4azm
From Proteopedia
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<StructureSection load='4azm' size='340' side='right'caption='[[4azm]], [[Resolution|resolution]] 2.75Å' scene=''> | <StructureSection load='4azm' size='340' side='right'caption='[[4azm]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[4azm]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4azm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AZM FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=T4B:((2-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC+ACID'>T4B</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=T4B:((2-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC+ACID'>T4B</scene></td></tr> | |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4azm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4azm OCA], [https://pdbe.org/4azm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4azm RCSB], [https://www.ebi.ac.uk/pdbsum/4azm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4azm ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Deutsch | + | [[Category: Deutsch D]] |
- | [[Category: Kaczocha | + | [[Category: Kaczocha M]] |
- | [[Category: Li | + | [[Category: Li H]] |
- | [[Category: Ojima | + | [[Category: Ojima I]] |
- | [[Category: Sanson | + | [[Category: Sanson B]] |
- | [[Category: Sun | + | [[Category: Sun J]] |
- | [[Category: Wang | + | [[Category: Wang T]] |
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Current revision
Human epidermal fatty acid-binding protein (FABP5) in complex with the inhibitor BMS-309413
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Categories: Homo sapiens | Large Structures | Deutsch D | Kaczocha M | Li H | Ojima I | Sanson B | Sun J | Wang T