7d20
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7d20 is ON HOLD Authors: Description: Category: Unreleased Structures) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of SET8-CENP-A-nucleosome complex== | |
| + | <StructureSection load='7d20' size='340' side='right'caption='[[7d20]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7d20]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D20 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d20 OCA], [https://pdbe.org/7d20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d20 RCSB], [https://www.ebi.ac.uk/pdbsum/7d20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d20 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Centromere protein 3D structure|Centromere protein 3D structure]] | |
| - | + | *[[Histone 3D structures|Histone 3D structures]] | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Arimura Y]] | ||
| + | [[Category: Ho C-H]] | ||
| + | [[Category: Kobayashi W]] | ||
| + | [[Category: Kurumizaka H]] | ||
| + | [[Category: Takizawa Y]] | ||
Current revision
Cryo-EM structure of SET8-CENP-A-nucleosome complex
| |||||||||||
