7k62
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7k62 is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease Description: Crystal Structure of Dihydrofolate reductase from M...) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218== | |
| - | + | <StructureSection load='7k62' size='340' side='right'caption='[[7k62]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7k62]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_kansasii Mycobacterium kansasii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K62 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k62 OCA], [https://pdbe.org/7k62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k62 RCSB], [https://www.ebi.ac.uk/pdbsum/7k62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k62 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A653EQ34_MYCKA A0A653EQ34_MYCKA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium kansasii]] | ||
Current revision
Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218
| |||||||||||
