6azc
From Proteopedia
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==Crystal structure of Physcomitrella patens KAI2-like E S166A== | ==Crystal structure of Physcomitrella patens KAI2-like E S166A== | ||
| - | <StructureSection load='6azc' size='340' side='right'caption='[[6azc]]' scene=''> | + | <StructureSection load='6azc' size='340' side='right'caption='[[6azc]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZC OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6azc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Physcomitrium_patens Physcomitrium patens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AZC FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.0000122Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6azc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6azc OCA], [https://pdbe.org/6azc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6azc RCSB], [https://www.ebi.ac.uk/pdbsum/6azc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6azc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A9ST85_PHYPA A9ST85_PHYPA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | In plants, strigolactones are perceived by the dual receptor-hydrolase DWARF14 (D14). D14 belongs to the superfamily of alpha/beta hydrolases and is structurally similar to the karrikin receptor KARRIKIN INSENSITIVE 2 (KAI2). The moss Physcomitrella patens is an ideal model system for studying this receptor family, because it includes 11 highly related family members with unknown ligand specificity. We present the crystal structures of three Physcomitrella D14/KAI2-like proteins and describe a loop-based mechanism that leads to a permanent widening of the hydrophobic substrate gorge. We have identified protein clades that specifically perceive the karrikin KAR1 and the non-natural strigolactone isomer (-)-5-deoxystrigol in a highly stereoselective manner. | ||
| + | |||
| + | Structural Basis of Karrikin and Non-natural Strigolactone Perception in Physcomitrella patens.,Burger M, Mashiguchi K, Lee HJ, Nakano M, Takemoto K, Seto Y, Yamaguchi S, Chory J Cell Rep. 2019 Jan 22;26(4):855-865.e5. doi: 10.1016/j.celrep.2019.01.003. PMID:30673608<ref>PMID:30673608</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6azc" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Physcomitrium patens]] | ||
[[Category: Burger M]] | [[Category: Burger M]] | ||
[[Category: Chory J]] | [[Category: Chory J]] | ||
[[Category: Lee HJ]] | [[Category: Lee HJ]] | ||
Current revision
Crystal structure of Physcomitrella patens KAI2-like E S166A
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