Cystathionine gamma synthase
From Proteopedia
(Difference between revisions)
| (8 intermediate revisions not shown.) | |||
| Line 11: | Line 11: | ||
== Structural highlights == | == Structural highlights == | ||
| - | The 3D structure of tobacco CGS complex with an inhibitor shows the interaction of the inhibitor in the substrate binding pocket of CGS dimer. The carboxylate moiety of the inhibitor makes hydrogen bond to Arg and its phosphonate group binds to phosphate recognition group formed by residues from both monomers<ref>PMID:11518531</ref>. | + | The 3D structure of tobacco CGS complex with an inhibitor shows <scene name='86/863207/Cv/5'>the interaction of the inhibitor in the substrate binding pocket of CGS dimer</scene>. The carboxylate moiety of the inhibitor makes hydrogen bond to <scene name='86/863207/Cv/13'>Arg</scene> and its <scene name='86/863207/Cv/7'>phosphonate group binds to phosphate recognition group formed by residues from both monomers</scene><ref>PMID:11518531</ref>. |
</StructureSection> | </StructureSection> | ||
| Line 24: | Line 24: | ||
[[4l0o]] - CGS + PLP - ''Helicobacter pylori''<br /> | [[4l0o]] - CGS + PLP - ''Helicobacter pylori''<br /> | ||
[[6s0c]] - CGS + PLP - ''Citrobacter freundii''<br /> | [[6s0c]] - CGS + PLP - ''Citrobacter freundii''<br /> | ||
| + | [[9axj]] - CGS + Pyridine derivative – ''Thermobifida fusca'' <br /> | ||
[[3qi6]], [[3qhx]] - CGS MetB - ''Mycobacterium ulcerans''<br /> | [[3qi6]], [[3qhx]] - CGS MetB - ''Mycobacterium ulcerans''<br /> | ||
[[5x5h]] - CGS MetB - ''Corynebacterium glutamicum''<br /> | [[5x5h]] - CGS MetB - ''Corynebacterium glutamicum''<br /> | ||
| + | [[6ld7]] - XoCGS (mutant`) + PLP derivative - ''Xanthomonas oryzae''<br /> | ||
| + | [[6ld9]] - XoCGS (mutant`) + cystathionine <br /> | ||
| + | [[6ld8]] - XoCGS (mutant`) + cysteine + aminoacrylate<br /> | ||
| + | [[6lgo]] - XoCGS (mutant`) + homolanthionine <br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
3D structures of cystathionine gamma synthase
Updated on 20-February-2025
1i41 - tCGS + inhibitor - tobacco
1qgn - tCGS + PLP
1i43, 1i48 - tCGS + PLP + inhibitor
1cs1 - CGS + PLP derivative - Eschericia coli
4l0o - CGS + PLP - Helicobacter pylori
6s0c - CGS + PLP - Citrobacter freundii
9axj - CGS + Pyridine derivative – Thermobifida fusca
3qi6, 3qhx - CGS MetB - Mycobacterium ulcerans
5x5h - CGS MetB - Corynebacterium glutamicum
6ld7 - XoCGS (mutant`) + PLP derivative - Xanthomonas oryzae
6ld9 - XoCGS (mutant`) + cystathionine
6ld8 - XoCGS (mutant`) + cysteine + aminoacrylate
6lgo - XoCGS (mutant`) + homolanthionine
References
- ↑ Flavin M, Slaughter C. Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine. Biochim Biophys Acta. 1967 Mar 15;132(2):400-5. doi:, 10.1016/0005-2744(67)90158-1. PMID:5340123 doi:http://dx.doi.org/10.1016/0005-2744(67)90158-1
- ↑ Fu J, Wu J, Jiang J, Wang Z, Ma Z. Cystathionine gamma-synthase is essential for methionine biosynthesis in Fusarium graminearum. Fungal Biol. 2013 Jan;117(1):13-21. doi: 10.1016/j.funbio.2012.11.001. Epub 2012 , Dec 1. PMID:23332829 doi:http://dx.doi.org/10.1016/j.funbio.2012.11.001
- ↑ Steegborn C, Laber B, Messerschmidt A, Huber R, Clausen T. Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor. J Mol Biol. 2001 Aug 24;311(4):789-801. PMID:11518531 doi:10.1006/jmbi.2001.4880
