7k3s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution NMR Structure of the Coiled-coil BRCA1-PALB2 Heterodimer== | |
| - | + | <StructureSection load='7k3s' size='340' side='right'caption='[[7k3s]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7k3s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K3S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k3s OCA], [https://pdbe.org/7k3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k3s RCSB], [https://www.ebi.ac.uk/pdbsum/7k3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k3s ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRCA1_MOUSE BRCA1_MOUSE] E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.[UniProtKB:P38398] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Bunting SF]] | ||
| + | [[Category: Daigham NS]] | ||
| + | [[Category: Liu G]] | ||
| + | [[Category: Montelione GT]] | ||
Current revision
Solution NMR Structure of the Coiled-coil BRCA1-PALB2 Heterodimer
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