1nee

From Proteopedia

(Difference between revisions)

Current revision

Structure of archaeal translation factor aIF2beta from Methanobacterium thermoautrophicum

Structural highlights

1nee is a 1 chain structure with sequence from Methanothermobacter thermautotrophicus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IF2B_METTH eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

aIF2 beta is the archaeal homolog of eIF2 beta, a member of the eIF2 heterotrimeric complex, implicated in the delivery of Met-tRNA(i)(Met) to the 40S ribosomal subunit. We have determined the solution structure of the intact beta-subunit of aIF2 from Methanobacterium thermoautotrophicum. aIF2 beta is composed of an unfolded N terminus, a mixed alpha/beta core domain and a C-terminal zinc finger. NMR data shows the two folded domains display restricted mobility with respect to each other. Analysis of the aIF2 gamma structure docked to tRNA allowed the identification of a putative binding site for the beta-subunit in the ternary translation complex. Based on structural similarity and biochemical data, a role for the different secondary structure elements is suggested.

Structure of the archaeal translation initiation factor aIF2 beta from Methanobacterium thermoautotrophicum: implications for translation initiation.,Gutierrez P, Osborne MJ, Siddiqui N, Trempe JF, Arrowsmith C, Gehring K Protein Sci. 2004 Mar;13(3):659-67. PMID:14978306^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Gutierrez P, Osborne MJ, Siddiqui N, Trempe JF, Arrowsmith C, Gehring K. Structure of the archaeal translation initiation factor aIF2 beta from Methanobacterium thermoautotrophicum: implications for translation initiation. Protein Sci. 2004 Mar;13(3):659-67. PMID:14978306 doi:http://dx.doi.org/10.1110/ps.03506604

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nee"

@@ Line 1: / Line 1: @@
 ==Structure of archaeal translation factor aIF2beta from Methanobacterium thermoautrophicum==
-<StructureSection load='1nee' size='340' side='right'caption='[[1nee]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='1nee' size='340' side='right'caption='[[1nee]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1nee]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"methanobacterium_thermoautotrophicus"_(sic)_zeikus_and_wolfe_1972 "methanobacterium thermoautotrophicus" (sic) zeikus and wolfe 1972]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1NEE FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1nee]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NEE FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTH1769 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=145262 "Methanobacterium thermoautotrophicus" (sic) Zeikus and Wolfe 1972])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1nee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nee OCA], [http://pdbe.org/1nee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nee RCSB], [http://www.ebi.ac.uk/pdbsum/1nee PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nee ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nee OCA], [https://pdbe.org/1nee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nee RCSB], [https://www.ebi.ac.uk/pdbsum/1nee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nee ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/IF2B_METTH IF2B_METTH]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
+[https://www.uniprot.org/uniprot/IF2B_METTH IF2B_METTH] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 34: / Line 34: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Arrowsmith, C]]
+[[Category: Methanothermobacter thermautotrophicus]]
-[[Category: Gehring, K]]
+[[Category: Arrowsmith C]]
-[[Category: Gutierrez, P]]
+[[Category: Gehring K]]
-[[Category: Siddiqui, N]]
+[[Category: Gutierrez P]]
-[[Category: Trempe, J F]]
+[[Category: Siddiqui N]]
-[[Category: Mixed alpha-beta structure]]
+[[Category: Trempe JF]]
-[[Category: Translation]]
-[[Category: Two domain protein]]
-[[Category: Zinc finger]]

1nee

From Proteopedia

Current revision

Structure of archaeal translation factor aIF2beta from Methanobacterium thermoautrophicum

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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