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7dhg

From Proteopedia

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m (Protected "7dhg" [edit=sysop:move=sysop])
Current revision (16:33, 29 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7dhg is ON HOLD
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==Crystal structure of SARS-CoV-2 Orf9b complex with human TOM70==
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<StructureSection load='7dhg' size='340' side='right'caption='[[7dhg]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Gao, X., Cui, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7dhg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DHG FirstGlance]. <br>
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Description: Crystal structure of the orf9b complex with TOM70
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dhg OCA], [https://pdbe.org/7dhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dhg RCSB], [https://www.ebi.ac.uk/pdbsum/7dhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dhg ProSAT]</span></td></tr>
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[[Category: Gao, X]]
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</table>
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[[Category: Cui, S]]
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== Function ==
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[https://www.uniprot.org/uniprot/TOM70_HUMAN TOM70_HUMAN] Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812).<ref>PMID:12526792</ref> <ref>PMID:20628368</ref> <ref>PMID:25609812</ref> <ref>PMID:32728199</ref> <ref>PMID:35025629</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Severe acute respiratory syndrome coronavirus 2]]
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[[Category: Cui S]]
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[[Category: Gao X]]
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[[Category: Olieric V]]
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[[Category: Qin B]]
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[[Category: Wang M]]
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[[Category: Zhu K]]

Current revision

Crystal structure of SARS-CoV-2 Orf9b complex with human TOM70

PDB ID 7dhg

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OCA

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