7d1x
From Proteopedia
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(New page: '''Unreleased structure''' The entry 7d1x is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)== | |
| + | <StructureSection load='7d1x' size='340' side='right'caption='[[7d1x]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7d1x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D1X FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d1x OCA], [https://pdbe.org/7d1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d1x RCSB], [https://www.ebi.ac.uk/pdbsum/7d1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d1x ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ST2A8_MOUSE ST2A8_MOUSE] Hepatic sulfotransferase involved in the maintenance of bile acid homeostasis and energy balance. Catalyzes the transfer of sulfonate group from 3'-phosphoadenylyl sulfate (PAPS) to the 7-alpha hydroxy group of primary bile acids to form 7-monosulfate derivatives in the pathway of bile acid elimination. Displays high catalytic efficiency toward cholate, chenodeoxycholate and their glycine and taurine conjugates.<ref>PMID:28442498</ref> <ref>PMID:29685090</ref> <ref>PMID:33872606</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Au WNS]] | ||
| + | [[Category: Wang K]] | ||
Current revision
Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)
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