1cnt

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[[Image:1cnt.gif|left|200px]]
 
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==CILIARY NEUROTROPHIC FACTOR==
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The line below this paragraph, containing "STRUCTURE_1cnt", creates the "Structure Box" on the page.
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<StructureSection load='1cnt' size='340' side='right'caption='[[1cnt]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cnt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CNT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CNT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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{{STRUCTURE_1cnt| PDB=1cnt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cnt OCA], [https://pdbe.org/1cnt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cnt RCSB], [https://www.ebi.ac.uk/pdbsum/1cnt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cnt ProSAT]</span></td></tr>
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</table>
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'''CILIARY NEUROTROPHIC FACTOR'''
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== Function ==
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[https://www.uniprot.org/uniprot/CNTF_HUMAN CNTF_HUMAN] CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Ciliary neurotrophic factor (CNTF) promotes the survival and differentiation of developing motor neurons and is a potential therapeutic for treating neurodegeneration and nerve injury. The crystal structure of human CNTF has been determined at 2.4 A resolution using multi-wavelength anomalous diffraction (MAD) phasing from a single Yb3+ ions. The structure reveals that CNTF is dimeric, with a novel anti-parallel arrangement of the subunits, not previously observed for other cytokines. Each subunit adopts a double crossover four-helix bundle fold, in which two helices contribute to the dimer interface, whilst two different helices show pronounced kinks. Analysis of the electrostatic surface of CNTF identified residues within these kinked helices that may contact the CNTF receptor-alpha. Solution experiments show that CNTF dimerizes at concentrations &gt; 40 microM. Such dimers are likely to be relevant to the storage of CNTF in the peripheral nerve given the high concentrations present in this tissue. However, it is unlikely that they play a role in engaging the three distinct receptor subunits that comprise the CNTF receptor, given the low concentration of extracellular CNTF and its high potency.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cn/1cnt_consurf.spt"</scriptWhenChecked>
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1CNT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CNT OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing., McDonald NQ, Panayotatos N, Hendrickson WA, EMBO J. 1995 Jun 15;14(12):2689-99. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7796798 7796798]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cnt ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hendrickson, W A.]]
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[[Category: Hendrickson WA]]
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[[Category: Mcdonald, N Q.]]
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[[Category: Mcdonald NQ]]
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[[Category: Panayotatos, N.]]
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[[Category: Panayotatos N]]
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[[Category: Cytokine]]
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[[Category: Growth factor]]
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[[Category: Neurotrophic factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:55:50 2008''
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Current revision

CILIARY NEUROTROPHIC FACTOR

PDB ID 1cnt

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