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5rvx

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'''Unreleased structure'''
 
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The entry 5rvx is ON HOLD
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==PanDDA analysis group deposition -- Crystal Structure of DHTKD1 in complex with Z804566442==
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<StructureSection load='5rvx' size='340' side='right'caption='[[5rvx]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
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Authors: Bezerra, G.A., Foster, W.R., Bailey, H.J., Shrestha, L., Krojer, T., Brandao-Neto, J., Douangamath, A., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Yue, W.W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5rvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5RVX FirstGlance]. <br>
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Description: PanDDA analysis group deposition --Crystal Structure of DHTKD1 in complex with Z804566442
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.661&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B0Y:5-ethyl-~{N}-[(1-methylpyrazol-4-yl)methyl]thiophene-2-carboxamide'>B0Y</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
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[[Category: Foster, W.R]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rvx OCA], [https://pdbe.org/5rvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5rvx RCSB], [https://www.ebi.ac.uk/pdbsum/5rvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5rvx ProSAT]</span></td></tr>
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[[Category: Bailey, H.J]]
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</table>
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[[Category: Arrowsmith, C.H]]
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== Disease ==
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[[Category: Burgess-Brown, N]]
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[https://www.uniprot.org/uniprot/DHTK1_HUMAN DHTK1_HUMAN] 2-aminoadipic 2-oxoadipic aciduria;Autosomal dominant Charcot-Marie-Tooth disease type 2Q. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Brandao-Neto, J]]
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== Function ==
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[[Category: Shrestha, L]]
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[https://www.uniprot.org/uniprot/DHTK1_HUMAN DHTK1_HUMAN] The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
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[[Category: Bezerra, G.A]]
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__TOC__
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[[Category: Edwards, A]]
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</StructureSection>
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[[Category: Douangamath, A]]
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[[Category: Homo sapiens]]
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[[Category: Krojer, T]]
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[[Category: Large Structures]]
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[[Category: Yue, W.W]]
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[[Category: Arrowsmith CH]]
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[[Category: Von Delft, F]]
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[[Category: Bailey HJ]]
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[[Category: Bountra, C]]
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[[Category: Bezerra GA]]
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[[Category: Bountra C]]
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[[Category: Brandao-Neto J]]
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[[Category: Burgess-Brown N]]
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[[Category: Douangamath A]]
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[[Category: Edwards A]]
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[[Category: Foster WR]]
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[[Category: Krojer T]]
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[[Category: Shrestha L]]
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[[Category: Yue WW]]
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[[Category: Von Delft F]]

Current revision

PanDDA analysis group deposition -- Crystal Structure of DHTKD1 in complex with Z804566442

PDB ID 5rvx

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OCA

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