6t4v

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==Crystal structure of 2-methylisocitrate lyase (PrpB) from Pseudomonas aeruginosa in apo form.==
==Crystal structure of 2-methylisocitrate lyase (PrpB) from Pseudomonas aeruginosa in apo form.==
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<StructureSection load='6t4v' size='340' side='right'caption='[[6t4v]]' scene=''>
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<StructureSection load='6t4v' size='340' side='right'caption='[[6t4v]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T4V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T4V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6t4v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T4V FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t4v OCA], [http://pdbe.org/6t4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t4v RCSB], [http://www.ebi.ac.uk/pdbsum/6t4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t4v ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.807&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t4v OCA], [https://pdbe.org/6t4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t4v RCSB], [https://www.ebi.ac.uk/pdbsum/6t4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t4v ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9I5E2_PSEAE Q9I5E2_PSEAE] Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.[RuleBase:RU361121] Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.[HAMAP-Rule:MF_01939]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Brear P]]
[[Category: Brear P]]
[[Category: Dolan SK]]
[[Category: Dolan SK]]
[[Category: Welch M]]
[[Category: Welch M]]
[[Category: Wijaya AJ]]
[[Category: Wijaya AJ]]

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Crystal structure of 2-methylisocitrate lyase (PrpB) from Pseudomonas aeruginosa in apo form.

PDB ID 6t4v

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