7kqg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses== | |
| + | <StructureSection load='7kqg' size='340' side='right'caption='[[7kqg]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7kqg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Florida/4/2006) Influenza B virus (B/Florida/4/2006)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KQG FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kqg OCA], [https://pdbe.org/7kqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kqg RCSB], [https://www.ebi.ac.uk/pdbsum/7kqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kqg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We describe cross-reactive human antibodies recognizing influenza B viruses spanning nearly 80 years of antigenic drift. Structures show that they engage the receptor-binding site (RBS) of the viral hemagglutinin with strong similarities to their influenza A counterparts, despite structural differences between the RBS of influenza A and B. Our data show that these antibodies readily cross-react with both influenza B Victoria and Yamagata lineages. We also note that all antibodies are encoded by IGHV3-9/IGK1-33. Future research will provide insight into the prevalence of these antibodies in the human population. | ||
| - | + | Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses.,Bajic G, Harrison SC ACS Infect Dis. 2021 Jan 8;7(1):1-5. doi: 10.1021/acsinfecdis.0c00726. Epub 2020 , Dec 4. PMID:33274930<ref>PMID:33274930</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 7kqg" style="background-color:#fffaf0;"></div> |
| - | [[Category: Bajic | + | |
| + | ==See Also== | ||
| + | *[[Antibody 3D structures|Antibody 3D structures]] | ||
| + | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bajic G]] | ||
| + | [[Category: Harrison SC]] | ||
Current revision
Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses
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