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7atz

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'''Unreleased structure'''
 
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The entry 7atz is ON HOLD until Paper Publication
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==G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite==
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<StructureSection load='7atz' size='340' side='right'caption='[[7atz]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7atz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ATZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ATZ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7atz OCA], [https://pdbe.org/7atz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7atz RCSB], [https://www.ebi.ac.uk/pdbsum/7atz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7atz ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The KCNN4 gene encoding a potassium channel protein whose expression has been correlated with tumor progression was found to comprise a guanine-rich minisatellite region with the ability to form a putative G-quadruplex (G4). Given the suggested regulatory role of G4s in gene expression, G-quadruplex formation for the polymorphic first repeat of the minisatellite was studied by nuclear magnetic resonance spectroscopy. A stable G-quadruplex of a truncated mutant sequence was shown to represent one of several coexisting species of the wild-type sequence. The high-resolution structure features a noncanonical G4 with a broken G-column and a V-shaped loop. The presence of a 3'-flanking thymidine interacting with the lateral loop preceding the V loop seems to be critical for the formation of this G4 topology. On the contrary, an additional 5'-flanking residue disfavored but still allowed folding into the V-loop structure. The latter may therefore serve as a putative therapeutic target in strategies for G4-based modulation of KCNN4 expression.
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Authors:
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First Tandem Repeat of a Potassium Channel KCNN4 Minisatellite Folds into a V-Loop G-Quadruplex Structure.,Vianney YM, Weisz K Biochemistry. 2021 Apr 12. doi: 10.1021/acs.biochem.1c00043. PMID:33844501<ref>PMID:33844501</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 7atz" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Vianney, Y M]]
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[[Category: Weisz, K]]
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[[Category: Dna]]
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[[Category: G-quadruplex]]
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[[Category: V-loop]]

Current revision

G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite

PDB ID 7atz

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