5inj

<table><tr><td colspan='2'>[[5inj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._rm-5-8 Streptomyces sp. rm-5-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5INJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5INJ FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DST:DIMETHYLALLYL+S-THIOLODIPHOSPHATE'>DST</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5inj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5inj OCA], [http://pdbe.org/5inj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5inj RCSB], [http://www.ebi.ac.uk/pdbsum/5inj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5inj ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.

 

== References ==

[[Category: Streptomyces sp. rm-5-8]]

[[Category: Benach, J]]

[[Category: Cao, H]]

[[Category: Elshahawi, S]]

[[Category: Koss, J W]]

[[Category: Morisco, L L]]

[[Category: NatPro, Enzyme Discovery for Natural Product Biosynthesis]]

[[Category: Phillips, G N]]

[[Category: Thorson, J S]]

[[Category: Wasserman, S R]]

[[Category: Tryptophan]]