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1v04

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Current revision (13:23, 9 May 2024) (edit) (undo)
 
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<StructureSection load='1v04' size='340' side='right'caption='[[1v04]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1v04' size='340' side='right'caption='[[1v04]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1V04 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1v04]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus], [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] and [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V04 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [http://pdbe.org/1v04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [http://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v04 ProSAT], [http://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v04 OCA], [https://pdbe.org/1v04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v04 RCSB], [https://www.ebi.ac.uk/pdbsum/1v04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v04 ProSAT], [https://www.topsan.org/Proteins/ISPC/1v04 TOPSAN]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PON1_RABIT PON1_RABIT] Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.<ref>PMID:11266077</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Joel Sussman's Favorites|Joel Sussman's Favorites]]
 
*[[Serum Paraoxonase|Serum Paraoxonase]]
*[[Serum Paraoxonase|Serum Paraoxonase]]
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*[[User:Boris Brumshtein|User:Boris Brumshtein]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aharoni, A]]
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[[Category: Mus musculus]]
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[[Category: Brumshtein, B]]
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[[Category: Oryctolagus cuniculus]]
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[[Category: Dvir, H]]
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[[Category: Rattus rattus]]
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[[Category: Gaidukov, L]]
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[[Category: Aharoni A]]
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[[Category: Harel, M]]
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[[Category: Brumshtein B]]
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[[Category: Khersonsky, O]]
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[[Category: Dvir H]]
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[[Category: McCarthy, A]]
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[[Category: Gaidukov L]]
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[[Category: Meged, R]]
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[[Category: Harel M]]
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[[Category: Ravelli, R B.G]]
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[[Category: Khersonsky O]]
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[[Category: Silman, I]]
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[[Category: McCarthy A]]
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[[Category: Sussman, J L]]
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[[Category: Meged R]]
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[[Category: Tawfik, D S]]
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[[Category: Ravelli RBG]]
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[[Category: Toker, L]]
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[[Category: Silman I]]
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[[Category: Yagur, S]]
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[[Category: Sussman JL]]
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[[Category: Antioxidant]]
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[[Category: Tawfik DS]]
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[[Category: Directed evolution]]
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[[Category: Toker L]]
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[[Category: Hydrolase]]
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[[Category: Yagur S]]
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[[Category: ISPC, Israel Structural Proteomics Center]]
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[[Category: Paraoxonase]]
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[[Category: Structural genomic]]
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Current revision

serum paraoxonase by directed evolution

PDB ID 1v04

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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