1zc5

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(New page: 200px<br /> <applet load="1zc5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zc5" /> '''Structure of the RNA signal essential for t...)
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[[Image:1zc5.gif|left|200px]]<br />
 
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<applet load="1zc5" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1zc5" />
 
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'''Structure of the RNA signal essential for translational frameshifting in HIV-1'''<br />
 
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==Overview==
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==Structure of the RNA signal essential for translational frameshifting in HIV-1==
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Many pathogenic viruses use a programmed -1 translational frameshifting, mechanism to regulate synthesis of their structural and enzymatic, proteins. Frameshifting is vital for viral replication. A slippery, sequence bound at the ribosomal A and P sites as well as a downstream, stimulatory RNA structure are essential for frameshifting. Conflicting, data have been reported concerning the structure of the downstream RNA, signal in human immunodeficiency virus type 1 (HIV-1). Here, the solution, structure of the HIV-1 frameshifting RNA signal was solved by, heteronuclear NMR spectroscopy. This structure reveals a long hairpin fold, with an internal three-nucleotide bulge. The internal loop introduces a, bend between the lower and upper helical regions, a structural feature, often seen in frameshifting pseudoknots. The NMR structure correlates with, chemical probing data. The upper stem rich in conserved G-C Watson-Crick, base-pairs is highly stable, whereas the bulge region and the lower stem, are more flexible.
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<StructureSection load='1zc5' size='340' side='right'caption='[[1zc5]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zc5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZC5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zc5 OCA], [https://pdbe.org/1zc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zc5 RCSB], [https://www.ebi.ac.uk/pdbsum/1zc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zc5 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Many pathogenic viruses use a programmed -1 translational frameshifting mechanism to regulate synthesis of their structural and enzymatic proteins. Frameshifting is vital for viral replication. A slippery sequence bound at the ribosomal A and P sites as well as a downstream stimulatory RNA structure are essential for frameshifting. Conflicting data have been reported concerning the structure of the downstream RNA signal in human immunodeficiency virus type 1 (HIV-1). Here, the solution structure of the HIV-1 frameshifting RNA signal was solved by heteronuclear NMR spectroscopy. This structure reveals a long hairpin fold with an internal three-nucleotide bulge. The internal loop introduces a bend between the lower and upper helical regions, a structural feature often seen in frameshifting pseudoknots. The NMR structure correlates with chemical probing data. The upper stem rich in conserved G-C Watson-Crick base-pairs is highly stable, whereas the bulge region and the lower stem are more flexible.
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==About this Structure==
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Structure of the RNA signal essential for translational frameshifting in HIV-1.,Gaudin C, Mazauric MH, Traikia M, Guittet E, Yoshizawa S, Fourmy D J Mol Biol. 2005 Jun 24;349(5):1024-35. PMID:15907937<ref>PMID:15907937</ref>
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1ZC5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZC5 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of the RNA signal essential for translational frameshifting in HIV-1., Gaudin C, Mazauric MH, Traikia M, Guittet E, Yoshizawa S, Fourmy D, J Mol Biol. 2005 Jun 24;349(5):1024-35. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15907937 15907937]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 1zc5" style="background-color:#fffaf0;"></div>
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[[Category: Fourmy, D.]]
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== References ==
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[[Category: Gaudin, C.]]
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<references/>
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[[Category: Guittet, E.]]
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__TOC__
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[[Category: Mazauric, M.H.]]
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</StructureSection>
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[[Category: Traikia, M.]]
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[[Category: Large Structures]]
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[[Category: Yoshizawa, S.]]
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[[Category: Fourmy D]]
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[[Category: rna bulged helix]]
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[[Category: Gaudin C]]
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[[Category: Guittet E]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov 8 14:38:24 2007''
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[[Category: Mazauric MH]]
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[[Category: Traikia M]]
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[[Category: Yoshizawa S]]

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Structure of the RNA signal essential for translational frameshifting in HIV-1

PDB ID 1zc5

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