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6xcl
From Proteopedia
(Difference between revisions)
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==Crystal Structure of human telomeric DNA G-quadruplex in complex with a novel platinum(II) complex.== | ==Crystal Structure of human telomeric DNA G-quadruplex in complex with a novel platinum(II) complex.== | ||
| - | <StructureSection load='6xcl' size='340' side='right'caption='[[6xcl]]' scene=''> | + | <StructureSection load='6xcl' size='340' side='right'caption='[[6xcl]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCL OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6xcl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XCL FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=V4A:Platinum(II)+bis[3-(pyridin-2-yl)-[1,2,4]triazolo[4,3-a]pyridine]'>V4A</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xcl OCA], [https://pdbe.org/6xcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xcl RCSB], [https://www.ebi.ac.uk/pdbsum/6xcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xcl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Guanine quadruplex recognition has gained increasing attention, inspired by the growing awareness of the key roles played by these non-canonical nucleic acid architectures in cellular regulatory processes. We report here the solution and solid-state studies of a novel planar platinum(II) complex that is easily assembled from a simple ligand, and exhibits notable binding affinity for guanine quadruplex structures, while maintaining good selectivity for guanine quadruplex over duplex structures. A crystal structure of this ligand complexed with a telomeric quadruplex confirms double end-capping, with dimerization at the 5' interface. | ||
| + | |||
| + | Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.,Miron CE, van Staalduinen L, Rangaswamy AMM, Chen M, Liang Y, Jia Z, Mergny JL, Petitjean A Angew Chem Int Ed Engl. 2020 Oct 22. doi: 10.1002/anie.202012520. PMID:33090592<ref>PMID:33090592</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6xcl" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Jia Z]] | [[Category: Jia Z]] | ||
Current revision
Crystal Structure of human telomeric DNA G-quadruplex in complex with a novel platinum(II) complex.
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