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1svz
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="1svz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1svz, resolution 1.89Å" /> '''Crystal structure o...) |
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| - | [[Image:1svz.gif|left|200px]]<br /> | ||
| - | <applet load="1svz" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1svz, resolution 1.89Å" /> | ||
| - | '''Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease'''<br /> | ||
| - | == | + | ==Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease== |
| - | The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the | + | <StructureSection load='1svz' size='340' side='right'caption='[[1svz]], [[Resolution|resolution]] 1.89Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1svz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SVZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1svz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1svz OCA], [https://pdbe.org/1svz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1svz RCSB], [https://www.ebi.ac.uk/pdbsum/1svz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1svz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KV2A7_MOUSE KV2A7_MOUSE] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sv/1svz_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1svz ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the activity of both HIV-1 and HIV-2 proteases with inhibition constants in the low nanomolar range. The antibody cross-reacts with peptides derived from the N-terminal region of both proteases. The crystal structure of the recombinant single-chain Fv fragment of 1696 complexed with an N-terminal peptide from the HIV-2 protease has been determined at 1.88A resolution. Interactions of the peptide with scFv1696 are compared with the previously reported structure of scFv1696 in complex with the corresponding peptide from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV proteases is discussed. | ||
| - | + | Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide.,Rezacova P, Brynda J, Lescar J, Fabry M, Horejsi M, Sieglova I, Sedlacek J, Bentley GA J Struct Biol. 2005 Mar;149(3):332-7. PMID:15721587<ref>PMID:15721587</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1svz" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Antibody 3D structures|Antibody 3D structures]] | ||
| + | *[[3D structures of non-human antibody|3D structures of non-human antibody]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Bentley GA]] | ||
| + | [[Category: Brynda J]] | ||
| + | [[Category: Fabry M]] | ||
| + | [[Category: Horejsi M]] | ||
| + | [[Category: Lescar J]] | ||
| + | [[Category: Rezacova P]] | ||
| + | [[Category: Sedlacek J]] | ||
Current revision
Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease
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Categories: Large Structures | Mus musculus | Bentley GA | Brynda J | Fabry M | Horejsi M | Lescar J | Rezacova P | Sedlacek J
