7jye
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Liver Receptor Homolog-1 in Complex with 9ChoP and a Fragment of Tif2== | |
| + | <StructureSection load='7jye' size='340' side='right'caption='[[7jye]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7jye]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JYE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.551Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VQY:9-[(3~{a}~{R},6~{R},6~{a}~{R})-6-oxidanyl-3-phenyl-3~{a}-(1-phenylethenyl)-4,5,6,6~{a}-tetrahydro-1~{H}-pentalen-2-yl]nonyl+2-(trimethyl-$l^{4}-azanyl)ethyl+hydrogen+phosphate'>VQY</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jye OCA], [https://pdbe.org/7jye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jye RCSB], [https://www.ebi.ac.uk/pdbsum/7jye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jye ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. | ||
| - | + | ==See Also== | |
| - | + | *[[Liver receptor homolog-1|Liver receptor homolog-1]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: D'Agostino EH]] | ||
| + | [[Category: Mays SG]] | ||
| + | [[Category: Ortlund EA]] | ||
Current revision
Human Liver Receptor Homolog-1 in Complex with 9ChoP and a Fragment of Tif2
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