7d4a

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(New page: ==The Crystal Structure of human JMJD2A Tudor domain from Biortus== <StructureSection load='7d4a' size='340' side='right'caption='7d4a' scene=''> == Structural highlights == <table><t...)
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==The Crystal Structure of human JMJD2A Tudor domain from Biortus==
==The Crystal Structure of human JMJD2A Tudor domain from Biortus==
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<StructureSection load='7d4a' size='340' side='right'caption='[[7d4a]]' scene=''>
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<StructureSection load='7d4a' size='340' side='right'caption='[[7d4a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D4A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7D4A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7d4a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D4A FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7d4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d4a OCA], [http://pdbe.org/7d4a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7d4a RCSB], [http://www.ebi.ac.uk/pdbsum/7d4a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7d4a ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.201&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d4a OCA], [https://pdbe.org/7d4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d4a RCSB], [https://www.ebi.ac.uk/pdbsum/7d4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d4a ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>
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==See Also==
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*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bao X]]
[[Category: Bao X]]

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The Crystal Structure of human JMJD2A Tudor domain from Biortus

PDB ID 7d4a

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