3ipx

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Current revision (07:56, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3ipx' size='340' side='right'caption='[[3ipx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3ipx' size='340' side='right'caption='[[3ipx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IPX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ipx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=B86:2-DEOXY-5-FLUOROCYTIDINE'>B86</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ipy|3ipy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=B86:2-DEOXY-5-FLUOROCYTIDINE'>B86</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [https://pdbe.org/3ipx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [https://www.ebi.ac.uk/pdbsum/3ipx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [http://pdbe.org/3ipx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [http://www.ebi.ac.uk/pdbsum/3ipx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipx ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
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[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Deoxycytidine kinase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Carson, K G]]
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[[Category: Carson KG]]
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[[Category: Hoffman, I]]
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[[Category: Hoffman I]]
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[[Category: Hunter, M]]
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[[Category: Hunter M]]
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[[Category: Stouch, T R]]
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[[Category: Stouch TR]]
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[[Category: Swanson, R V]]
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[[Category: Swanson RV]]
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[[Category: Tari, L W]]
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[[Category: Tari LW]]
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[[Category: Atp-binding]]
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[[Category: Human deoxycytidine kinase]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor

PDB ID 3ipx

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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