5yav

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Current revision (10:22, 27 March 2024) (edit) (undo)
 
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<StructureSection load='5yav' size='340' side='right'caption='[[5yav]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
<StructureSection load='5yav' size='340' side='right'caption='[[5yav]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5yav]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YAV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5yav]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YAV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8SF:1-phenyl-5-propan-2-ylsulfanyl-1,2,3,4-tetrazole'>8SF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.989&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5yav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yav OCA], [http://pdbe.org/5yav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yav RCSB], [http://www.ebi.ac.uk/pdbsum/5yav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yav ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8SF:1-phenyl-5-propan-2-ylsulfanyl-1,2,3,4-tetrazole'>8SF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yav OCA], [https://pdbe.org/5yav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yav RCSB], [https://www.ebi.ac.uk/pdbsum/5yav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yav ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
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[https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bing, X]]
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[[Category: Bing X]]
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[[Category: Danyan, C]]
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[[Category: Danyan C]]
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[[Category: Yanlian, L]]
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[[Category: Yanlian L]]
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[[Category: Oncoprotein]]
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[[Category: Pde6delta]]
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Current revision

Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction

PDB ID 5yav

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