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5zhz

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Current revision (08:56, 22 November 2023) (edit) (undo)
 
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<StructureSection load='5zhz' size='340' side='right'caption='[[5zhz]], [[Resolution|resolution]] 1.18&Aring;' scene=''>
<StructureSection load='5zhz' size='340' side='right'caption='[[5zhz]], [[Resolution|resolution]] 1.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zhz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZHZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zhz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZHZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.18&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxyribonuclease_IV_(phage-T(4)-induced) Deoxyribonuclease IV (phage-T(4)-induced)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.2 3.1.21.2] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhz OCA], [http://pdbe.org/5zhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zhz RCSB], [http://www.ebi.ac.uk/pdbsum/5zhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhz OCA], [https://pdbe.org/5zhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zhz RCSB], [https://www.ebi.ac.uk/pdbsum/5zhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/END4_MYCTU END4_MYCTU]] Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.[HAMAP-Rule:MF_00152]
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[https://www.uniprot.org/uniprot/END4_MYCTU END4_MYCTU] Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.[HAMAP-Rule:MF_00152]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5zhz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5zhz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Apurinic/apyrimidinic endonuclease 3D structures|Apurinic/apyrimidinic endonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Li, S]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Rao, Z]]
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[[Category: Li S]]
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[[Category: Wang, H]]
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[[Category: Rao Z]]
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[[Category: Xu, Y]]
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[[Category: Wang H]]
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[[Category: Yan, M]]
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[[Category: Xu Y]]
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[[Category: Yang, H]]
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[[Category: Yan M]]
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[[Category: Zhang, W]]
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[[Category: Yang H]]
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[[Category: Zhou, W]]
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[[Category: Zhang W]]
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[[Category: Dna binding protein]]
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[[Category: Zhou W]]
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[[Category: Dna repair]]
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[[Category: Endonuclease iv]]
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[[Category: Tim fold]]
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Current revision

Crystal structure of the apurinic/apyrimidinic endonuclease IV from Mycobacterium tuberculosis

PDB ID 5zhz

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