Serine/threonine protein kinase 3D structures

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**[[1nvq]], [[1nvr]] – hChk1 kinase domain + peptide + saurosporine
**[[1nvq]], [[1nvr]] – hChk1 kinase domain + peptide + saurosporine
-
**[[1nvs]], [[1zys]] - hChk1 kinase domain + peptide + inhibitor
+
**[[1nvs]], [[1zys]], [[7ako]] - hChk1 kinase domain + peptide + inhibitor
-
**[[2cgu]], [[2cgv]], [[2cgw]], [[2cgx]], [[2c3j]], [[2c3k]], [[2c3l]], [[2br1]], [[2brb]], [[2brg]], [[2brh]], [[2brm]], [[2brn]], [[2bro]], [[2ayp]], [[2gdo]], [[2ghg]], [[2hog]], [[2ywp]], [[2hxl]], [[2hxq]], [[2hy0]], [[2r0u]], [[2e9n]], [[2e9o]], [[2e9p]], [[2e9u]], [[2e9v]], [[2qhm]], [[2qhn]], [[3f9n]], [[2wmq]], [[2wmr]], [[2wms]], [[2wmt]], [[2wmu]], [[2wmv]], [[2wmx]], [[3jvr]], [[3jvs]], [[2xey]], [[2xf0]], [[2xez]], [[2x8d]], [[2x8e]], [[2x8i]], [[3ot3]], [[3ot8]], [[3pa3]], [[3pa4]], [[3pa5]], [[3nlb]], [[2wmw]], [[2ydi]], [[2ydj]], [[2ydk]], [[2yer]], [[2yex]], [[2ym3]], [[2ym4]], [[2ym5]], [[2ym6]], [[2ym7]], [[2ym8]], [[3tkh]], [[3tki]], [[3u9n]], [[4fsm]], [[4fsn]], [[4fsq]], [[4fsr]], [[4fst]], [[4fsu]], [[4fsw]], [[4fsy]], [[4fsz]], [[4ft0]], [[4ft3]], [[4ft5]], [[4ft7]], [[4ft9]], [[4fta]], [[4ftc]], [[4fti]], [[4ftj]], [[4ftk]], [[4ftl]], [[4ftm]], [[4ftn]], [[4fto]], [[4ftq]], [[4ftr]], [[4ftt]], [[4ftu]], [[4gh2]], [[4hyh]], [[4hyi]], [[4jik]], [[4rvm]], [[4rvl]], [[4rvk]], [[4qyh]], [[4qyg]], [[4qyf]], [[4qye]], [[5dls]], [[5f4n]], [[6fc8]], [[5fcf]], [[5fck]], [[6fck]], [[6fcf]] - hChk1 kinase domain + inhibitor<br />
+
**[[7akm]] - hChk1 kinase domain + ATP<br />
-
**[[5oot]], [[5op2]], [[5op4]], [[5op5]], [[5op7]], [[5opb]], [[5opr]], [[5ops]], [[5opu]], [[5opv]], [[5oq5]], [[5oq6]], [[5oq7]], [[5oq8]] - hChk1 kinase domain (mutant) + inhibitor<br />
+
**[[2cgu]], [[2cgv]], [[2cgw]], [[2cgx]], [[2c3j]], [[2c3k]], [[2c3l]], [[2br1]], [[2brb]], [[2brg]], [[2brh]], [[2brm]], [[2brn]], [[2bro]], [[2ayp]], [[2gdo]], [[2ghg]], [[2hog]], [[2ywp]], [[2hxl]], [[2hxq]], [[2hy0]], [[2r0u]], [[2e9n]], [[2e9o]], [[2e9p]], [[2e9u]], [[2e9v]], [[2qhm]], [[2qhn]], [[3f9n]], [[2wmq]], [[2wmr]], [[2wms]], [[2wmt]], [[2wmu]], [[2wmv]], [[2wmx]], [[3jvr]], [[3jvs]], [[2xey]], [[2xf0]], [[2xez]], [[2x8d]], [[2x8e]], [[2x8i]], [[3ot3]], [[3ot8]], [[3pa3]], [[3pa4]], [[3pa5]], [[3nlb]], [[2wmw]], [[2ydi]], [[2ydj]], [[2ydk]], [[2yer]], [[2yex]], [[2ym3]], [[2ym4]], [[2ym5]], [[2ym6]], [[2ym7]], [[2ym8]], [[3tkh]], [[3tki]], [[3u9n]], [[4fsm]], [[4fsn]], [[4fsq]], [[4fsr]], [[4fst]], [[4fsu]], [[4fsw]], [[4fsy]], [[4fsz]], [[4ft0]], [[4ft3]], [[4ft5]], [[4ft7]], [[4ft9]], [[4fta]], [[4ftc]], [[4fti]], [[4ftj]], [[4ftk]], [[4ftl]], [[4ftm]], [[4ftn]], [[4fto]], [[4ftq]], [[4ftr]], [[4ftt]], [[4ftu]], [[4gh2]], [[4hyh]], [[4hyi]], [[4jik]], [[4rvm]], [[4rvl]], [[4rvk]], [[4qyh]], [[4qyg]], [[4qyf]], [[4qye]], [[5dls]], [[5f4n]], [[6fc8]], [[5fcf]], [[5fck]], [[6fck]], [[6fcf]], [[7bko]], [[8e80]]. ]]8o81]] - hChk1 kinase domain + inhibitor<br />
 +
**[[5oot]], [[5op2]], [[5op4]], [[5op5]], [[5op7]], [[5opb]], [[5opr]], [[5ops]], [[5opu]], [[5opv]], [[5oq5]], [[5oq6]], [[5oq7]], [[5oq8]], [[7bjd]], [[7bjh]], [[7bjj]], [[7bjm]], [[7bjo]], [[7bjr]], [[7bjx]], [[7bk1]], [[7bk2]], [[7bk3]], [[7mck]], [[7suf]], [[7sug]], [[7suh]], [[7sui]], [[7suj]], [[8siv]], [[8siw]], [[8six]] - hChk1 kinase domain (mutant) + inhibitor<br />
**[[5oop]] - hChk1 kinase domain (mutant) + AMPPNP<br />
**[[5oop]] - hChk1 kinase domain (mutant) + AMPPNP<br />
**[[5oor]] - hChk1 kinase domain (mutant) + staurosporine<br />
**[[5oor]] - hChk1 kinase domain (mutant) + staurosporine<br />
 +
**[[7bkn]] - hChk1 kinase domain + adenine<br />
 +
**[[7bje]] - hChk1 kinase domain (mutant) + adenine<br />
**[[2jqi]] – yChk1 – yeast<br />
**[[2jqi]] – yChk1 – yeast<br />
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**[[4lgd]] – hChk3 kinase domain + RASSF5 SARAH domain<br />
**[[4lgd]] – hChk3 kinase domain + RASSF5 SARAH domain<br />
**[[6ao5]] – hChk3 kinase+SARAH domains (mutant) + SAV1 SARAH domain<br />
**[[6ao5]] – hChk3 kinase+SARAH domains (mutant) + SAV1 SARAH domain<br />
-
**[[5dh3]] – hChk3 kinase domain + inhibitor<br />
+
**[[5dh3]], [[8a66]] – hChk3 kinase domain + inhibitor<br />
-
*'''Chk4 (Mst1)'''
+
*'''Chk4 (Mst1)''' ); Domains – kinase 1-311; SARAH 432-480
-
**[[2jo8]] – hChk4 C terminal domain - NMR<br />
 
**[[3com]] – hChk4 kinase domain<br />
**[[3com]] – hChk4 kinase domain<br />
 +
**[[6yat]], [[8a5j]] – hChk4 kinase domain + inhibitor<br />
**[[4nr2]] – hChk4 SARAH domain<br />
**[[4nr2]] – hChk4 SARAH domain<br />
 +
**[[2jo8]] – hChk4 SARAH domain - NMR<br />
**[[4oh8]] – hChk4 SARAH domain + Ras association domain-containing protein<br />
**[[4oh8]] – hChk4 SARAH domain + Ras association domain-containing protein<br />
Line 63: Line 67:
**[[6cpf]] – hChk6 kinase domain + AMPPCP<br />
**[[6cpf]] – hChk6 kinase domain + AMPPCP<br />
**[[5g15]] – hChk6 kinase domain + AMPPNP + monobody<br />
**[[5g15]] – hChk6 kinase domain + AMPPNP + monobody<br />
-
**[[6cpg]] – hChk6 kinase domain + inhibitor + monobody<br />
+
**[[6cpg]], [[8ssp]] – hChk6 kinase domain + inhibitor + monobody<br />
-
**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]], [[4byi]], [[4byj]], [[4jai]], [[4jaj]], [[3w10]], [[3w16]], [[3w18]], [[3w2c]], [[4uzh]], [[4uzd]], [[4uyn]], [[4zs0]], [[4ztq]], [[4ztr]], [[4zts]], [[5aad]], [[5aae]], [[5aag]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5obr]], [[5one]], [[6gra]], [[6c2t]], [[6c2r]], [[5zan]] – hChk6 kinase domain + inhibitor<br />
+
**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]], [[4byi]], [[4byj]], [[4jai]], [[4jaj]], [[3w10]], [[3w16]], [[3w18]], [[3w2c]], [[4uzh]], [[4uzd]], [[4uyn]], [[4zs0]], [[4ztq]], [[4ztr]], [[4zts]], [[5aad]], [[5aae]], [[5aag]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5obr]], [[5one]], [[6gra]], [[6c2t]], [[6c2r]], [[5zan]], [[6z4y]], [[7ayh]], [[7ayi]], [[7fic]], [[7o2v]], [[8jmx]] – hChk6 kinase domain + inhibitor<br />
**[[2bmc]], [[2c6e]], [[3coh]], [[3h0y]], [[3h0z]], [[3h10]], [[3fdn]], [[2wtw]], [[3lau]], [[3nrm]], [[2xne]], [[2xng]], [[2xru]], [[3k5u]], [[3m11]], [[3p9j]], [[3r21]], [[3r22]], [[3qbn]], [[3unz]], [[3uo4]], [[3uo5]], [[3uo6]], [[3uod]], [[3uoh]], [[3uoj]], [[3uok]], [[3uol]], [[3up2]], [[3up7]], [[4dhf]], [[4dea]], [[4deb]], [[4ded]], [[4dee]], [[5aad]], [[5aae]], [[5aaf]], [[5aag]], [[4jbo]], [[4jbp]], [[4jbq]], [[4prj]], [[5dpv]], [[6hjk]], [[6hjj]] – hChk6 kinase domain (mutant) + inhibitor<br />
**[[2bmc]], [[2c6e]], [[3coh]], [[3h0y]], [[3h0z]], [[3h10]], [[3fdn]], [[2wtw]], [[3lau]], [[3nrm]], [[2xne]], [[2xng]], [[2xru]], [[3k5u]], [[3m11]], [[3p9j]], [[3r21]], [[3r22]], [[3qbn]], [[3unz]], [[3uo4]], [[3uo5]], [[3uo6]], [[3uod]], [[3uoh]], [[3uoj]], [[3uok]], [[3uol]], [[3up2]], [[3up7]], [[4dhf]], [[4dea]], [[4deb]], [[4ded]], [[4dee]], [[5aad]], [[5aae]], [[5aaf]], [[5aag]], [[4jbo]], [[4jbp]], [[4jbq]], [[4prj]], [[5dpv]], [[6hjk]], [[6hjj]] – hChk6 kinase domain (mutant) + inhibitor<br />
**[[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor<br />
**[[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor<br />
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**[[5dn3]], [[5dos]], [[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor <br />
**[[5dn3]], [[5dos]], [[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor <br />
**[[6c83]] – hChk6 kinase domain + AMPPCP + nanobody<br />
**[[6c83]] – hChk6 kinase domain + AMPPCP + nanobody<br />
 +
**[[8sso]] – hChk6 kinase domain + drug + monobody<br />
**[[5dr2]] – hChk6 kinase domain (mutant) + ATP + inhibitor <br />
**[[5dr2]] – hChk6 kinase domain (mutant) + ATP + inhibitor <br />
-
**[[5g1x]] – hChk6 kinase domain (mutant) + N-Myc <br />
+
**[[5g1x]], [[7ztl]] – hChk6 kinase domain (mutant) + N-Myc <br />
 +
**[[8guw]] – hChk6 kinase domain/activator peptide <br />
**[[5l8j]], [[5l8k]], [[5l8l]] – hChk6 kinase domain (mutant) + new antigen receptor variable domain <br />
**[[5l8j]], [[5l8k]], [[5l8l]] – hChk6 kinase domain (mutant) + new antigen receptor variable domain <br />
**[[5lxm]] – hChk6 kinase domain (mutant) + Targeting protein for XKLP2 <br />
**[[5lxm]] – hChk6 kinase domain (mutant) + Targeting protein for XKLP2 <br />
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**[[6r49]] – hChk6 kinase domain (mutant) + PThr + CoA<br />
**[[6r49]] – hChk6 kinase domain (mutant) + PThr + CoA<br />
-
*'''Chk10 (lymphocyte-oriented kinase)'''
+
*'''Chk10 (lymphocyte-oriented kinase)''' or LOK or STK10
-
**[[2j7t]], [[4aot]], [[4equ]], [[5ajq]], [[5owq]], [[5owr]], [[6eim]], [[6gtt]], [[6i2y]], [[6hxf]] – hChk10 kinase domain + inhibitor<br />
+
**[[7qgp]] – hChk10 <br />
 +
**[[2j7t]], [[4aot]], [[4equ]], [[4usd]], [[4use]], [[5ajq]], [[5owq]], [[5owr]], [[6eim]], [[6gtt]], [[6i2y]], [[6hxf]] – hChk10 kinase domain + inhibitor<br />
 +
**[[4bc6]], [[6i2y]] – hChk10 + drug <br />
*'''Chk11'''
*'''Chk11'''
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*'''Chk13 (Polo-like kinase Plk)'''
*'''Chk13 (Polo-like kinase Plk)'''
-
*Plk1 Polo-box domain (Pbd)''
+
*Plk1 Polo-box domain (Pbd) 371-594''
**[[1q4o]], [[2ogq]], [[3hih]], [[3p2w]], [[4h5x]], [[6n46]] – hPlk1 Pbd<br />
**[[1q4o]], [[2ogq]], [[3hih]], [[3p2w]], [[4h5x]], [[6n46]] – hPlk1 Pbd<br />
 +
**[[8joq]], [[8joy]] – hPlk1 Pbd + hpv peptide<br />
*Plk1 Pbd complex with polypeptide
*Plk1 Pbd complex with polypeptide
-
**[[1umw]], [[2ojx]], [[3bzi]], [[3c5l]], [[3rq7]], [[4dfw]], [[4whl]], [[4whk]], [[4whh]], [[4rcp]], [[4o6w]], [[4o56]], [[5dms]], [[5dmv]], [[5dnj]] – hPlk1 + peptide<br />
+
**[[1umw]], [[2ojx]], [[3bzi]], [[3c5l]], [[3rq7]], [[4dfw]], [[4whl]], [[4whk]], [[4whh]], [[4rcp]], [[4o6w]], [[4o56]], [[5dms]], [[5dmv]], [[5dnj]], [[7mso]], [[7mx1]] – hPlk1 + peptide<br />
**[[3hik]], [[3fvh]], [[3p2z]], [[3p34]], [[3p35]], [[3p36]], [[3p37]], [[3q1i]], [[4e67]], [[4e9c]], [[4e9d]], [[4hab]], [[4hy2]], [[4o9w]], [[4x9r]], [[4x9v]], [[4x9w]], [[5j19]], [[6gy2]] – hPlk1 + phosphopeptide<br />
**[[3hik]], [[3fvh]], [[3p2z]], [[3p34]], [[3p35]], [[3p36]], [[3p37]], [[3q1i]], [[4e67]], [[4e9c]], [[4e9d]], [[4hab]], [[4hy2]], [[4o9w]], [[4x9r]], [[4x9v]], [[4x9w]], [[5j19]], [[6gy2]] – hPlk1 + phosphopeptide<br />
**[[1q4k]] – hPlk1 (mutant) + phosphopeptide<br />
**[[1q4k]] – hPlk1 (mutant) + phosphopeptide<br />
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**[[6ax4]] – hChk Plk1 + histidine cyclized macrocycle <br />
**[[6ax4]] – hChk Plk1 + histidine cyclized macrocycle <br />
**[[5x3s]] – mPlk1 + phosphopeptide<br />
**[[5x3s]] – mPlk1 + phosphopeptide<br />
 +
**[[8joq]], [[8joy]] – hPlk1 Pbd + hpv peptide<br />
*Plk1 Pbd complex with small molecule inhibitor
*Plk1 Pbd complex with small molecule inhibitor
-
**[[4h71]], [[4hco]], [[5ta6]], [[5ta8]] – hPlk1 + inhibitor<br />
+
**[[4h71]], [[4hco]], [[5ta6]], [[5ta8]], [[8bjt]], [[8crc]] – hPlk1 + inhibitor<br />
**[[2rku]] – hPlk1 (mutant) + inhibitor<br />
**[[2rku]] – hPlk1 (mutant) + inhibitor<br />
**[[3db6]], [[3db8]], [[3dbc]], [[3dbd]], [[3dbe]], [[3dbf]] – zfPlk1 (mutant) + inhibitor – zebra fish<br />
**[[3db6]], [[3db8]], [[3dbc]], [[3dbd]], [[3dbe]], [[3dbf]] – zfPlk1 (mutant) + inhibitor – zebra fish<br />
-
*Plk1 catalytic domain
+
*Plk1 catalytic domain 36-345
**[[2owb]] – hPlk1 catalytic domain (mutant)<br />
**[[2owb]] – hPlk1 catalytic domain (mutant)<br />
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**[[4b6l]], [[4i6b]] – hChk Plk3 kinase domain + inhibitor<br />
**[[4b6l]], [[4i6b]] – hChk Plk3 kinase domain + inhibitor<br />
-
*'''Plk4'''
+
*'''Plk4'''; Domains – kinase 2-275; Pbd 580-808; Pb3 884-970
**[[3cok]] – hChk Plk4 kinase domain<br />
**[[3cok]] – hChk Plk4 kinase domain<br />
**[[4n9j]] – hChk Plk4 Pbd domain<br />
**[[4n9j]] – hChk Plk4 Pbd domain<br />
**[[4n7z]], [[4n7v]] – hChk Plk4 Pbd domain + centrosomal protein <br />
**[[4n7z]], [[4n7v]] – hChk Plk4 Pbd domain + centrosomal protein <br />
 +
**[[6w38]], [[6w3i]] – hChk Plk4 Pbd domain + Fam46C<br />
 +
**[[6w3j]] – hChk Plk4 Pbd domain + Fam46C + CEP92 peptide<br />
**[[4jxf]], [[4yur]] – hChk Plk4 kinase domain + inhibitor<br />
**[[4jxf]], [[4yur]] – hChk Plk4 kinase domain + inhibitor<br />
**[[5lhy]] – hChk Plk4 Pb3 domain<br />
**[[5lhy]] – hChk Plk4 Pb3 domain<br />
**[[4yyp]], [[5lhz]] – hChk Plk4 Pb3 domain + Scl-interrupting locus protein <br />
**[[4yyp]], [[5lhz]] – hChk Plk4 Pb3 domain + Scl-interrupting locus protein <br />
-
**[[4nk7]], [[4g7n]], [[5lhx]] – DmChk Plk4 Pbd domain – ''Drosophila melanogaster''<br />
+
**[[4nk7]], [[4g7n]], [[5lhx]], [[7rl3]] – DmChk Plk4 Pbd domain – ''Drosophila melanogaster''<br />
*'''Chk16'''
*'''Chk16'''
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**[[2buj]] – hChk16 (mutant) + staurosporin <br />
**[[2buj]] – hChk16 (mutant) + staurosporin <br />
-
*'''Chk17'''
+
*'''Chk17B''' or DRAK2 or STK17B
**[[3lm0]] – hChk17B <br />
**[[3lm0]] – hChk17B <br />
-
**[[6qf4]] – hChk17B + ADP<br />
+
**[[6qf4]], [[7q7c]], [[7q7d]] – hChk17B + ADP<br />
 +
**[[7q7e]] – hChk17B + ATP<br />
**[[3lm5]] – hChk17B + quercetin<br />
**[[3lm5]] – hChk17B + quercetin<br />
 +
**[[6y6f]], [[6y6h]], [[6zjf]] – hChk17B + pyrimidine derivative<br />
 +
**[[7akg]] – hChk17B + drug<br />
-
*'''Chk24 (Mst3)'''
+
*'''Chk19''' or STK19
 +
 
 +
**[[7xrb]] – hChk19 <br />
 +
 
 +
*'''Chk24 (Mst3)''' or STK24
**[[3a7f]], [[3a7g]], [[3a7h]], [[3a7i]], [[3a7j]], [[3ckw]] – hChk24 kinase domain <br />
**[[3a7f]], [[3a7g]], [[3a7h]], [[3a7i]], [[3a7j]], [[3ckw]] – hChk24 kinase domain <br />
-
**[[4w8e]], [[4w8d]], [[4u8z]], [[4qmm]], [[4qmn]], [[4qmo]], [[4qmp]], [[4qmq]], [[4qms]], [[4qmt]], [[4qmu]], [[4qmv]], [[4qmw]], [[4qmx]], [[4qmy]], [[4qmz]], [[4qna]], [[4qo9]], [[4u8z]] – hChk Mst3 + inhibitor <br />
+
**[[4w8e]], [[4w8d]], [[4u8z]], [[4qmm]], [[4qmn]], [[4qmo]], [[4qmp]], [[4qmq]], [[4qms]], [[4qmt]], [[4qmu]], [[4qmv]], [[4qmw]], [[4qmx]], [[4qmy]], [[4qmz]], [[4qna]], [[4qo9]], [[4u8z]], [[7b30]], [[7b31]], [[7b32]], [[7b33]], [[7b34]], [[7b35]], [[8bzi]], [[8bzj]], [[8qlr]], [[8qls]], [[8qlt]] – hChk Mst3 + inhibitor <br />
 +
**[[8qlq]] – hChk Mst3 + macrocyclic inhibitor <br /> or STK2
**[[3ckx]] – hChk24 kinase domain + staurosporin <br />
**[[3ckx]] – hChk24 kinase domain + staurosporin <br />
**[[3zhp]] – hChk24 kinase domain + calcium-binding protein <br />
**[[3zhp]] – hChk24 kinase domain + calcium-binding protein <br />
Line 175: Line 195:
**[[4qml]] – hChk Mst3 kinase domain + AMPPNP <br />
**[[4qml]] – hChk Mst3 kinase domain + AMPPNP <br />
-
*'''Chk25'''
+
*'''Chk25 or STK25'''
**[[2xik]] – hChk25 kinase domain<br />
**[[2xik]] – hChk25 kinase domain<br />
 +
**[[7z4v]] – hChk25 kinase domain + inhibitor<br />
**[[3w8h]] – hChk25 regulatory domain + programmed cell death protein 10<br />
**[[3w8h]] – hChk25 regulatory domain + programmed cell death protein 10<br />
**[[4nzw]] – hChk25 kinase domain (mutant) + calcium-binding protein <br />
**[[4nzw]] – hChk25 kinase domain (mutant) + calcium-binding protein <br />
Line 183: Line 204:
*'''Chk26 (Mst4)'''
*'''Chk26 (Mst4)'''
-
**[[3ggf]] – hChk Mst4 + inhibitor <br />
+
**[[3ggf]], [[7b36]] – hChk Mst4 + inhibitor <br />
**[[4geh]], [[3w8i]] - hChk Mst4 dimerization domain + programmed cell death protein 10<br />
**[[4geh]], [[3w8i]] - hChk Mst4 dimerization domain + programmed cell death protein 10<br />
**[[4fza]], [[4fzd]], [[4fzf]] – hChk Mst4 (mutant) + calcium-binding protein <br />
**[[4fza]], [[4fzd]], [[4fzf]] – hChk Mst4 (mutant) + calcium-binding protein <br />
Line 197: Line 218:
*'''Chk39''' or SPAK
*'''Chk39''' or SPAK
 +
**[[7o86]] – hChk39 C-terminal<br />
**[[5d9h]] – mChk39 residues 63-403 + ATP<br />
**[[5d9h]] – mChk39 residues 63-403 + ATP<br />
**[[5dbx]] – mChk39 residues 63-403 (mutant) + AMPPNP<br />
**[[5dbx]] – mChk39 residues 63-403 (mutant) + AMPPNP<br />
Line 203: Line 225:
**[[5l2q]] – hChk40 kinase homology domain<br />
**[[5l2q]] – hChk40 kinase homology domain<br />
 +
 +
*'''Dclk1'''
 +
 +
**[[6kyq]] – hChk Dclk1 kinase domain<br />
 +
**[[6kyr]] – hChk Dclk1 kinase domain (mutant)<br />
 +
**[[5jzj]] – hChk Dclk1 kinase domain + AMPPN <br />
 +
**[[5jzn]], [[7kx6]], [[7kxw]] – hChk Dclk1 kinase domain + inhibitor <br />
 +
**[[7f3g]] – hChk Dclk1 kinase domain + drug <br />
 +
**[[7kx8]] – hChk Dclk1 C-terminal + inhibitor <br />
*'''Rac-α hChk (AKT1)'''; domains: pleckstrin homology 1-123; kinase 144-480
*'''Rac-α hChk (AKT1)'''; domains: pleckstrin homology 1-123; kinase 144-480
**[[1unp]], [[1unr]] – hRac-α hChk pleckstrin homology domain <br />
**[[1unp]], [[1unr]] – hRac-α hChk pleckstrin homology domain <br />
-
**[[2uzr]], [[2uzs]] – hRac-α hChk pleckstrin homology domain (mutant) <br />
+
**[[2uzr]], [[2uzs]], [[7myx]] – hRac-α hChk pleckstrin homology domain (mutant) <br />
**[[1h10]], [[1unq]], [[2uvm]] – hRac-α hChk pleckstrin homology domain + inositol tetrakisphosphate<br />
**[[1h10]], [[1unq]], [[2uvm]] – hRac-α hChk pleckstrin homology domain + inositol tetrakisphosphate<br />
-
**[[3o96]], [[4ejn]], [[6s9w]], [[6s9x]], [[6hhj]], [[6hhi]], [[6hhh]], [[6hhg]], [[6hhf]] - hRac-α hChk pleckstrin homology+kinase domains + inhibitor<br />
+
**[[3o96]], [[4ejn]], [[6s9w]], [[6s9x]], [[6hhj]], [[6hhi]], [[6hhh]], [[6hhg]], [[6hhf]] - hRac-α hChk + inhibitor<br />
-
**[[5kcv]] - hRac-α hChk (mutant) + inhibitor<br />
+
**[[5kcv]], [[7nh4]], [[7nh5]] - hRac-α hChk (mutant) + inhibitor<br />
**[[4gv1]], [[4ekl]] - hRac-α hChk kinase domain + inhibitor<br />
**[[4gv1]], [[4ekl]] - hRac-α hChk kinase domain + inhibitor<br />
**[[3qkm]], [[6ccy]] - hRac-α hChk kinase domain (mutant) + inhibitor<br />
**[[3qkm]], [[6ccy]] - hRac-α hChk kinase domain (mutant) + inhibitor<br />
-
**[[6npz]], [[6buu]] - hRac-α hChk kinase domain + bisubstrate peptide<br />
+
**[[6buu]] - hRac-α hChk kinase domain + bisubstrate peptide<br />
**[[4ekk]] - hRac-α hChk kinase domain (mutant) + GSK3 peptide + AMPPNP<br />
**[[4ekk]] - hRac-α hChk kinase domain (mutant) + GSK3 peptide + AMPPNP<br />
**[[6npz]] - hRac-α hChk kinase domain + peptide + inhibitor<br />
**[[6npz]] - hRac-α hChk kinase domain + peptide + inhibitor<br />
**[[3ow4]], [[3qkk]], [[3qkl]], [[6buu]] - hRac-α hChk kinase domain (mutant) + peptide + inhibitor<br />
**[[3ow4]], [[3qkk]], [[3qkl]], [[6buu]] - hRac-α hChk kinase domain (mutant) + peptide + inhibitor<br />
 +
**[[7apj]] - hRac-α hChk + nanobody<br />
-
*'''Rac-β hChk'''
+
*'''Rac-β hChk or AKT2'''
-
**[[1gzk]], [[1gzn]], [[1gzo]], [[1mrv]], [[1mry]] – Rac-β hChk kinase domain<br />
+
**[[1gzk]], [[1gzn]], [[1gzo]], [[1mrv]], [[1mry]] – hRac-β hChk kinase domain<br />
-
**[[1p6s]] - Rac-β hChk pleckstrin homology domain - NMR<br />
+
**[[1p6s]] - hRac-β hChk pleckstrin homology domain - NMR<br />
-
**[[1o6k]] - Rac-β hChk kinase domain + GSK3 peptide + AMPPNP<br />
+
**[[1o6k]] - hRac-β hChk kinase domain + GSK3 peptide + AMPPNP<br />
-
**[[2jdo]], [[2jdr]], [[2uw9]], [[2x39]], [[3cqu]], [[3cqw]] - Rac-β hChk kinase domain + GSK3 peptide + inhibitor<br />
+
**[[2jdo]], [[2jdr]], [[2uw9]], [[2x39]], [[3cqu]], [[3cqw]] - hRac-β hChk kinase domain + GSK3 peptide + inhibitor<br />
**[[3e87]], [[3e88]], [[3e8d]] - Rac-β hChk kinase domain (mutant) + GSK3 peptide + inhibitor<br /
**[[3e87]], [[3e88]], [[3e8d]] - Rac-β hChk kinase domain (mutant) + GSK3 peptide + inhibitor<br /
-
**[[1o6l]] - Rac-β hChk kinase domain (mutant) + GSK3 peptide + AMPPNP<br />
+
**[[1o6l]] - hRac-β hChk kinase domain (mutant) + GSK3 peptide + AMPPNP<br />
-
**[[3d0e]] - Rac-β hChk kinase domain (mutant) + inhibitor<br />
+
**[[3d0e]], [[8q61]] - hRac-β hChk kinase domain (mutant) + inhibitor<br />
-
*'''Rac-γ hChk'''
+
*'''Rac-γ hChk (AKT3)'''
**[[2x18]] – Rac-γ hChk PH domain<br />
**[[2x18]] – Rac-γ hChk PH domain<br />
Line 234: Line 266:
*'''A-Raf'''
*'''A-Raf'''
-
**[[1wxm]] – hA-Raf RAS-binding domain - NMR<br />
+
**[[1wxm]] – hA-Raf RAS-binding domain 19-91 - NMR<br />
 +
**[[2mse]] – hA-Raf RAS-binding domain + APOA-I + K-ras - NMR<br />
*'''B-Raf'''; domains - BRS 38-116; Ras-binding 153-237; kinase 445-723
*'''B-Raf'''; domains - BRS 38-116; Ras-binding 153-237; kinase 445-723
-
**[[1uwh]], [[3c4c]] – hB-Raf kinase domain + anticancer drug<br />
+
**[[8dgs]], [[8dgt]] – hB-Raf in Ras/Raf complex – Cryo EM<br />
-
**[[1uwj]] – hB-Raf kinase domain (mutant) + anticancer drug<br />
+
**[[7zr5]] – hB-Raf + Hsp90 + CDC37 + PP5 – Cryo EM<br />
-
**[[2fb8]], [[3d4q]], [[3ii5]], [[3psd]], [[3skc]], [[3tv6]], [[4g9c]], [[4ksp]], [[4ksq]], [[3psb]], [[3ppj]], [[3ppk]], [[3prf]], [[3pri]], [[3tv4]], [[4dbn]], [[4e4x]], [[4mbj]], [[4ehe]], [[3q4c]], [[3q96]], [[3e26]], [[4h58]], [[4e26]], [[4fc0]], [[4pp7]], [[6cad]] – hB-Raf kinase domain + pyrazole inhibitor<br />
+
**[[1uwh]], [[3c4c]], [[6v2u]], [[6xfp]], [[6xlo]], [[8f7o]], [[8f7p]] – hB-Raf kinase domain + anticancer drug<br />
-
**[[4jvg]], [[4ehg]], [[4fk3]], [[3idp]], [[4g9r]], [[4wo5]], [[4mnf]], [[4r5y]], [[4rzv]], [[4rzw]], [[4xv1]], [[4xv2]], [[4xv3]], [[4xv9]], [[4yht]], [[5c9c]], [[5hi2]], [[5ita]], [[5jrq]], [[5jsm]], [[5jt2]], [[6nsq]] – hB-Raf kinase domain (mutant) + pyrazole inhibitor<br />
+
**[[1uwj]], [[6p3d]] – hB-Raf kinase domain (mutant) + anticancer drug<br />
-
**[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]] - hB-Raf kinase domain + inhibitor<br />
+
**[[2fb8]], [[3d4q]], [[3ii5]], [[3psd]], [[3skc]], [[3tv6]], [[4g9c]], [[4ksp]], [[4ksq]], [[3psb]], [[3ppj]], [[3ppk]], [[3prf]], [[3pri]], [[3tv4]], [[4dbn]], [[4e4x]], [[4mbj]], [[4ehe]], [[3q4c]], [[3q96]], [[3e26]], [[4h58]], [[4e26]], [[4fc0]], [[4pp7]], [[6cad]], [[7shv]] – hB-Raf kinase domain + pyrazole inhibitor<br />
 +
**[[4jvg]], [[4ehg]], [[4fk3]], [[3idp]], [[4g9r]], [[4wo5]], [[4mnf]], [[4r5y]], [[4rzv]], [[4rzw]], [[4xv1]], [[4xv2]], [[4xv3]], [[4xv9]], [[4yht]], [[5c9c]], [[5hi2]], [[5ita]], [[5jrq]], [[5jsm]], [[5jt2]], [[6nsq]], [[6p7d]], [[6uuo]] – hB-Raf kinase domain (mutant) + pyrazole inhibitor<br />
 +
**[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]], [[7k0v]], [[7p3b]], [[7p3v]], [[8c7x]], [[8c7y]] - hB-Raf kinase domain + inhibitor<br />
 +
**[[6v34]] – hB-Raf kinase domain (mutant) + inhibitor<br />
**[[4mne]] – hB-Raf kinase domain + MAPKK1<br />
**[[4mne]] – hB-Raf kinase domain + MAPKK1<br />
 +
**[[8f7o]] – hB-Raf kinase domain + drug<br />
 +
**[[7m0u]] – hB-Raf kinase domain + AMPPNP + drug<br />
**[[6u2h]] – hB-Raf kinase domain + 14-3-3 ζ/δ<br />
**[[6u2h]] – hB-Raf kinase domain + 14-3-3 ζ/δ<br />
 +
**[[7mfe]] – hB-Raf + 14-3-3 ζ/δ – Cryo EM<br />
 +
**[[7mff]] – hB-Raf + 14-3-3 ζ/δ + inhibitor – Cryo EM<br />
 +
**[[7mfd]] – hB-Raf + 14-3-3 ζ/δ + MEK + inhibitor – Cryo EM<br />
**[[6pp9]] – hB-Raf kinase domain + MEK1 + ANP<br />
**[[6pp9]] – hB-Raf kinase domain + MEK1 + ANP<br />
 +
**[[7m0x]], [[7m0z]] – hB-Raf kinase domain + MEK1 + ANP + inhibitor<br />
 +
**[[7m0t]], [[7m0u]], [[7m0v]], [[7m0w]], [[7m0y]] – hB-Raf kinase domain + MEK1 + ANP + drug<br />
**[[6u2g]] – hB-Raf kinase domain + MEK1 + AMPPCP<br />
**[[6u2g]] – hB-Raf kinase domain + MEK1 + AMPPCP<br />
**[[5vr3]] – hB-Raf BRS domain <br />
**[[5vr3]] – hB-Raf BRS domain <br />
 +
**[[7jhp]] – hB-Raf BRS domain + Hras<br />
 +
**[[6ntc]], [[6ntd]] – hB-Raf BRS domain (mutant) + Hras<br />
 +
**[[6xi7]] – hB-Raf 52-188 + Kras<br />
**[[2l05]], [[5j17]], [[5j2r]] – hB-Raf RAS-binding domain - NMR<br />
**[[2l05]], [[5j17]], [[5j2r]] – hB-Raf RAS-binding domain - NMR<br />
**[[3ny5]] – hB-Raf RAS-binding domain <br />
**[[3ny5]] – hB-Raf RAS-binding domain <br />
**[[5j18]] – hB-Raf RAS-binding domain + inhibitor - NMR<br />
**[[5j18]] – hB-Raf RAS-binding domain + inhibitor - NMR<br />
 +
**[[6pts]], [[6ptw]] – hB-Raf 56-187 + Kras + apolipoprotein + GMPPNP - NMR<br />
**[[6uan]], [[6q0k]] – hB-Raf + 14-3-3 ζ – Cryo EM<br />
**[[6uan]], [[6q0k]] – hB-Raf + 14-3-3 ζ – Cryo EM<br />
**[[6nyb]] – hB-Raf + 14-3-3 ζ + MEK1 – Cryo EM<br />
**[[6nyb]] – hB-Raf + 14-3-3 ζ + MEK1 – Cryo EM<br />
Line 269: Line 316:
**[[4g0n]], [[4g3x]] – hc-Raf RAS-binding domain + GTPase Hras <br />
**[[4g0n]], [[4g3x]] – hc-Raf RAS-binding domain + GTPase Hras <br />
**[[3kud]] – hc-Raf RAS-binding domain (mutant) + GTPase Hras <br />
**[[3kud]] – hc-Raf RAS-binding domain (mutant) + GTPase Hras <br />
 +
**[[8epw]] – hc-Raf RAS-binding domain + GTPase Kras <br />
 +
**[[8atr]], [[8ats]], [[8avo]] – hc-Raf RAS-binding domain + 14-3-3 protein sigma <br />
 +
**[[6xgu]], [[6xgv]], [[6xha]], [[6xhb]] – hc-Raf RBD+CRD domains 52-188 + GTPase Kras + GMPPNP<br />
 +
**[[7z5r]], [[8gae]] – hc-Raf RBD domain + Hsp84 + Cdc37 + PP5 + ADP + ATP – Cryo EM<br />
 +
**[[7zr0]] – hc-Raf RBD domain + Hsp84 + Cdc37 + ATP – Cryo EM<br />
*'''Snf1-related Chk'''
*'''Snf1-related Chk'''
Line 278: Line 330:
*'''MAPK-interacting Chk''' or Mnk1 Mnk2
*'''MAPK-interacting Chk''' or Mnk1 Mnk2
-
**[[2hw6]] – hChk 1 catalytic domain<br />
+
**[[2hw6]] – hMnk 1 catalytic domain<br />
-
**[[2hw7]] – hChk 1 catalytic domain + staurosporin<br />
+
**[[2hw7]] – hMnk 1 catalytic domain + staurosporin<br />
-
**[[5wvd]] – hChk 1 catalytic domain + inhibitor<br />
+
**[[5wvd]] – hMnk 1 catalytic domain + inhibitor<br />
-
**[[2ac3]] – hChk 2 catalytic domain<br />
+
**[[2ac3]] – hMnk 2 catalytic domain<br />
-
**[[2ac5]] – hChk 2 catalytic domain (mutant)<br />
+
**[[2ac5]] – hMnk 2 catalytic domain (mutant)<br />
-
**[[6cj5]], [[6cje]], [[6cjh]], [[6cjw]], [[6cjy]], [[6ck3]], [[6ck6]], [[6cki]] – hChk 2 catalytic domain (mutant) + inhibitor<br />
+
**[[6cj5]], [[6cje]], [[6cjh]], [[6cjw]], [[6cjy]], [[6ck3]], [[6ck6]], [[6cki]] – hMnk 2 catalytic domain (mutant) + inhibitor<br />
-
*'''hChk Pak''' or '''Chk N''' or '''PRK1''';Domains - CRIB 74-109; Hr1B 122-199; kinase 605-942
+
*'''hChk Pak''' or '''Chk N''' or '''PRK1''';Domains - CRIB 74-109; Hr1B 122-199; catalytic 109-426; kinase 605-942
**[[1urf]] – hChk Pak-1 Hr1b domain - NMR<br />
**[[1urf]] – hChk Pak-1 Hr1b domain - NMR<br />
Line 293: Line 345:
**[[4otd]] - hChk Pak-1 kinase domain<br />
**[[4otd]] - hChk Pak-1 kinase domain<br />
**[[1yhv]], [[1yhw]], [[3q4z]], [[3q52]], [[3q53]] – hChk Pak-1 kinase domain (mutant)<br />
**[[1yhv]], [[1yhw]], [[3q4z]], [[3q52]], [[3q53]] – hChk Pak-1 kinase domain (mutant)<br />
-
**[[4o0r]], [[4o0t]], [[4zji]], [[4zjj]], [[4zlo]], [[4zy4]], [[4zy5]], [[4zy7]], [[5ime]], [[5kbq]], [[5kbr]], [[6b16]] – hChk Pak-1 kinase domain + inhibitor<br />
+
**[[4o0r]], [[4o0t]], [[4zji]], [[4zjj]], [[4zlo]], [[4zy4]], [[4zy5]], [[4zy7]], [[5ime]], [[5kbq]], [[5kbr]], [[6b16]], [[7vto]] – hChk Pak-1 kinase domain + inhibitor<br />
**[[4oti]], [[4oth]], [[4otg]] – hChk Pak-1 kinase domain + inhibitor<br />
**[[4oti]], [[4oth]], [[4otg]] – hChk Pak-1 kinase domain + inhibitor<br />
**[[4eqc]], [[4p90]], [[5dew]], [[5dey]], [[5dfp]] – hChk Pak-1 kinase domain (mutant) + inhibitor<br />
**[[4eqc]], [[4p90]], [[5dew]], [[5dey]], [[5dfp]] – hChk Pak-1 kinase domain (mutant) + inhibitor<br />
Line 304: Line 356:
**[[2cdz]] – hChk Pak-4 + purine derivative<br />
**[[2cdz]] – hChk Pak-4 + purine derivative<br />
**[[2ov2]] – hChk Pak-4 CRIB domain + RAC3<br />
**[[2ov2]] – hChk Pak-4 CRIB domain + RAC3<br />
-
**[[2qon]], [[4fif]], [[4fih]], [[4fii]], [[4jdh]], [[4jdi]], [[4jdj]], [[4jdk]] – hChk Pak-4 kinase domain + peptide<br />
+
**[[2qon]], [[4fif]], [[4fih]], [[4fii]], [[4jdh]], [[4jdi]], [[4jdj]], [[4jdk]], [[6wlx]], [[6wly]] – hChk Pak-4 kinase domain + peptide<br />
-
**[[4app]], [[4o0v]], [[4o0x]], [[4o0y]], [[4njd]], [[4xbu]], [[5bms]], [[5i0b]], [[5vee]], [[5vef]], [[5zjw]], [[5xvg]], [[5xvf]], [[5xva]] – hChk Pak-4 kinase domain + inhibitor<br />
+
**[[4app]], [[4o0v]], [[4o0x]], [[4o0y]], [[4njd]], [[4xbu]], [[5bms]], [[5i0b]], [[5vee]], [[5vef]], [[5zjw]], [[5xvg]], [[5xvf]], [[5xva]], [[7cmb]], [[7cp3]], [[7cp4]] – hChk Pak-4 kinase domain + inhibitor<br />
**[[2x4z]], [[2xh5]] – hChk Pak-4 kinase domain (mutant) + inhibitor<br />
**[[2x4z]], [[2xh5]] – hChk Pak-4 kinase domain (mutant) + inhibitor<br />
**[[5upl]], [[5upk]] – hChk Pak-4 kinase domain (mutant) + CDC42<br />
**[[5upl]], [[5upk]] – hChk Pak-4 kinase domain (mutant) + CDC42<br />
**[[5ved]] – hChk Pak-4 kinase domain + staurosporine<br />
**[[5ved]] – hChk Pak-4 kinase domain + staurosporine<br />
 +
**[[8ahi]] – hChk Pak-4 300-591 + inhibitor<br />
 +
**[[7s46]], [[7s48]] – hChk Pak-4 catalytic domain + integrin beta-5 peptide<br />
**[[2c30]] – hChk Pak-6<br />
**[[2c30]] – hChk Pak-6<br />
**[[2odb]] – hChk Pak-6 CRIB domain + CDC42<br />
**[[2odb]] – hChk Pak-6 CRIB domain + CDC42<br />
Line 333: Line 387:
**[[1rwi]], [[1rwl]] - MtChk PknD extracellular domain<br />
**[[1rwi]], [[1rwl]] - MtChk PknD extracellular domain<br />
**[[2h34]] – MtChk PknE catalytic domain<br />
**[[2h34]] – MtChk PknE catalytic domain<br />
 +
**[[7naa]] – MtChk PknF kinase domain + inhibitor<br />
**[[4y12]] - MtChk PknG + ATP-gS<br />
**[[4y12]] - MtChk PknG + ATP-gS<br />
**[[4y0x]] - MtChk PknG + ADP<br />
**[[4y0x]] - MtChk PknG + ADP<br />
 +
**[[7q52]] - MtChk PknG + inhibitor<br />
**[[4esq]] - MtChk PknH extracellular domain<br />
**[[4esq]] - MtChk PknH extracellular domain<br />
**[[5m06]], [[5xka]] - MtChk PknI kinase domain <br />
**[[5m06]], [[5xka]] - MtChk PknI kinase domain <br />
**[[5m07]], [[5m08]], [[5m09]] - MtChk PknI kinase domain (mutant)<br />
**[[5m07]], [[5m08]], [[5m09]] - MtChk PknI kinase domain (mutant)<br />
**[[5xlm]], [[5xll]] - MtChk PknI sensor domain <br />
**[[5xlm]], [[5xll]] - MtChk PknI sensor domain <br />
 +
**[[7mxb]], [[7mxj]], [[7mxk]] - Chk PknG kinase domain + AMPPNP - ''Corynebacterium glutamicum''<br />
*'''hChk Nek'''
*'''hChk Nek'''
Line 345: Line 402:
**[[4b9d]] - hChk Nek1 kinase domain (mutant) + inhibitor<br />
**[[4b9d]] - hChk Nek1 kinase domain (mutant) + inhibitor<br />
**[[2w5h]] – hChk Nek2 kinase domain<br />
**[[2w5h]] – hChk Nek2 kinase domain<br />
-
**[[2jav]], [[2wqo]], [[2xk3]], [[2xk4]], [[2xk6]], [[2xk7]], [[2xk8]], [[2xkc]], [[2xkd]], [[2xke]], [[2xkf]], [[2xnm]], [[2xnn]], [[2xno]], [[2xnp]], [[4a4x]], [[4afe]], [[5m51]], [[5m53]], [[5m55]], [[5m57]], [[6sk9]] – hChk Nek2 + inhibitor<br />
+
**[[2jav]], [[2wqo]], [[2xk3]], [[2xk4]], [[2xk6]], [[2xk7]], [[2xk8]], [[2xkc]], [[2xkd]], [[2xke]], [[2xkf]], [[2xnm]], [[2xnn]], [[2xno]], [[2xnp]], [[4a4x]], [[4afe]], [[5m51]], [[5m53]], [[5m55]], [[5m57]], [[6sgd]], [[6sk9]], [[6sgh]], [[6sgi]], [[6sgk]], [[8sk9]] – hChk Nek2 + inhibitor<br />
**[[2w5a]], [[2w5b]] – hChk Nek2 + nucleotide<br />
**[[2w5a]], [[2w5b]] – hChk Nek2 + nucleotide<br />
-
**[[2wqm]] – hChk Nek7<br />
+
**[[6tm5]] - hChk Nek2 in anaphase-promoting complex – Cryo EM<br />
 +
**[[2wqm]], [[6s76]] – hChk Nek7<br />
**[[2wqn]] – hChk Nek7 + ADP<br />
**[[2wqn]] – hChk Nek7 + ADP<br />
**[[5de2]] – hChk Nek7 + hChk Nek9<br />
**[[5de2]] – hChk Nek7 + hChk Nek9<br />
**[[6s73]], [[2wqo]] – hChk Nek7 + inhibitor<br />
**[[6s73]], [[2wqo]] – hChk Nek7 + inhibitor<br />
 +
**[[6npy]] – hChk Nek7 + Nlrp3<br />
 +
**[[6s75]] – hChk Nek7 + inhibitor<br />
 +
 +
*'''Chk Rio'''
 +
 +
**[[6fdo]], [[6fdn]], [[6fdm]] – hChk Rio2 <br />
 +
**[[4otp]] – hChk Rio1 Rio domain + ADP <br />
 +
**[[6hk6]], [[7vbt]] – hChk Rio2 + inhibitor <br />
 +
**[[6eml]], [[6fai]], [[6g18]], [[6g51]], [[6rbd]],[[6rbe]], [[6y7c]] – yChk Rio2 in 40S particle – Cryo EM<br />
 +
**[[1ztf]] – AfChk Rio1 + adenine derivative – ''Archaeoglobus fulgidus''<br />
 +
**[[1zth]] – AfChk Rio1 + ADP <br />
 +
**[[1zp9]] – AfChk Rio1 + ATP <br />
 +
**[[1tqp]], [[1zao]] – AfChk Rio2 + ATP <br />
 +
**[[1zar]] – AfChk Rio2 + ADP <br />
 +
**[[4gyg]] – CtChk Rio2 – ''Chaetonium thermophilum''<br />
 +
**[[4gyi]] – CtChk Rio2 + ADP <br />
*hChk Vrk (vaccinia-related kinase)
*hChk Vrk (vaccinia-related kinase)
Line 357: Line 431:
**[[3op5]] – hChk Vrk1 kinase domain (mutant)<br />
**[[3op5]] – hChk Vrk1 kinase domain (mutant)<br />
**[[5ukf]] – hChk Vrk1 kinase domain + inhibitor<br />
**[[5ukf]] – hChk Vrk1 kinase domain + inhibitor<br />
-
**[[5uvf]], [[6cnx]], [[6bu6]], [[6cfm]], [[6dd4]], [[6bp0]], [[6bru]], [[6btw]], [[6cmm]], [[6cqh]], [[6csw]] – hChk Vrk1 kinase domain (mutant) + inhibitor<br />
+
**[[5uvf]], [[6cnx]], [[6bu6]], [[6cfm]], [[6dd4]], [[6bp0]], [[6bru]], [[6btw]], [[6cmm]], [[6cqh]], [[6csw]], [[6npn]], [[6vxu]], [[6vzh]] – hChk Vrk1 kinase domain (mutant) + inhibitor<br />
**[[6ac9]] – hChk Vrk1 kinase domain (mutant) + AMPPNP<br />
**[[6ac9]] – hChk Vrk1 kinase domain (mutant) + AMPPNP<br />
 +
**[[7tan]] – hChk Vrk1 kinase domain + nucleosome – Cryo EM<br />
**[[2v62]] – hChk Vrk2 kinase domain <br />
**[[2v62]] – hChk Vrk2 kinase domain <br />
-
**[[5uu1]], [[6ncg]] – hChk Vrk2 kinase domain + inhibitor<br />
+
**[[5uu1]], [[6ncg]], [[8q1z]] – hChk Vrk2 kinase domain + inhibitor<br />
-
*Chk Wnk (protein kinase lysine-deficient)
+
*Chk Wnk (protein kinase lysine-deficient); Domains - kinase 194-483; CCT1 454-549
**[[6cn9]], [[4q2a]], [[4pwn]] - hChk Wnk1 kinase domain (mutant)<br />
**[[6cn9]], [[4q2a]], [[4pwn]] - hChk Wnk1 kinase domain (mutant)<br />
Line 368: Line 443:
**[[5wdy]], [[5we8]] - hChk Wnk1 kinase domain + inhibitor + ANP<br />
**[[5wdy]], [[5we8]] - hChk Wnk1 kinase domain + inhibitor + ANP<br />
**[[6elm]] - hChk Wnk2 CCT1 domain <br />
**[[6elm]] - hChk Wnk2 CCT1 domain <br />
-
**[[5drb]] - rChk Wnk1 kinase domain (mutant) + inhibitor<br />
+
**[[5drb]], [[6ol2]] - rChk Wnk1 kinase domain (mutant) + inhibitor<br />
-
**[[6fbk]] - hChk Wnk2 CCT1 domain + AMPPNP <br />
+
**[[6fbk]] - hChk Wnk2 CCT1 domain + Wnk1 peptide <br />
**[[5o1v]], [[5o21]], [[5o23]] - hChk Wnk3 kinase domain <br />
**[[5o1v]], [[5o21]], [[5o23]] - hChk Wnk3 kinase domain <br />
**[[5o2c]] - hChk Wnk3 kinase + CCT1 domains <br />
**[[5o2c]] - hChk Wnk3 kinase + CCT1 domains <br />
**[[5o26]], [[5tf9]] - hChk Wnk3 kinase domain + AMPPNP<br />
**[[5o26]], [[5tf9]] - hChk Wnk3 kinase domain + AMPPNP<br />
**[[5o2b]] - hChk Wnk3 kinase domain + inhibitor<br />
**[[5o2b]] - hChk Wnk3 kinase domain + inhibitor<br />
-
**[[2lru]] – rChk Wnk1 autoinhibitory domain - NMR<br />
+
**[[8edh]] - hChk Wnk3 kinase domain (mutant) + inhibitor<br />
 +
**[[2lru]] – rChk Wnk1 autoinhibitory domain 480-572 - NMR<br />
**[[5w7t]] - rChk Wnk1 kinase domain <br />
**[[5w7t]] - rChk Wnk1 kinase domain <br />
 +
**[[7uos]] - rChk Wnk1 kinase domain (mutant)<br />
*'''TANK-binding kinase'''
*'''TANK-binding kinase'''
**[[4efo]] – hChk Tbk1 ubiquitin-like domain <br />
**[[4efo]] – hChk Tbk1 ubiquitin-like domain <br />
-
**[[6rsr]] – hChk Tbk1 + inhibitor <br />
+
**[[6rsr]], [[6rsu]] – hChk Tbk1 + inhibitor <br />
**[[4im0]], [[4im2]], [[4im3]], [[4iw0]], [[4iwo]], [[4iwp]], [[4ipq]], [[6rst]] – hChk Tbk1 (mutant) + inhibitor <br />
**[[4im0]], [[4im2]], [[4im3]], [[4iw0]], [[4iwo]], [[4iwp]], [[4ipq]], [[6rst]] – hChk Tbk1 (mutant) + inhibitor <br />
**[[6cq5]], [[6cq4]], [[6cq0]], [[6boe]], [[6bod]], [[6bny]], [[5w5v]] – hChk Tbk1 + ulcer drug<br />
**[[6cq5]], [[6cq4]], [[6cq0]], [[6boe]], [[6bod]], [[6bny]], [[5w5v]] – hChk Tbk1 + ulcer drug<br />
Line 393: Line 470:
**[[2vuw]], [[2wb8]] – hChk Haspin kinase domain <br />
**[[2vuw]], [[2wb8]] – hChk Haspin kinase domain <br />
**[[3dle]] – hChk Haspin kinase domain + AMP<br />
**[[3dle]] – hChk Haspin kinase domain + AMP<br />
-
**[[3e7v]], [[3f2n]], [[3fmd]], [[3iq7]], [[4qtc]], [[5htb]], [[5htc]] – hChk Haspin kinase domain + inhibitor<br />
+
**[[3e7v]], [[3f2n]], [[3fmd]], [[3iq7]], [[4qtc]], [[5htb]], [[5htc]], [[6z56]], [[6z57]], [[6z58]], [[6z59]], [[6z5a]], [[6z5b]], [[6z5c]]. [[6z5d]], [[6z5e]], [[7avq]], [[7ops]] – hChk Haspin kinase domain + inhibitor<br />
 +
**[[7sqm]] – hChk Haspin kinase domain + antimalarial<br />
**[[6g38]], [[6g34]], [[6g35]], [[6g36]], [[6g37]] – hChk Haspin kinase domain + tubercidin derivative<br />
**[[6g38]], [[6g34]], [[6g35]], [[6g36]], [[6g37]] – hChk Haspin kinase domain + tubercidin derivative<br />
**[[6g39]], [[6g3a]] – hChk Haspin kinase domain (mutant) + tubercidin derivative<br />
**[[6g39]], [[6g3a]] – hChk Haspin kinase domain (mutant) + tubercidin derivative<br />
Line 407: Line 485:
**[[2qnj]] – hChk MARK3 catalytic+UBA domains <br />
**[[2qnj]] – hChk MARK3 catalytic+UBA domains <br />
**[[3fe3]] – hChk MARK3 catalytic+UBA domains (mutant)<br />
**[[3fe3]] – hChk MARK3 catalytic+UBA domains (mutant)<br />
 +
**[[7p1l]] – hChk MARK3 catalytic+UBA domains + inhibitor <br />
**[[5es1]] – hChk MARK4 catalytic+UBA domains + inhibitor<br />
**[[5es1]] – hChk MARK4 catalytic+UBA domains + inhibitor<br />
**[[1zmu]] – rChk MARK2 catalytic+UBA domains <br />
**[[1zmu]] – rChk MARK2 catalytic+UBA domains <br />
Line 420: Line 499:
**[[6f7b]] – hChk Bub1 kinase domain + inhibitor<br />
**[[6f7b]] – hChk Bub1 kinase domain + inhibitor<br />
**[[4a1g]] – hChk Bub1 TPR domain + CASC5 KI motif<br />
**[[4a1g]] – hChk Bub1 TPR domain + CASC5 KI motif<br />
 +
**[[4ggd]] - hChk Bub1 + cell division cycle protein<br />
 +
**[[6tlj]], [[5khu]] - hChk Bub1 in anaphase-promoting complex – Cryo EM<br />
 +
**[[6jkk]] – DmChk Bub1 kinase domain <br />
 +
**[[6jkm]] – DmChk Bub1 kinase domain + ADP<br />
**[[5jja]] – hChk Bub1 residues 661-734 + PP2A<br />
**[[5jja]] – hChk Bub1 residues 661-734 + PP2A<br />
**[[3esl]] – yChk Bub1 N terminal <br />
**[[3esl]] – yChk Bub1 N terminal <br />
Line 440: Line 523:
**[[1aue]] – hFRAP FRB domain<BR />
**[[1aue]] – hFRAP FRB domain<BR />
**[[2gaq]], [[2npu]] – hFRAP FRB domain - NMR<BR />
**[[2gaq]], [[2npu]] – hFRAP FRB domain - NMR<BR />
 +
**[[8ppz]] – hFRAP FRB domain + FKBP + pyridine derivative<BR />
**[[3fap]], [[2fap]], [[4fap]] – hFRAP FRB domain + FKBP + rapamycin analog<BR />
**[[3fap]], [[2fap]], [[4fap]] – hFRAP FRB domain + FKBP + rapamycin analog<BR />
**[[4drh]], [[4dri]], [[4drj]], [[5gpg]] – hFRAP FRB domain + FKBP + rapamycin<BR />
**[[4drh]], [[4dri]], [[4drj]], [[5gpg]] – hFRAP FRB domain + FKBP + rapamycin<BR />
 +
**[[6m4u]], [[6m4w]] – hChk Mtor FRB domain (mutant) + FKBP1A + rapamycin <br />
**[[5wbh]] – hFRAP FRB domain + S6K1 peptide <br />
**[[5wbh]] – hFRAP FRB domain + S6K1 peptide <br />
-
*''mTOR domain residues 1376-2549''
+
*''mTOR FAT+PIKK domain residues 1376-2549''
**[[4jsn]] – hFRAP + TORC subunit LST8<BR />
**[[4jsn]] – hFRAP + TORC subunit LST8<BR />
Line 461: Line 546:
**[[6sb0]] – hChk Mtor + RAPTOR + LST8 + RAGA + RAGC + proline-rich Akt1 substrate – Cryo EM <br />
**[[6sb0]] – hChk Mtor + RAPTOR + LST8 + RAGA + RAGC + proline-rich Akt1 substrate – Cryo EM <br />
**[[5zcs]] – hmTOR + LST8 + AVO3 + TORC2 – Cryo EM <br />
**[[5zcs]] – hmTOR + LST8 + AVO3 + TORC2 – Cryo EM <br />
 +
**[[7tzo]] – hTORC2 in mTORC2 complex– Cryo EM <br />
 +
**[[6zwm]], [[6zwo]], [[7owg]], [[7pe7]], [[7pe8]], [[7pe9]], [[7pea]], [[7peb]], [[7pec]], [[7uxc]], [[8era]] – mTOR in mTor complex – Cryo EM <br />
*'''Gcn2'''
*'''Gcn2'''
Line 470: Line 557:
**[[1zyd]] – yChk Gcn2 + ATP<br />
**[[1zyd]] – yChk Gcn2 + ATP<br />
**[[4otn]] – mChk Gcn2 C terminal domain <br />
**[[4otn]] – mChk Gcn2 C terminal domain <br />
 +
 +
*'''LRRK1''' or leucine-rich repeat Chk1
 +
 +
**[[8e04]], [[8e05]], [[8e06]], [[8fac]] – hLRRK1 – Cryo EM <br />
 +
 +
*'''LRRK2''' or leucine-rich repeat Chk2 or dardarin
 +
 +
**[[6xr4]] – hLRRK2 – Cryo EM <br />
 +
**[[7lht]], [[7lhw]], [[7li4]] – hLRRK2 + ATP + GDP – Cryo EM <br />
 +
**[[7li3]] – hLRRK2 (mutant) + ATP + GDP – Cryo EM <br />
 +
**[[6oje]], [[7thy]] – hLRRK2 GTPase domain 1329-1520<br />
 +
**[[6ojf]] – hLRRK2 GTPase domain (mutant) <br />
 +
**[[6dlo]], [[6dlp]] – hLRRK2 WD40 domain<br />
 +
**[[7thz]] – hLRRK2 1330-1527 + GDP <br />
 +
**[[6vno]], [[6vp6]], [[6vp7]] – hLRRK2 C terminal 1330-2527 – Cryo EM <br />
 +
**[[6vp8]] – hLRRK2 C terminal 1330-2527 + COR domain 1670-1950 + WD40 domain 2140-2489 – Cryo EM <br />
 +
**[[6s6q]] – AtLRRK2 ectodomain + protein casparian strip peptide <br />
*'''Pim'''
*'''Pim'''
-
*Pim1; Domains catalytic 14-313; kinase 92-404
+
*Pim1 catalytic domain residues 14-313
-
**[[1xqz]], [[1ywv]], [[4jx3]] – hPim1 catalytic domain – human <br />
+
**[[1xqz]], [[1ywv]], [[4jx3]] – hPim1 catalytic domain <br />
**[[1yxs]] – hPim1 catalytic domain (mutant) <br />
**[[1yxs]] – hPim1 catalytic domain (mutant) <br />
-
**[[4jx3]] – hPim1 kinase domain <br />
 
**[[1xr1]], [[1yxt]] – hPim1 catalytic domain + AMPPNP <br />
**[[1xr1]], [[1yxt]] – hPim1 catalytic domain + AMPPNP <br />
**[[1yxu]] – hPim1 catalytic domain + AMP <br />
**[[1yxu]] – hPim1 catalytic domain + AMP <br />
-
**[[1yxv]] – hPim1 catalytic domain + quinoline derivative <br />
+
**[[1yxv]], [[5ipj]] – hPim1 catalytic domain + quinoline derivative <br />
-
**[[3uix]] – hPim1 kinase domain residues 120-404 + quinoline derivative <br />
+
**[[1yxx]] – hPim1 catalytic domain + indole derivative <br />
**[[1yxx]] – hPim1 catalytic domain + indole derivative <br />
-
**[[3a99]] – hPim1 kinase domain + phosphoaminophosphonic acid adenylate <br />
 
**[[2bzj]], [[2bzh]], [[2bzi]] – hPim1 catalytic domain (mutant) + organometallic ligand <br />
**[[2bzj]], [[2bzh]], [[2bzi]] – hPim1 catalytic domain (mutant) + organometallic ligand <br />
 +
**[[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3c4e]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[3umw]], [[3umx]], [[4enx]], [[4eny]], [[4k1b]], [[4k18]], [[4k0y]], [[4iaa]], [[4i41]], [[4ll5]], [[4lm5]], [[4lmu]], [[4mta]], [[6kzi]], [[4mbl]], [[4mbi]], [[4n6y]], [[4n6z]], [[4n70]], [[4xh6]], [[5iis]], [[5kgd]], [[5kge]], [[5kgg]], [[5kgi]], [[5kgk]], [[5kzi]], [[5vua]], [[5vub]], [[5vuc]], [[6mt0]], [[6vrv]], [[7oov]], [[7oow]], [[7oox]], [[7xsv]] – hPim1 catalytic domain + inhibitor <br />
 +
**[[2j2i]], [[3we8]] – hPim1 catalytic domain (mutant)+ inhibitor <br />
 +
 +
*Pim1 kinase domain residues 92-404
 +
 +
**[[4jx3]] – hPim1 kinase domain <br />
 +
**[[3uix]], [[5c1q]] – hPim1 kinase domain residues 120-404 + quinoline derivative <br />
 +
**[[3a99]] – hPim1 kinase domain + phosphoaminophosphonic acid adenylate <br />
**[[2oi4]], [[3bwf]] – hPim1 kinase domain (mutant) + organometallic ligand <br />
**[[2oi4]], [[3bwf]] – hPim1 kinase domain (mutant) + organometallic ligand <br />
-
**[[1xws]], [[4dtk]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]], [[6bsk]], [[5v80]], [[5v82]]. [[5toe]], [[5tex]], [[5tel]], [[5o11]], [[5o12]], [[5o13]], [[6no8]], [[6no9]] – hPim1 kinase domain + inhibitor <br />
+
**[[1xws]], [[4alu]], [[4alv]], [[4alw]], [[4as0]], [[4bzn]], [[4bzo]], [[4dtk]], [[4jx7]], [[4rbl]], [[4rc2]], [[4rc3]], [[4rc4]], [[4ty1]], [[4wrs]], [[4wsy]], [[4wt6]], [[4xhk]], [[[5dgz]], [5dhj]], [[5dia]], [[5dwr]], [[5eol]], [[5kcx]], [[5o11]], [[5o12]], [[5o13]], [[5tel]], [[5tex]], [[5toe]], [[5v80]], [[5v82]]. [[6bsk]], [[6l11]], [[6l12]], [[6l13]], [[6l14]], [[6l15]], [[6l16]], [[6l17]], [[6no8]], [[6no9]], [[6vru]], [[6ykd]], [[7zun]] – hPim1 kinase domain + inhibitor <br />
**[[6ayd]] – hPim1 kinase domain (mutant)+ inhibitor <br />
**[[6ayd]] – hPim1 kinase domain (mutant)+ inhibitor <br />
-
**[[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4ll5]], [[4lm5]], [[3c4e]], [[5vuc]], [[5vub]], [[5vua]], [[4n70]], [[4n6z]], [[4n6y]], [[4mta]], [[4med]], [[4mbl]], [[4mbi]], [[4lmu]], [[4k1b]], [[4k18]], [[4k0y]], [[4iaa]], [[4i41]], [[6mt0]] – hPim1 catalytic domain + inhibitor <br />
 
-
**[[2j2i]], [[3we8]] – hPim1 catalytic domain (mutant)+ inhibitor <br />
 
-
**[[5tur]] - hPim1 + inhibitor <br />
 
-
*Pim1 complex with consensus peptide
+
*Pim1 full length
 +
 
 +
**[[4rpv]], [[5tur]] - hPim1 + inhibitor <br />
 +
 
 +
*Pim1 complex with consensus peptide (pimtide)
**[[2bil]], [[3cxw]], [[3cy2]], [[3cy3]], [[6qxk]], [[6pcw]], [[6pdi]], [[6pdn]], [[6pdo]], [[6pdp]] – hPim1 kinase domain + inhibitor + consensus peptide<br />
**[[2bil]], [[3cxw]], [[3cy2]], [[3cy3]], [[6qxk]], [[6pcw]], [[6pdi]], [[6pdn]], [[6pdo]], [[6pdp]] – hPim1 kinase domain + inhibitor + consensus peptide<br />
**[[3jpv]], [[3qf9]] - hPim1 catalytic domain + inhibitor + consensus peptide<br />
**[[3jpv]], [[3qf9]] - hPim1 catalytic domain + inhibitor + consensus peptide<br />
**[[2c3i]], [[5ndt]], [[5n5m]], [[5n5l]], [[5n52]], [[5n51]], [[5n50]], [[5n4z]], [[5n4y]], [[5n4x]], [[5n4v]], [[5n4u]], [[5n4r]], [[5n4o]], [[5n4n]], [[5mzl]] – hPim1 kinase domain (mutant) + inhibitor + consensus peptide <br />
**[[2c3i]], [[5ndt]], [[5n5m]], [[5n5l]], [[5n52]], [[5n51]], [[5n50]], [[5n4z]], [[5n4y]], [[5n4x]], [[5n4v]], [[5n4u]], [[5n4r]], [[5n4o]], [[5n4n]], [[5mzl]] – hPim1 kinase domain (mutant) + inhibitor + consensus peptide <br />
-
**[[4gw8]] – hPim1 catalytic domain (mutant) + inhibitor + consensus peptide <br />
+
**[[4gw8]], [[7qb2]], [[7qfm]], [[7z6u]], [[8afr]] – hPim1 catalytic domain (mutant) + inhibitor + pimtide<br />
**[[2bzk]] – hPim1 kinase domain (mutant)+ AMPPNP + consensus peptide <br />
**[[2bzk]] – hPim1 kinase domain (mutant)+ AMPPNP + consensus peptide <br />
**[[3ma3]] – hPim1 catalytic domain + inhibitor + PSer + consensus peptide<br />
**[[3ma3]] – hPim1 catalytic domain + inhibitor + PSer + consensus peptide<br />
Line 511: Line 621:
**[[4x7q]] – hPim2 catalytic domain + inhibitor<br />
**[[4x7q]] – hPim2 catalytic domain + inhibitor<br />
 +
**[[2iwi]] – hPim2 catalytic domain + Ru ligand<br />
-
*'''Rip or receptor-interacting Chk; Domains – catalytic 1-294; Death 561-671'''
+
*'''Rip or receptor-interacting Chk; Domains – catalytic 1-294; Amyloid fibril 418-518; Death 561-671'''
**[[6ac5]] – hRip1 death domain <br />
**[[6ac5]] – hRip1 death domain <br />
-
**[[6r5f]], [[6nw2]], [[6c4d]], [[6c3e]], [[5tx5]] – hRip1 catalytic domain + inhibitor <br />
+
**[[6r5f]], [[6nw2]], [[6c4d]], [[6c3e]], [[5tx5]], [[7fcz]], [[7fd0]], [[7ydx]] – hRip1 catalytic domain + inhibitor <br />
**[[6rln]], [[6ocq]], [[6nyh]], [[6hho]] – hRip1 catalytic domain (mutant) + inhibitor <br />
**[[6rln]], [[6ocq]], [[6nyh]], [[6hho]] – hRip1 catalytic domain (mutant) + inhibitor <br />
**[[6ggs]] – hRip2 – Cryo EM <br />
**[[6ggs]] – hRip2 – Cryo EM <br />
Line 521: Line 632:
**[[6szj]], [[6sze]], [[6s1f]], [[6rna]], [[6rn8]], [[6hmx]], [[6fu5]], [[6es0]], [[5w5o]], [[5w5j]] – hRip2 catalytic domain + inhibitor <br />
**[[6szj]], [[6sze]], [[6s1f]], [[6rna]], [[6rn8]], [[6hmx]], [[6fu5]], [[6es0]], [[5w5o]], [[5w5j]] – hRip2 catalytic domain + inhibitor <br />
**[[6ul8]] – hRip2 catalytic domain (mutant) + inhibitor <br />
**[[6ul8]] – hRip2 catalytic domain (mutant) + inhibitor <br />
 +
**[[8aza]] – hRip2 catalytic domain + XiaP Bir2 domain – Cryo EM <br />
 +
**[[7mx3]] – hRip3 catalytic domain (mutant) + inhibitor <br />
 +
**[[7mon]] – hRip3 catalytic domain (mutant) + MLKL <br />
 +
**[[7dac]] – hRip3 amyloid fibril - NMR <br />
 +
**[[7da4]] – hRip3 amyloid fibril – Cryo EM<br />
**[[6oko]] – mRip3 catalytic domain + inhibitor <br />
**[[6oko]] – mRip3 catalytic domain + inhibitor <br />
 +
**[[6jpd]] – mRip3 residues 409-486 - NMR <br />
**[[5wnm]], [[5wnj]] – mRip4 catalytic domain (mutant) + drug <br />
**[[5wnm]], [[5wnj]] – mRip4 catalytic domain (mutant) + drug <br />
**[[5wnl]] – mRip4 catalytic domain (mutant) + staurosporine <br />
**[[5wnl]] – mRip4 catalytic domain (mutant) + staurosporine <br />
Line 533: Line 650:
**[[5ci7]], [[6mnh]] – hChk Ulk1 (mutant) + inhibitor<br />
**[[5ci7]], [[6mnh]] – hChk Ulk1 (mutant) + inhibitor<br />
**[[4wnp]], [[4wno]] – hChk Ulk1 + IST1 homolog<br />
**[[4wnp]], [[4wno]] – hChk Ulk1 + IST1 homolog<br />
-
**[[6qav]], [[6qau]], [[6qat]] – hChk Ulk2 + inhibitor<br />
+
**[[8soi]], [[8sqz]] – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein<br />
 +
**[[8srm]] – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein – Cryo EM<br />
 +
**[[9c82]] – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein + PI3K – Cryo EM<br />
 +
**[[6qav]], [[6qau]], [[6qat]], [[6yid]] – hChk Ulk2 + inhibitor<br />
**[[4wzx]] – hChk Ulk3 MIT 2 domain + inhibitor<br />
**[[4wzx]] – hChk Ulk3 MIT 2 domain + inhibitor<br />
**[[6fdz]], [[6fdy]] – hChk Ulk3 + leukemia drug<br />
**[[6fdz]], [[6fdy]] – hChk Ulk3 + leukemia drug<br />
Line 553: Line 673:
**[[4pu3]], [[4pu4]] – SoChk Hipa + Hipb + DNA - ''Shewanella oneidensis''<br />
**[[4pu3]], [[4pu4]] – SoChk Hipa + Hipb + DNA - ''Shewanella oneidensis''<br />
**[[4pu5]] – SoChk Hipa + AMPPNP<br />
**[[4pu5]] – SoChk Hipa + AMPPNP<br />
 +
 +
*'''Chk Smg'''
 +
 +
**[[6l53]] – hChk Smg1 – Cryo EM <br />
 +
**[[7pw6]] – hChk Smg1 + inhibitor – Cryo EM <br />
 +
**[[7pw7]] – hChk Smg1 + Smg9 + inhibitor – Cryo EM <br />
 +
**[[7pw9]] – hChk Smg1 + Smg9 + AMPPNP + ATP – Cryo EM <br />
 +
**[[6l54]], [[6syt]] – hChk Smg1 + Smg8 + Smg9 – Cryo EM <br />
 +
**[[7pw4]], [[7pw5]] – hChk Smg1 + Smg8 + Smg9 + inhibitor – Cryo EM <br />
 +
**[[7pw8]] – hChk Smg1 + Smg8 + Smg9 + AMPPNP – Cryo EM <br />
 +
**[[6z3r]] – hChk Smg1 + Smg8 + Smg9 + regulator of nonsense transcripts – Cryo EM <br />
 +
**[[2hwy]] – hChk Smg5 PIN domain <br />
 +
**[[2hww]], [[2hwx]] – hChk Smg6 PIN domain (mutant)<br />
 +
**[[4um2]] – hChk Smg6 TPR domain <br />
 +
**[[1ya0]] – hChk Smg7 N terminal <br />
 +
 +
*'''Chk Vprbp or DCAF1'''
 +
 +
**[[4pxw]], [[8ood]] – hChk Vprbp WD repeat domain 1039-1401 (mutant) <br />
 +
**[[7sse]], [[7ufv]], [[8f8e]], [[8og5]], [[8og6]], [[8og7]], [[8og8]], [[8og9]], [[8oga]], [[8ogb]], [[8ogc]], [[8oo5]], [[8ood]] – hChk Vprbp WD repeat domain (mutant) + inhibitor<br />
 +
**[[5aja]] – hChk Vprbp WD repeat domain + VPX + SAMHD1<br />
*'''Other Chk'''
*'''Other Chk'''
Line 558: Line 699:
**[[1wak]] – hChk Sprk1 <br />
**[[1wak]] – hChk Sprk1 <br />
**[[3dak]] – hChk Osr1 kinase domain <br />
**[[3dak]] – hChk Osr1 kinase domain <br />
 +
**[[7okw]] – hChk Osr1 C-terminal <br />
**[[4aw2]] – hChk Mrckα kinase domain<br />
**[[4aw2]] – hChk Mrckα kinase domain<br />
-
**[[4pxw]] – hChk Vprbp WD repeat domain (mutant)<br />
+
**[[4pxw]], [[8ood]] – hChk Vprbp WD repeat domain (mutant)<br />
 +
**[[7v7c]] – hChk Vprbp in DDB1-VPRBP-VPR-UNG2 complex – Cryo EM<br />
 +
**[[7v7c]] – hChk Vprbp in DDB1-VPRBP-VPR-UNG2 complex – Cryo EM<br />
**[[1uf0]] – hChk Dcamkl1 DCX domain – NMR<br />
**[[1uf0]] – hChk Dcamkl1 DCX domain – NMR<br />
-
**[[6fdo]], [[6fdn]], [[6fdm]] – hChk Rio2 <br />
+
**[[1u5q]] – rChk Tao2 kinase domain <br />
-
**[[1u5q]], [[1u5r]] – rChk Tao2 kinase domain <br />
+
**[[2cos]] – mChk Lats2 – NMR<br />
**[[2cos]] – mChk Lats2 – NMR<br />
**[[1xte]], [[1xtn]], [[6edx]] – mChk Sgk3 PX domain <br />
**[[1xte]], [[1xtn]], [[6edx]] – mChk Sgk3 PX domain <br />
-
**[[4yom]] – mChk Sad <br />
+
**[[4yom]] – mChk Brsk2 <br />
-
**[[4ynz]] – mChk Sad N terminal domain <br />
+
**[[4ynz]] – mChk Brsk1 N terminal domain <br />
-
**[[5iri]] – mChk Sad residues 592-719<br />
+
**[[5iri]] – mChk Brsk1 residues 592-719<br />
-
**[[5oat]] – rfbChk – red flour beetle <br />
+
**[[5oat]], [[7mp8]] – rfbChk Pink1– red flour beetle <br />
 +
**[[7t3x]] – Chk Pink1 (mutant) – louse<br />
**[[4f0g]] – smChk Roco4 kinase domain – slime mold<br />
**[[4f0g]] – smChk Roco4 kinase domain – slime mold<br />
 +
**[[5tos]] – AtChk Bik1 <br />
**[[1q8z]], [[1zyc]] – yChk <br />
**[[1q8z]], [[1zyc]] – yChk <br />
**[[1how]], [[1zxe]], [[1zy4]] – yChk (mutant)<br />
**[[1how]], [[1zxe]], [[1zy4]] – yChk (mutant)<br />
Line 580: Line 725:
**[[6u69]] – CaChk Yck2 – ''Candida albicans''<br />
**[[6u69]] – CaChk Yck2 – ''Candida albicans''<br />
**[[6sl1]], [[6sl0]], [[6skz]], [[6sky]] – Chk Tel1 – ''Chaetonium thermophilum'' – Cryo EM<br />
**[[6sl1]], [[6sl0]], [[6skz]], [[6sky]] – Chk Tel1 – ''Chaetonium thermophilum'' – Cryo EM<br />
-
**[[6ra0]] – Chk Dkf1 – ''Chaenorhabditis elegans''<br />
+
**[[6ra0]] – CeChk Dkf1 – ''Chaenorhabditis elegans''<br /><br />
-
**[[5tos]] – AtChk Bik1 <br />
+
**[[7z6e]] – CeChk Mrck1 regulatory domain<br />
 +
**[[6tlb]] – Chk – ''Plasmodium falciparum''<br />
*Other Chk complexes
*Other Chk complexes
-
**[[1wbp]] – hChk Sprk1 + peptide<br />
+
**[[1wbp]], [[7dd1]] – hChk Sprk1 + peptide<br />
**[[3beg]] – hChk Srpk1 + splicing factor SF2<br />
**[[3beg]] – hChk Srpk1 + splicing factor SF2<br />
-
**[[3hdm]], [[3hdn]] – hChk Sgk1 (mutant) + inhibitor <br />
+
**[[3hdm]], [[3hdn]], [[7pue]] – hChk Sgk1 (mutant) + inhibitor <br />
**[[2r5t]] – hChk Sgk3 + AMPPNP <br />
**[[2r5t]] – hChk Sgk3 + AMPPNP <br />
-
**[[4yff]], [[4yfi]], [[6b5j]] – hChk Tnni3k + inhibitor <br />
+
**[[4yff]], [[4yfi]], [[6b5j]], [[7mgj]], [[7mgk]] – hChk Tnni3k + inhibitor <br />
-
**[[4otp]] – hChk Rio1 Rio domain + ADP <br />
+
-
**[[6hk6]] – hChk Rio2 + inhibitor <br />
+
**[[2v3s]] – hChk Osr1 + hChk Wnk4 peptide <br />
**[[2v3s]] – hChk Osr1 + hChk Wnk4 peptide <br />
**[[2vwi]] – hChk Osr1 kinase domain + ANP <br />
**[[2vwi]] – hChk Osr1 kinase domain + ANP <br />
-
**[[5jzj]] – hChk Dclk1 kinase domain + AMPPN <br />
+
**[[7que]], [[7quf]] – hChk Drak1 kinase domain + inhibitor<br />
-
**[[5jzn]] – hChk Dclk1 kinase domain + inhibitor <br />
+
**[[4crs]] – hChk N2 kinase domain + ATPγS<br />
**[[4crs]] – hChk N2 kinase domain + ATPγS<br />
**[[3tku]], [[4ual]], [[3qfv]], [[5ote]], [[5otf]] – hChk Mrckβ + inhibitor<br />
**[[3tku]], [[4ual]], [[3qfv]], [[5ote]], [[5otf]] – hChk Mrckβ + inhibitor<br />
Line 610: Line 753:
**[[5yh3]] – hChk Fam20C 141-578 + pseudokinase Fam20A<br />
**[[5yh3]] – hChk Fam20C 141-578 + pseudokinase Fam20A<br />
**[[2gcd]] – rChk Tao2 kinase domain + staurosporine<br />
**[[2gcd]] – rChk Tao2 kinase domain + staurosporine<br />
-
**[[5yj9]] – rfbChk Pink1 kinase domain + AMPPNP<br />
+
**[[1u5r]] – rChk Tao2 kinase domain + ATP<br />
 +
**[[5yj9]], [[7mp9]] – rfbChk Pink1 kinase domain + AMPPNP<br />
 +
**[[6bn1]] – DmChk Hippo SARAH domain + Shar-Pei<br />
**[[3hgk]] – Chk Pto + effector protein AVRPTOB – Currant tomato<br />
**[[3hgk]] – Chk Pto + effector protein AVRPTOB – Currant tomato<br />
 +
**[[3p86]], [[3ppz]] - AtChk Ctr1 + staurosporine<br />
**[[4f0f]] – smChk Roco4 kinase domain + APPCP <br />
**[[4f0f]] – smChk Roco4 kinase domain + APPCP <br />
**[[4f1m]], [[4f1o]] – smChk Roco4 kinase domain (mutant) + APPCP <br />
**[[4f1m]], [[4f1o]] – smChk Roco4 kinase domain (mutant) + APPCP <br />
-
**[[4f1t]] – smChk Roco4 kinase domain + inhibitor <br />
+
**[[4f1t]], [[4yzm]], [[4yzn]] – smChk Roco4 kinase domain + inhibitor <br />
**[[5fvm]] - Tor2 + LST8 - ''Kluyveromyces marxianus''<br />
**[[5fvm]] - Tor2 + LST8 - ''Kluyveromyces marxianus''<br />
**[[5kc2]] - yVps15 + Vps34 - Cryo EM<br />
**[[5kc2]] - yVps15 + Vps34 - Cryo EM<br />
Line 623: Line 769:
**[[4lqs]], [[4lqq]], [[4lqp]] – yChk Cbk1 residues 251-756 + Cbk1 activator Mob2<br />
**[[4lqs]], [[4lqq]], [[4lqp]] – yChk Cbk1 residues 251-756 + Cbk1 activator Mob2<br />
**[[6emk]] – yChk Tor2 + LST8 + TSC11 + AVO1 + AVO2 – Cryo EM<br />
**[[6emk]] – yChk Tor2 + LST8 + TSC11 + AVO1 + AVO2 – Cryo EM<br />
-
**[[6s8f]] – yChk Tel1 + ANP – Cryo EM<br />
+
**[[6s8f]] – yChk Tel1 + AMPPNP – Cryo EM<br />
**[[5yyz]] – yChk Mek1 FHA domain + Hop1<br />
**[[5yyz]] – yChk Mek1 FHA domain + Hop1<br />
-
**[[5x6o]] – yChk Mec1 + LCD1 – Cryo EM<br />
+
**[[5x6o]], [[6z3a]], [[7wzr]], [[7wzw]] – yChk Mec1 + LCD1 – Cryo EM<br />
-
**[[6bn1]] – DmChk Hippo sarah domain + Shar-Pei<br />
+
**[[6z2w]], [[6z2x]] – yChk Mec1 (mutant) + LCD1 – Cryo EM<br />
-
**[[3p86]], [[3ppz]] - AtChk Ctr1 + staurosporine<br />
+
**[[7kue]] – yChk Kin28 in TFIIK complex – Cryo EM<br />
**[[6u6a]] – CaChk Yck2 + inhibitor<br />
**[[6u6a]] – CaChk Yck2 + inhibitor<br />
-
**[[5fvm]] – Chk Tor2 + LST8 – ''Kluyveromyces maximanus''<br />
+
**[[5fvm]] – Chk Tor2 + LST8 – ''Kluyveromyces maximanus''<br
*Serine/threonine protein kinase Rad53 see [[Rad53]]
*Serine/threonine protein kinase Rad53 see [[Rad53]]
 +
 +
*Serine/threonine protein kinase Gsk3B see [[Glycogen synthase kinase 3]]
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of serine/threonine protein kinase

Updated on 23-July-2024

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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