6mxq

<StructureSection load='6mxq' size='340' side='right'caption='[[6mxq]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[6mxq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MXQ FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxq OCA], [http://pdbe.org/6mxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mxq RCSB], [http://www.ebi.ac.uk/pdbsum/6mxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxq ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Specialized translation initiation is a novel form of regulation of protein synthesis, whereby RNA structures within the 5'-UTR regulate translation rates of specific mRNAs. Similar to internal ribosome entry sites (IRESs), specialized translation initiation requires the recruitment of eukaryotic initiation factor 3 (eIF3), but also requires cap recognition by eIF3d, a new 5'-m(7)GTP recognizing protein. How these RNA structures mediate eIF3 recruitment to affect translation of specific mRNAs remains unclear. Here, we report the nuclear magnetic resonance (NMR) structure of a stem-loop within the c-JUN 5' UTR recognized by eIF3 and essential for specialized translation initiation of this well-known oncogene. The structure exhibits similarity to eIF3 recognizing motifs found in hepatitis C virus (HCV)-like IRESs, suggesting mechanistic similarities. This work establishes the RNA structural features involved in c-JUN specialized translation initiation and provides a basis to search for small molecule inhibitors of aberrant expression of the proto-oncogenic c-JUN.

Structure of the RNA Specialized Translation Initiation Element that Recruits eIF3 to the 5'-UTR of c-Jun.,Walker MJ, Shortridge MD, Albin DD, Cominsky LY, Varani G J Mol Biol. 2020 Mar 27;432(7):1841-1855. doi: 10.1016/j.jmb.2020.01.001. Epub, 2020 Jan 14. PMID:31953146<ref>PMID:31953146</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Shortridge, M]]

[[Category: Varani, G]]

[[Category: Walker, M]]

[[Category: Specialized translation initiation]]