs]], [[3nzu]], [[3qaq]], [[3qar]], [[3zvv]], [[3zw3]], [[3sd5]], [[3t8m]], [[3tl5]], [[4anu]], [[4anv]], [[4anw]], [[4anx]], [[4aof]], [[4dk5]], [[4f1s]], [[4fa6]], [[4fad]], [[4fhj]], [[4fhk]], [[4fjy]], [[4fjz]], [[4flh]], [[4ful]], [[4g11]], [[4gb9]], [[4hle]], [[4hvb]], [[4j6i]], [[4ps3]], [[4ps7]], [[4ps8]], [[4urk]], [[4wwn]], [[4wwo]], [[4wwp]], [[5t23]], [[5kae]], [[5jhb]], [[5jha]], [[5g55]], [[5g2n]], [[5eds]], [[4xz4]], [[4xx5]], [[6gq7]], [[6fh5]], [[6q6y]], [[6q73]], [[6q74]], [[6t3b]], [[6t3c]], [[6xrl]], [[6xrm]], [[6xrn]], [[6ykg]], [[7jx0]], [[7kke]], [[7jwz]], [[7rsj]], [[7rsp]], [[7rsv]], [[7z61]] – hTI-PI3K p110γ + inhibitor <br /> |
| - | **[[3tjp]], [[4ezj]], [[4ezk]], [[4ezl]], [[4kz0]], [[4kzc]] - hTI-PI3K p110γ (mutant) + inhibitor<br /> | + | **[[3tjp]], [[4ezj]], [[4ezk]], [[4ezl]], [[4kz0]], [[4kzc]], [[6xrn]], [[6ykg]], [[7jx0]], [[7kke]], [[7jwz]], [[7rsj]], [[7rsp]], [[7rsv]] - hTI-PI3K p110γ (mutant) + inhibitor<br /> |
| + | **[[7jwe]] – hTI-PI3K p110γ + drug<br /> | ||
**[[3dpd]], [[6aud]] – hTI-PI3K p110γ + oxazines inhibitor <br /> | **[[3dpd]], [[6aud]] – hTI-PI3K p110γ + oxazines inhibitor <br /> | ||
**[[3dbs]] – hTI-PI3K p110γ + GDC0941 <br /> | **[[3dbs]] – hTI-PI3K p110γ + GDC0941 <br /> | ||
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**[[3oaw]], [[3ml9]], [[3ml8]], [[3l17]], [[3l16]], [[3l13]], [[3pre]], [[3prz]], [[3ps6]], [[3qjz]], [[3qk0]] – hTI-PI3K p110γ + PI3K/mTOR dual inhibitor<br /> | **[[3oaw]], [[3ml9]], [[3ml8]], [[3l17]], [[3l16]], [[3l13]], [[3pre]], [[3prz]], [[3ps6]], [[3qjz]], [[3qk0]] – hTI-PI3K p110γ + PI3K/mTOR dual inhibitor<br /> | ||
**[[1he8]] - hTI-PI3K p110γ + transforming protein P21/H-RAS-1 effector domain<br /> | **[[1he8]] - hTI-PI3K p110γ + transforming protein P21/H-RAS-1 effector domain<br /> | ||
| + | **[[7mez]] - hTI-PI3K p110 + p101 – cryo EM<br /> | ||
| + | **[[8dp0]] - hTI-PI3K p110 catalytic subunit + nanobody – cryo EM<br /> | ||
| + | **[[8aj8]] - pTI-PI3K p110g catalytic subunit + regulatory subunit - pig<br /> | ||
*Type I PI3K p110δ | *Type I PI3K p110δ | ||
**[[2x38]] – hTI-PI3K p110δ + IC87114 <br /> | **[[2x38]] – hTI-PI3K p110δ + IC87114 <br /> | ||
| - | **[[2wxf]], [[2wxg]], [[2wxh]], [[2wxi]], [[2wxj]], [[2wxk]], [[2wxl]], [[2wxm]], [[2wxn]], [[2wxo]], [[2wxp]], [[2wxq]], [[2wxr]], [[4ajw]] – hTI-PI3K p110δ + inhibitor<br /> | + | **[[2wxf]], [[2wxg]], [[2wxh]], [[2wxi]], [[2wxj]], [[2wxk]], [[2wxl]], [[2wxm]], [[2wxn]], [[2wxo]], [[2wxp]], [[2wxq]], [[2wxr]], [[4ajw]], [[6g6w]], [[6pyr]], [[6pyu]], [[6oco]], [[6ocu]], [[7jis]], [[7jiu]], [[7lm2]] – hTI-PI3K p110δ + inhibitor<br /> |
| + | **[[6dgt]], [[6eyz]], [[6ez6]], [[6ftn]], [[6gy0]], [[6hi1]], [[6hi2]], [[6hi9]], [[6mul]], [[6mum]], [[6tnr]], [[6tns]], [[6zaa]], [[6zac]], [[6zad]], [[7oi4]], [[7oij]] [[7oil]], [[7ois]] [[7pop]], [[7por]], [[7pos]], [[7pot]] – mTI-PI3K p110δ + inhibitor<br /> | ||
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| + | *Type I PI3K p150 | ||
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| + | **[[9c82]] – hTI-PI3K p150 + p100 + ULK1C + C1 – Cryo EM<br /> | ||
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| + | *Type I PI3K p100 | ||
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| + | **[[8sor]] – hTI-PI3K p100 + C1 – Cryo EM<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
3D Structures of PI3K
Updated on 03-July-2024
