1cxv

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[[Image:1cxv.gif|left|200px]]
 
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==STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)==
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The line below this paragraph, containing "STRUCTURE_1cxv", creates the "Structure Box" on the page.
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<StructureSection load='1cxv' size='340' side='right'caption='[[1cxv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cxv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CXV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CBP:2-{4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYL]-TETRAHYDRO-PYRAN-4-YL}-N-HYDROXY-ACETAMIDE'>CBP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1cxv| PDB=1cxv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cxv OCA], [https://pdbe.org/1cxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cxv RCSB], [https://www.ebi.ac.uk/pdbsum/1cxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cxv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP13_MOUSE MMP13_MOUSE] Degrades collagen type I.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/1cxv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cxv ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)'''
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==See Also==
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The matrix metalloproteinases are crucial in the physiological and pathological degradation of the mammalian extracellular matrix, including breast tumours, and osteoarthritic cartilage. These enzymes are classified according to their matrix substrate specificity. Collagenase-3 (MMP-13) is a member of this family and preferentially cleaves type II collagen, cartilage, fibronectin and aggrecan. Collagenase-3 is normally expressed in hypertrophic chondrocytes, periosteal cells, and osteoblasts during bone development. The structure of the catalytic domain of recombinant mouse collagenase-3, complexed to the hydroxamate inhibitor (RS-113456), is reported at 2.0 A resolution. Molecular replacement and weak phasing information from a single derivative determined the structure. Neither molecular replacement nor derivative methods had a sufficient radius of convergence to yield a refinable structure. The structure illuminates the atomic zinc ion interactions with functional groups in the active site, emphasizing zinc ligation and the very voluminous hydrophobic P1' group for the inhibitor potency. The structure provides insight into the specificity of this enzyme, facilitating design of specific inhibitors to target various diseases.
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[[Category: Large Structures]]
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==About this Structure==
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1CXV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CXV OCA].
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==Reference==
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Structure of recombinant mouse collagenase-3 (MMP-13)., Botos I, Meyer E, Swanson SM, Lemaitre V, Eeckhout Y, Meyer EF, J Mol Biol. 1999 Oct 1;292(4):837-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10525409 10525409]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Botos I]]
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[[Category: Botos, I.]]
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[[Category: Eeckhout Y]]
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[[Category: Eeckhout, Y.]]
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[[Category: Lemaitre V]]
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[[Category: Lemaitre, V.]]
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[[Category: Meyer E]]
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[[Category: Meyer, E.]]
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[[Category: Meyer EF]]
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[[Category: Meyer, E F.]]
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[[Category: Swanson SM]]
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[[Category: Swanson, S M.]]
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[[Category: Collagen degradation]]
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[[Category: Glycoprotein]]
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[[Category: Metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:13:33 2008''
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Current revision

STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)

PDB ID 1cxv

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