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| <StructureSection load='1i81' size='340' side='right'caption='[[1i81]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='1i81' size='340' side='right'caption='[[1i81]], [[Resolution|resolution]] 2.00Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
- | <table><tr><td colspan='2'>[[1i81]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"methanobacterium_thermoautotrophicus"_(sic)_zeikus_and_wolfe_1972 "methanobacterium thermoautotrophicus" (sic) zeikus and wolfe 1972]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I81 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1I81 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1i81]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I81 FirstGlance]. <br> |
- | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d3b|1d3b]], [[1b34|1b34]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
- | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT0649 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=145262 "Methanobacterium thermoautotrophicus" (sic) Zeikus and Wolfe 1972])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i81 OCA], [https://pdbe.org/1i81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i81 RCSB], [https://www.ebi.ac.uk/pdbsum/1i81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i81 ProSAT]</span></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1i81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i81 OCA], [http://pdbe.org/1i81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i81 RCSB], [http://www.ebi.ac.uk/pdbsum/1i81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i81 ProSAT]</span></td></tr> | + | |
| </table> | | </table> |
| + | == Function == |
| + | [https://www.uniprot.org/uniprot/RUXX_METTH RUXX_METTH] |
| == Evolutionary Conservation == | | == Evolutionary Conservation == |
| [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| </StructureSection> | | </StructureSection> |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
- | [[Category: Collins, B M]] | + | [[Category: Methanothermobacter thermautotrophicus]] |
- | [[Category: Curmi, P M.G]] | + | [[Category: Collins BM]] |
- | [[Category: Dawes, I W]] | + | [[Category: Curmi PMG]] |
- | [[Category: Harrop, S J]] | + | [[Category: Dawes IW]] |
- | [[Category: Kornfeld, G D]] | + | [[Category: Harrop SJ]] |
- | [[Category: Mabbutt, B C]] | + | [[Category: Kornfeld GD]] |
- | [[Category: Curved anti-parallel beta sheet]] | + | [[Category: Mabbutt BC]] |
- | [[Category: Structural genomic]]
| + | |
| Structural highlights
Function
RUXX_METTH
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The Sm/Lsm proteins associate with small nuclear RNA to form the core of small nuclear ribonucleoproteins, required for processes as diverse as pre-mRNA splicing, mRNA degradation and telomere formation. The Lsm proteins from archaea are likely to represent the ancestral Sm/Lsm domain. Here, we present the crystal structure of the Lsm alpha protein from the thermophilic archaeon Methanobacterium thermoautotrophicum at 2.0 A resolution. The Lsm alpha protein crystallizes as a heptameric ring comprised of seven identical subunits interacting via beta-strand pairing and hydrophobic interactions. The heptamer can be viewed as a propeller-like structure in which each blade consists of a seven-stranded antiparallel beta-sheet formed from neighbouring subunits. There are seven slots on the inner surface of the heptamer ring, each of which is lined by Asp, Asn and Arg residues that are highly conserved in the Sm/Lsm sequences. These conserved slots are likely to form the RNA-binding site. In archaea, the gene encoding Lsm alpha is located next to the L37e ribosomal protein gene in a putative operon, suggesting a role for the Lsm alpha complex in ribosome function or biogenesis.
Crystal structure of a heptameric Sm-like protein complex from archaea: implications for the structure and evolution of snRNPs.,Collins BM, Harrop SJ, Kornfeld GD, Dawes IW, Curmi PM, Mabbutt BC J Mol Biol. 2001 Jun 15;309(4):915-23. PMID:11399068[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Collins BM, Harrop SJ, Kornfeld GD, Dawes IW, Curmi PM, Mabbutt BC. Crystal structure of a heptameric Sm-like protein complex from archaea: implications for the structure and evolution of snRNPs. J Mol Biol. 2001 Jun 15;309(4):915-23. PMID:11399068 doi:10.1006/jmbi.2001.4693
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