7cy8

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Current revision (16:20, 29 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7cy8 is ON HOLD until Paper Publication
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==Crystal Structure of CMD1 in complex with 5mC-DNA and vitamin C==
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<StructureSection load='7cy8' size='340' side='right'caption='[[7cy8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7cy8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii], [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CY8 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=ASC:ASCORBIC+ACID'>ASC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cy8 OCA], [https://pdbe.org/7cy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cy8 RCSB], [https://www.ebi.ac.uk/pdbsum/7cy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cy8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/CMD1_CHLRE CMD1_CHLRE] Dioxygenase that catalyzes DNA modification by mediating the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-glyceryl-methylcytosine (5gmC) (PubMed:31043749, PubMed:33531488). Catalyzes the conjugation of a glyceryl moiety from L-ascorbate (vitamin C) to the methyl group of 5mC through a carbon-carbon bond (PubMed:31043749, PubMed:33531488). 5gmC DNA modification may be required during photosynthesis as an epigenetic mark that couteracts DNA methylation (PubMed:31043749).<ref>PMID:31043749</ref> <ref>PMID:33531488</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chlamydomonas reinhardtii]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Ding J]]
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[[Category: Li W]]
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[[Category: Sun M]]
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[[Category: Zhang T]]

Current revision

Crystal Structure of CMD1 in complex with 5mC-DNA and vitamin C

PDB ID 7cy8

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