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7keu

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====
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==Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer==
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<StructureSection load='7keu' size='340' side='right'caption='[[7keu]]' scene=''>
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<StructureSection load='7keu' size='340' side='right'caption='[[7keu]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7keu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KEU FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7keu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7keu OCA], [http://pdbe.org/7keu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7keu RCSB], [http://www.ebi.ac.uk/pdbsum/7keu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7keu ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7keu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7keu OCA], [https://pdbe.org/7keu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7keu RCSB], [https://www.ebi.ac.uk/pdbsum/7keu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7keu ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
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==See Also==
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*[[Caspase 3D structures|Caspase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: David L]]
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[[Category: Hollingsworth LR]]
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[[Category: Li Y]]
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[[Category: Ruan J]]
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[[Category: Wu H]]

Current revision

Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer

PDB ID 7keu

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