1kzq

From Proteopedia

(Difference between revisions)

Current revision

crystal structure of a parasite protein

Structural highlights

1kzq is a 2 chain structure with sequence from Toxoplasma gondii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.7Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

P30_TOXGO

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. The 1.7 A structure of the immunodominant SAG1 antigen reveals a homodimeric configuration in which the dimeric interface is mediated by an extended beta-sheet that forms a deep groove lined with positively charged amino acids. This basic groove seems to be conserved among SRS proteins and potentially serves as a sulfated proteoglycan-binding site on target cell surfaces, thus rationalizing the promiscuous attachment properties of Toxoplasma to a broad range of host cell types.

Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily.,He XL, Grigg ME, Boothroyd JC, Garcia KC Nat Struct Biol. 2002 Aug;9(8):606-11. PMID:12091874^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ He XL, Grigg ME, Boothroyd JC, Garcia KC. Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily. Nat Struct Biol. 2002 Aug;9(8):606-11. PMID:12091874 doi:10.1038/nsb819

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kzq"

@@ Line 3: / Line 3: @@
 <StructureSection load='1kzq' size='340' side='right'caption='[[1kzq]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1kzq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1KZQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1kzq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KZQ FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SAG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1kzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kzq OCA], [http://pdbe.org/1kzq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kzq RCSB], [http://www.ebi.ac.uk/pdbsum/1kzq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kzq ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kzq OCA], [https://pdbe.org/1kzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kzq RCSB], [https://www.ebi.ac.uk/pdbsum/1kzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kzq ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/P30_TOXGO P30_TOXGO]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 12: / Line 14: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/1kzq_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 31: / Line 33: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Toxgo]]
-[[Category: Boothroyd, J C]]
-[[Category: Garcia, K C]]
-[[Category: Grigg, M E]]
-[[Category: He, X]]
-[[Category: Immune system]]
-[[Category: Mad]]
-[[Category: Major surface antigen]]
-[[Category: Parasite invasion]]
-[[Category: Sag1]]
 [[Category: Toxoplasma gondii]]
+[[Category: Boothroyd JC]]
+[[Category: Garcia KC]]
+[[Category: Grigg ME]]
+[[Category: He X]]

1kzq

From Proteopedia

Current revision

crystal structure of a parasite protein

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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