5tjx

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Current revision (13:03, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5tjx' size='340' side='right'caption='[[5tjx]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
<StructureSection load='5tjx' size='340' side='right'caption='[[5tjx]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5tjx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TJX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TJX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5tjx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TJX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GBT:(8E)-3-AMINO-1-METHYL-15-[(1H-PYRAZOL-1-YL)METHYL]-7,10,11,12,24,25-HEXAHYDRO-6H,18H,23H-19,22-(METHENO)PYRIDO[4,3-J][1,9,13,17,18]BENZODIOXATRIAZACYCLOHENICOSIN-23-ONE'>GBT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.408&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLKB1, KLK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GBT:(8E)-3-AMINO-1-METHYL-15-[(1H-PYRAZOL-1-YL)METHYL]-7,10,11,12,24,25-HEXAHYDRO-6H,18H,23H-19,22-(METHENO)PYRIDO[4,3-J][1,9,13,17,18]BENZODIOXATRIAZACYCLOHENICOSIN-23-ONE'>GBT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasma_kallikrein Plasma kallikrein], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.34 3.4.21.34] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tjx OCA], [https://pdbe.org/5tjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tjx RCSB], [https://www.ebi.ac.uk/pdbsum/5tjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tjx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tjx OCA], [http://pdbe.org/5tjx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tjx RCSB], [http://www.ebi.ac.uk/pdbsum/5tjx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tjx ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[http://omim.org/entry/612423 612423]]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
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[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[https://omim.org/entry/612423 612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
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[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Plasma kallikrein]]
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[[Category: Choy RM]]
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[[Category: Choy, R M]]
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[[Category: Li Z]]
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[[Category: Li, Z]]
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[[Category: Partridge JR]]
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[[Category: Partridge, J R]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor]]
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[[Category: Protease]]
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[[Category: Serine]]
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Current revision

Structure of human plasma kallikrein

PDB ID 5tjx

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OCA

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