6ek4

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Current revision (07:31, 1 May 2024) (edit) (undo)
 
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<StructureSection load='6ek4' size='340' side='right'caption='[[6ek4]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='6ek4' size='340' side='right'caption='[[6ek4]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ek4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EK4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6EK4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ek4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Photorhabdus_luminescens Photorhabdus luminescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EK4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ek4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ek4 OCA], [http://pdbe.org/6ek4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ek4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ek4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ek4 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ek4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ek4 OCA], [https://pdbe.org/6ek4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ek4 RCSB], [https://www.ebi.ac.uk/pdbsum/6ek4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ek4 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A1B8YJW8_9GAMM A0A1B8YJW8_9GAMM]
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Pore-forming toxins (PFT) are virulence factors that transform from soluble to membrane-bound states. The Yersinia YaxAB system represents a family of binary alpha-PFTs with orthologues in human, insect, and plant pathogens, with unknown structures. YaxAB was shown to be cytotoxic and likely involved in pathogenesis, though the molecular basis for its two-component lytic mechanism remains elusive. Here, we present crystal structures of YaxA and YaxB, together with a cryo-electron microscopy map of the YaxAB complex. Our structures reveal a pore predominantly composed of decamers of YaxA-YaxB heterodimers. Both subunits bear membrane-active moieties, but only YaxA is capable of binding to membranes by itself. YaxB can subsequently be recruited to membrane-associated YaxA and induced to present its lytic transmembrane helices. Pore formation can progress by further oligomerization of YaxA-YaxB dimers. Our results allow for a comparison between pore assemblies belonging to the wider ClyA-like family of alpha-PFTs, highlighting diverse pore architectures.
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Structure and mechanism of the two-component alpha-helical pore-forming toxin YaxAB.,Brauning B, Bertosin E, Praetorius F, Ihling C, Schatt A, Adler A, Richter K, Sinz A, Dietz H, Groll M Nat Commun. 2018 May 4;9(1):1806. doi: 10.1038/s41467-018-04139-2. PMID:29728606<ref>PMID:29728606</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6ek4" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Braeuning, B]]
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[[Category: Photorhabdus luminescens]]
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[[Category: Groll, M]]
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[[Category: Braeuning B]]
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[[Category: Adventitious membrane protein]]
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[[Category: Groll M]]
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[[Category: Alpha-helical]]
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[[Category: Membrane protein]]
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[[Category: Pathogen]]
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[[Category: Pore forming toxin]]
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Current revision

PaxB from Photorhabdus luminescens

PDB ID 6ek4

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OCA

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