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5yav
From Proteopedia
(Difference between revisions)
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<StructureSection load='5yav' size='340' side='right'caption='[[5yav]], [[Resolution|resolution]] 1.99Å' scene=''> | <StructureSection load='5yav' size='340' side='right'caption='[[5yav]], [[Resolution|resolution]] 1.99Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5yav]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAV OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5yav]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YAV FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8SF:1-phenyl-5-propan-2-ylsulfanyl-1,2,3,4-tetrazole'>8SF</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.989Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8SF:1-phenyl-5-propan-2-ylsulfanyl-1,2,3,4-tetrazole'>8SF</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yav OCA], [https://pdbe.org/5yav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yav RCSB], [https://www.ebi.ac.uk/pdbsum/5yav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yav ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bing | + | [[Category: Bing X]] |
| - | [[Category: Danyan | + | [[Category: Danyan C]] |
| - | [[Category: Yanlian | + | [[Category: Yanlian L]] |
| - | + | ||
| - | + | ||
Current revision
Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction
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