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| | <StructureSection load='7jrh' size='340' side='right'caption='[[7jrh]], [[Resolution|resolution]] 1.32Å' scene=''> | | <StructureSection load='7jrh' size='340' side='right'caption='[[7jrh]], [[Resolution|resolution]] 1.32Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[7jrh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JRH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JRH FirstGlance]. <br> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JRH FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32Å</td></tr> |
| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jrh OCA], [http://pdbe.org/7jrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jrh RCSB], [http://www.ebi.ac.uk/pdbsum/7jrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jrh ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jrh OCA], [https://pdbe.org/7jrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jrh RCSB], [https://www.ebi.ac.uk/pdbsum/7jrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jrh ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| Line 22: |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Howitz, W J]] | + | [[Category: Howitz WJ]] |
| - | [[Category: Nowick, J S]] | + | [[Category: Nowick JS]] |
| - | [[Category: Wierzbicki, M]] | + | [[Category: Wierzbicki M]] |
| - | [[Category: Cyclic]]
| + | |
| - | [[Category: De novo protein]]
| + | |
| - | [[Category: Framework]]
| + | |
| - | [[Category: Hairpin]]
| + | |
| - | [[Category: Medin]]
| + | |
| - | [[Category: Mof]]
| + | |
| Structural highlights
Publication Abstract from PubMed
Amyloidogenic peptides and proteins are rich sources of supramolecular assemblies. Sequences derived from well-known amyloids, including Abeta, human islet amyloid polypeptide, and tau have been found to assemble as fibrils, nanosheets, ribbons, and nanotubes. The supramolecular assembly of medin, a 50-amino acid peptide that forms fibrillary deposits in aging human vasculature, has not been heavily investigated. In this work, we present an X-ray crystallographic structure of a cyclic beta-sheet peptide derived from the 19-36 region of medin that assembles to form interpenetrating cubes. The edge of each cube is composed of a single peptide, and each vertex is occupied by a divalent metal ion. This structure may be considered a metal-organic framework (MOF) containing a large peptide ligand. This work demonstrates that peptides containing Glu or Asp that are preorganized to adopt beta-hairpin structures can serve as ligands and assemble with metal ions to form MOFs.
Interpenetrating Cubes in the X-ray Crystallographic Structure of a Peptide Derived from Medin19-36.,Howitz WJ, Wierzbicki M, Cabanela RW, Saliba C, Motavalli A, Tran N, Nowick JS J Am Chem Soc. 2020 Sep 3. doi: 10.1021/jacs.0c06143. PMID:32816461[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Howitz WJ, Wierzbicki M, Cabanela RW, Saliba C, Motavalli A, Tran N, Nowick JS. Interpenetrating Cubes in the X-ray Crystallographic Structure of a Peptide Derived from Medin19-36. J Am Chem Soc. 2020 Sep 3. doi: 10.1021/jacs.0c06143. PMID:32816461 doi:http://dx.doi.org/10.1021/jacs.0c06143
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