7d8r
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7d8r is ON HOLD until Paper Publication Authors: Guo, M., Fang, P., Wang, J. Description: MITF HLHLZ structure Category: Unreleased Structures ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==MITF HLHLZ structure== | |
| - | + | <StructureSection load='7d8r' size='340' side='right'caption='[[7d8r]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7d8r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D8R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d8r OCA], [https://pdbe.org/7d8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d8r RCSB], [https://www.ebi.ac.uk/pdbsum/7d8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d8r ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Fang | + | == Disease == |
| - | [[Category: Wang | + | [https://www.uniprot.org/uniprot/MITF_HUMAN MITF_HUMAN] MITF-related melanoma and renal cell carcinoma predisposition syndrome;Clear cell renal carcinoma;Papillary renal cell carcinoma;Tietz syndrome;Waardenburg syndrome type 2;Ocular albinism with congenital sensorineural deafness. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MITF_HUMAN MITF_HUMAN] Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.<ref>PMID:10587587</ref> <ref>PMID:22647378</ref> [https://www.uniprot.org/uniprot/O66738_AQUAE O66738_AQUAE] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aquifex aeolicus VF5]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fang P]] | ||
| + | [[Category: Guo M]] | ||
| + | [[Category: Wang J]] | ||
Current revision
MITF HLHLZ structure
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