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Titin

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As seen in the image (Z1Z2 / Telethonin complex), the major force enduring component of this complex is an elaborate intermolecular hydrogen bonding network formed across <scene name='2a38/Test/2'>β-strand</scene> among telethonin and Z1Z2 domains, and not intramolecularly among termini β-strands of individual Z1 or Z2 domains. This shift to a stronger force enduring interface reduces the possibility of unraveling the individual Ig-domains, thus stabilizing the complex. This demonstrates how <scene name='2a38/Test/2'>β-strand</scene> cross-linking via [http://en.wikipedia.org/wiki/Hydrogen_bonds hydrogen bonds] serves as an important mechanism. It functions as a molecular adhesive, increasing the ability of protein complexes to resist against mechanical stress.
As seen in the image (Z1Z2 / Telethonin complex), the major force enduring component of this complex is an elaborate intermolecular hydrogen bonding network formed across <scene name='2a38/Test/2'>β-strand</scene> among telethonin and Z1Z2 domains, and not intramolecularly among termini β-strands of individual Z1 or Z2 domains. This shift to a stronger force enduring interface reduces the possibility of unraveling the individual Ig-domains, thus stabilizing the complex. This demonstrates how <scene name='2a38/Test/2'>β-strand</scene> cross-linking via [http://en.wikipedia.org/wiki/Hydrogen_bonds hydrogen bonds] serves as an important mechanism. It functions as a molecular adhesive, increasing the ability of protein complexes to resist against mechanical stress.
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== 3D Structures of Titin ==
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==Disease==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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See [[Titin related diseases]].
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== 3D Structures of Titin ==
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[[2a38]], [[6fwx]], [[6sdb]] - hTTN residues 1-194 - human<br />
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[[Titin 3D structures]]
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[[2f8v]], [[1ya5]] - hTTN residues 1-196+telethonin<br />
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[[6dl4]] – hTTN residues 1821-1931 - NMR<br />
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[[1g1c]] - hTTN residues 2027-2125<br />
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[[5jdd]], [[5jde]] – hTTN I9-I11 residues 2795-3053<br />
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[[4qeg]], [[5jdj]] - hTTN I10 residues 2880-2967<br />
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[[1tit]], [[1tiu]]- hTTN I27 residues 5253-5341 – NMR<br />
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[[5joe]] - hTTN I81 residues 9582-9671<br />
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[[2rq8]] – hTTN residues 12677-12765 (mutant) – NMR<br />
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[[1waa]] - hTTN residues 12801-12889<br />
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[[4o00]] - hTTN residues 14217-14319<br />
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[[1bpv]] – hTTN A71 residues 14859-14961 – NMR<br />
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[[3lpw]] – hTTN A77-A78 residues 22877-23070<br />
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[[5bs0]] – hTTN residues 24337-24345 + TCR<br />
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[[2j8h]], [[2j8o]], [[2ill]] – hTTN residues 24430-24623<br />
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[[1tki]] – hTTN serine kinase fragment residues 24748-25068<br />
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[[2bk8]] – hTTN residues 25073-25166<br />
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[[1nct]], [[1ncu]] – hTTN M5 residues 26059-26155 – NMR<br />
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[[1tnm]], [[1tnn]] – hTTN M5 residues 26059-26155<br />
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[[3lcy]] – hTTN A164-A165 residues 31456-31649<br />
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[[2nzi]] – hTTN residues 31854-32155<br />
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[[4jnw]] - hTTN residues 32172-32492<br />
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[[6hci]] - hTTN M3 residues 32712-32816<br />
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[[3qp3]], [[6h4l]] – hTTN M4 residues 33294-33395<br />
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[[3puc]] – hTTN M7 residues 33774-33871<br />
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[[2y9r]], [[3q5o]] – hTTN M10 residues 34252-34350<br />
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[[2wp3]], [[2wwm]], [[3knb]] – hTTN M10 residues 34252-34350 +obscurin-like protein 1 fragment <br />
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[[2wwk]] - hTTN M10 residues 34252-34350 +obscurin-like protein 1 fragment (mutant) <br />
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[[4c4k]], [[4uow]] - hTTN M10 residues 34252-34350 +obscurin IG domain<br />
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[[2rik]] – rTTN I67-I69 – rabbit<br />
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[[2rjm]] - rTTN I67-I69 (mutant)<br />
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[[3b43]] - rTTN I65-I70<br />
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[[1h8b]] – rTTN residues 648-698 + hα Actinin 2 EF hands 3&4<br />
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[[6i0y]] – TTN I27 residues 14318-14406 in 50S ribosome – ''Escherichia coli'' – Cryo EM<br />
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==Additional Resources==
==Additional Resources==
See: [[Titin Structure & Function]] for additional information <br />
See: [[Titin Structure & Function]] for additional information <br />

Current revision

Human titin dimer residues 1-196 (grey and pale green) complex with telethonin (dark green) and sulfate, 1ya5

Drag the structure with the mouse to rotate


References


Created with the participation of Anton Schmidt, Wolfgang Hermann.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner, Jaime Prilusky

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