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1d32

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[[Image:1d32.jpg|left|200px]]
 
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==DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1d32", creates the "Structure Box" on the page.
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<StructureSection load='1d32' size='340' side='right'caption='[[1d32]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1d32]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D32 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIT:DITERCALINIUM'>DIT</scene></td></tr>
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{{STRUCTURE_1d32| PDB=1d32 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d32 OCA], [https://pdbe.org/1d32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d32 RCSB], [https://www.ebi.ac.uk/pdbsum/1d32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d32 ProSAT]</span></td></tr>
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</table>
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'''DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Chen S-L]]
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Ditercalinium is a synthetic anticancer drug that binds to DNA by bis-intercalation and activates DNA repair processes. In prokaryotes, noncovalent DNA-ditercalinium complexes are incorrectly recognized by the uvrABC repair system as covalent lesions on DNA. In eukaryotes, mitochondrial DNA is degraded by excess and futile DNA repair. Using x-ray crystallography, we have determined, to 1.7 A resolution, the three-dimensional structure of a complex of ditercalinium bound to the double-stranded DNA fragment [d(CGCG)]2. The DNA in the complex with ditercalinium is kinked (by 15 degrees) and severely unwound (by 36 degrees) with exceptionally wide major and minor grooves. Recognition of the DNA-ditercalinium complex by uvrABC in prokaryotes, and by mitochondrial DNA repair systems in eukaryotes, might be related to drug-induced distortion of the DNA helix.
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[[Category: Egli M]]
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[[Category: Gao Q]]
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==About this Structure==
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[[Category: Quigley GJ]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D32 OCA].
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[[Category: Rabinovich D]]
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[[Category: Rich A]]
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==Reference==
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[[Category: Williams LD]]
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Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex., Gao Q, Williams LD, Egli M, Rabinovich D, Chen SL, Quigley GJ, Rich A, Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2422-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2006181 2006181]
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[[Category: Chen, S L.]]
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[[Category: Egli, M.]]
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[[Category: Gao, Q.]]
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[[Category: Quigley, G J.]]
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[[Category: Rabinovich, D.]]
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[[Category: Rich, A.]]
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[[Category: Williams, L D.]]
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[[Category: Complexed with drug]]
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[[Category: Double helix]]
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[[Category: Right handed dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:23:48 2008''
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Current revision

DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX

PDB ID 1d32

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