6jvq

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==Crystal structure of human MTH1 in complex with compound MI1025==
==Crystal structure of human MTH1 in complex with compound MI1025==
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<StructureSection load='6jvq' size='340' side='right'caption='[[6jvq]]' scene=''>
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<StructureSection load='6jvq' size='340' side='right'caption='[[6jvq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JVQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6jvq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JVQ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jvq OCA], [http://pdbe.org/6jvq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jvq RCSB], [http://www.ebi.ac.uk/pdbsum/6jvq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jvq ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.197&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CJF:N4-cyclopropyl-6-morpholin-4-yl-pyrimidine-2,4-diamine'>CJF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jvq OCA], [https://pdbe.org/6jvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jvq RCSB], [https://www.ebi.ac.uk/pdbsum/6jvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jvq ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
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==See Also==
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*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cheng YS]]
[[Category: Cheng YS]]
[[Category: Li YH]]
[[Category: Li YH]]
[[Category: Peng C]]
[[Category: Peng C]]

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Crystal structure of human MTH1 in complex with compound MI1025

PDB ID 6jvq

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