1cnt

<table><tr><td colspan='2'>[[1cnt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CNT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1CNT FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HUMAN CNTF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1cnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cnt OCA], [http://pdbe.org/1cnt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cnt RCSB], [http://www.ebi.ac.uk/pdbsum/1cnt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cnt ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CNTF_HUMAN CNTF_HUMAN]] CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

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== Publication Abstract from PubMed ==

Ciliary neurotrophic factor (CNTF) promotes the survival and differentiation of developing motor neurons and is a potential therapeutic for treating neurodegeneration and nerve injury. The crystal structure of human CNTF has been determined at 2.4 A resolution using multi-wavelength anomalous diffraction (MAD) phasing from a single Yb3+ ions. The structure reveals that CNTF is dimeric, with a novel anti-parallel arrangement of the subunits, not previously observed for other cytokines. Each subunit adopts a double crossover four-helix bundle fold, in which two helices contribute to the dimer interface, whilst two different helices show pronounced kinks. Analysis of the electrostatic surface of CNTF identified residues within these kinked helices that may contact the CNTF receptor-alpha. Solution experiments show that CNTF dimerizes at concentrations &gt; 40 microM. Such dimers are likely to be relevant to the storage of CNTF in the peripheral nerve given the high concentrations present in this tissue. However, it is unlikely that they play a role in engaging the three distinct receptor subunits that comprise the CNTF receptor, given the low concentration of extracellular CNTF and its high potency.

Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing.,McDonald NQ, Panayotatos N, Hendrickson WA EMBO J. 1995 Jun 15;14(12):2689-99. PMID:7796798<ref>PMID:7796798</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1cnt" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Human]]

[[Category: Hendrickson, W A]]

[[Category: Mcdonald, N Q]]

[[Category: Panayotatos, N]]

[[Category: Neurotrophic factor]]