Mevalonate kinase
From Proteopedia
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| - | <StructureSection load='2hfu' size='340' side='right' caption=' | + | <StructureSection load='2hfu' size='340' side='right' caption='Mevalonate kinase complex with mevalonate (PDB code [[2hfu]]).' scene='86/864102/Cv/1'> |
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
| - | '''Mevalonate kinase''' (MK) is the first enzyme in the mevalonate pathway which synthesizes sterol isoprenoids like cholesterol and non-sterol isoprenoids like ubiquinone<ref>PMID:17467679</ref>. | + | '''Mevalonate kinase''' (MK) is the first enzyme in the mevalonate pathway which synthesizes sterol isoprenoids like cholesterol and non-sterol isoprenoids like ubiquinone<ref>PMID:17467679</ref>. MK catalyzes the conversion of mevalonate to 5-phosphomevalonate. |
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| + | See also [[Mevalonate pathway]] | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| + | The 3D structure of MK complex with mevalonate shows the enzyme composed of <scene name='86/864102/Cv/2'>2 domains</scene>: The N-terminal and the C-terminal. The mevalonate binds in a <scene name='86/864102/Cv/7'>deep cleft</scene> between the 2 domains forming <scene name='86/864102/Cv/6'>H-bonds and hydrophobic interactions</scene><ref>PMID:17397541</ref>. Water molecules are shown as red spheres. | ||
==3D structures of mevalonate kinase== | ==3D structures of mevalonate kinase== | ||
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| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[2r3v]] - hMK - human<br /> | [[2r3v]] - hMK - human<br /> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Buhaescu I, Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications. Clin Biochem. 2007 Jun;40(9-10):575-84. doi: 10.1016/j.clinbiochem.2007.03.016., Epub 2007 Mar 31. PMID:17467679 doi:http://dx.doi.org/10.1016/j.clinbiochem.2007.03.016
- ↑ Levy M, Arion A, Berrebi D, Cuisset L, Jeanne-Pasquier C, Bader-Meunier B, Jung C. Severe early-onset colitis revealing mevalonate kinase deficiency. Pediatrics. 2013 Sep;132(3):e779-83. doi: 10.1542/peds.2012-3344. Epub 2013 Aug, 26. PMID:23979089 doi:http://dx.doi.org/10.1542/peds.2012-3344
- ↑ Sgraja T, Smith TK, Hunter WN. Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. BMC Struct Biol. 2007 Mar 30;7:20. PMID:17397541 doi:10.1186/1472-6807-7-20
