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3eo2
From Proteopedia
(Difference between revisions)
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<StructureSection load='3eo2' size='340' side='right'caption='[[3eo2]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='3eo2' size='340' side='right'caption='[[3eo2]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3eo2]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3eo2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EO2 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eo2 OCA], [https://pdbe.org/3eo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eo2 RCSB], [https://www.ebi.ac.uk/pdbsum/3eo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eo2 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ARHG8_HUMAN ARHG8_HUMAN] Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.<ref>PMID:21373644</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Bochkarev A]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: MacKenzie | + | [[Category: MacKenzie F]] |
| - | [[Category: Nedyalkova | + | [[Category: Nedyalkova L]] |
| - | [[Category: Park | + | [[Category: Park H]] |
| - | + | [[Category: Tempel W]] | |
| - | [[Category: Tempel | + | [[Category: Tong Y]] |
| - | [[Category: Tong | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | |
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Current revision
Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bochkarev A | Bountra C | Edwards AM | MacKenzie F | Nedyalkova L | Park H | Tempel W | Tong Y | Weigelt J
