1rz8

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(New page: 200px<br /> <applet load="1rz8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rz8, resolution 2.30&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:1rz8.gif|left|200px]]<br />
 
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<applet load="1rz8" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1rz8, resolution 2.30&Aring;" />
 
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'''CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B==
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The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds, to the HIV-1 coreceptor is protected from humoral recognition by multiple, layers of camouflage. Here we present sequence and genomic analyses for 12, antibodies that pierce these defenses and determine the crystal structures, of 5. The data reveal mechanisms and atomic-level details for three, unusual immune features: posttranslational mimicry of coreceptor by, tyrosine sulfation of antibody, an alternative molecular mechanism, controlling such sulfation, and highly selective V(H)-gene usage. When, confronted by extraordinary viral defenses, the immune system unveils, novel adaptive capabilities, with tyrosine sulfation enhancing the, vocabulary of antigen recognition.
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<StructureSection load='1rz8' size='340' side='right'caption='[[1rz8]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rz8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZ8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz8 OCA], [https://pdbe.org/1rz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rz8 RCSB], [https://www.ebi.ac.uk/pdbsum/1rz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz8 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rz8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rz8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
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==About this Structure==
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Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.,Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267<ref>PMID:14981267</ref>
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1RZ8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RZ8 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14981267 14981267]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 1rz8" style="background-color:#fffaf0;"></div>
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[[Category: Protein complex]]
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[[Category: Choe, H.]]
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[[Category: Dimitrov, D.S.]]
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[[Category: Farzan, M.]]
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[[Category: Hendrickson, W.A.]]
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[[Category: Huang, C.C.]]
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[[Category: Kwong, P.D.]]
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[[Category: Majeed, S.]]
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[[Category: Moore, M.J.]]
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[[Category: Phogat, S.]]
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[[Category: Robinson, J.]]
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[[Category: Sodroski, J.]]
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[[Category: Venturi, M.]]
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[[Category: Wyatt, R.]]
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[[Category: Zhang, M.Y.]]
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[[Category: hiv-1; gp120; cd4i; antibodies; tyrosine sulfation; vh-gene usage]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov 8 14:27:00 2007''
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Sandbox 20009|Sandbox 20009]]
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*[[3D structures of human antibody|3D structures of human antibody]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Choe H]]
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[[Category: Dimitrov DS]]
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[[Category: Farzan M]]
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[[Category: Hendrickson WA]]
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[[Category: Huang CC]]
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[[Category: Kwong PD]]
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[[Category: Majeed S]]
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[[Category: Moore MJ]]
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[[Category: Phogat S]]
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[[Category: Robinson J]]
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[[Category: Sodroski J]]
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[[Category: Venturi M]]
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[[Category: Wyatt R]]
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[[Category: Zhang M-Y]]

Current revision

CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B

PDB ID 1rz8

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