6xkj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of CARD8-CARD filament== | |
| + | <StructureSection load='6xkj' size='340' side='right'caption='[[6xkj]], [[Resolution|resolution]] 3.54Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6xkj]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XKJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.54Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xkj OCA], [https://pdbe.org/6xkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xkj RCSB], [https://www.ebi.ac.uk/pdbsum/6xkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xkj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CARD8_HUMAN CARD8_HUMAN] Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases. | ||
| - | + | ==See Also== | |
| - | + | *[[Caspase 3D structures|Caspase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: David L]] |
| - | [[Category: | + | [[Category: Fontana P]] |
| - | [[Category: | + | [[Category: Fu T]] |
| - | [[Category: | + | [[Category: Hollingsworth LR]] |
| - | [[Category: Wu | + | [[Category: Li Y]] |
| + | [[Category: Sharif H]] | ||
| + | [[Category: Wu H]] | ||
Current revision
Cryo-EM structure of CARD8-CARD filament
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Categories: Homo sapiens | Large Structures | David L | Fontana P | Fu T | Hollingsworth LR | Li Y | Sharif H | Wu H
