Topoisomerase 3D structures

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:38, 28 December 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 26: Line 26:
**[[1a41]] – VvTOPI C-terminal – Vaccinia virus<br />
**[[1a41]] – VvTOPI C-terminal – Vaccinia virus<br />
**[[1vcc]] – VvTOPI N-terminal<br />
**[[1vcc]] – VvTOPI N-terminal<br />
-
**[[5d5h]], [[5uj1]], [[5ujy]] - MtTOPI – ''Mycobacterium tuberculosis''<br />
+
**[[5d5h]], [[5uj1]], [[5ujy]], [[8tfg]] - MtTOPI – ''Mycobacterium tuberculosis''<br />
-
**[[6cq2]], [[6cqi]] – MtTOPI + DNA<br />
+
**[[6cq2]], [[6cqi]], [[8czq]] – MtTOPI + DNA<br />
**[[3igc]], [[2h7f]], [[2h7g]] – TOPI+DNA – Smallpox virus<br />
**[[3igc]], [[2h7f]], [[2h7g]] – TOPI+DNA – Smallpox virus<br />
**[[2gai]], [[2gaj]] – TOPI – ''Thermotoga maritime''<br />
**[[2gai]], [[2gaj]] – TOPI – ''Thermotoga maritime''<br />
**[[2f4q]] – TOPIB – ''Deinococcus radiodurans''<br />
**[[2f4q]] – TOPIB – ''Deinococcus radiodurans''<br />
**[[6ozw]] – TOPI N terminal – ''Streptococcus mutans''<br />
**[[6ozw]] – TOPI N terminal – ''Streptococcus mutans''<br />
 +
**[[6pcm]] – TOPI + DNA – ''Mycolicibacterium smegmatis''<br />
 +
**[[6z01]], [[6z03]] – TOPI – ''Candidatus caldarcheum subterraneum''<br />
 +
**[[8sjh]], [[8sji]] – TOPI - synthetic<br />
*Topoisomerase I (ATP-dependent) is reverse gyrase. See [[Gyrase]]
*Topoisomerase I (ATP-dependent) is reverse gyrase. See [[Gyrase]]
-
*TOPII see [[Gyrase]]
+
*Topoisomerase II
-
*Topoisomerase IIA or DNA gyrase
+
**[[7l6s]] – TOPII ATPase and transducer domain 103-525 - baboon<br />
 +
**[[6ca8]] – TOPII DNA-binding domain 469-1212 – ''Plasmodium falciparum''<br />
 +
**[[8j9y]], [[8j9z]] – TOPII – African swine fever virus – Cryo EM<br />
 +
 
 +
*Topoisomerase IIA
**[[1zxm]] – hTOPIIA+AMP-PNP <br />
**[[1zxm]] – hTOPIIA+AMP-PNP <br />
Line 43: Line 50:
**[[4fm9]] - hTOPIIA+DNA<br />
**[[4fm9]] - hTOPIIA+DNA<br />
**[[5gwk]] - hTOPIIA+DNA + drug<br />
**[[5gwk]] - hTOPIIA+DNA + drug<br />
 +
**[[6zy5]], [[6zy6]], [[6zy7]], [[6zy8]] - hTOPIIA+DNA + AMPPNP – Cryo EM<br />
**[[3l4j]] – yTOPII apo+DNA <br />
**[[3l4j]] – yTOPII apo+DNA <br />
**[[3l4k]] - yTOPII+DNA+Zn<br />
**[[3l4k]] - yTOPII+DNA+Zn<br />
Line 50: Line 58:
**[[1pvg]] – yTOPII N-terminal<br />
**[[1pvg]] – yTOPII N-terminal<br />
**[[1bjt]], [[1bgw]] – yTOPII core<br />
**[[1bjt]], [[1bgw]] – yTOPII core<br />
-
**[[3ksa]], [[2ksb]] – SpTOPIIA+DNA – ''Streptococcus pneumoniae''<br />
+
**[[8gcc]] – TOPIIA + DNA + inhibitor – ''Trypanosoma cruzi'' – Cryo EM<br />
-
**[[4elz]] – TOPII residues 362-493 + CCDB – ''Vibrio fischeri''<br />
+
-
**[[6rkw]], [[6rks]], [[6rku]], [[6rkv]] - EcTOPIIA subunit A+B + DNA – Cryo EM<br />
+
-
**[[6f94]], [[6f8j]], [[6f86]] - EcTOPIIA subunit B + inhibitor<br />
+
-
**[[6eng]] - EcTOPIIA subunit B ATPase domain + aminocoumarin<br />
+
-
**[[6gav]], [[6gau]] - MtTOPIIA subunit A+B <br />
+
*Topoisomerase IIB topo VI
*Topoisomerase IIB topo VI
**[[4j3n]] - hTOPIIB subunit A+B + DNA <br />
**[[4j3n]] - hTOPIIB subunit A+B + DNA <br />
-
**[[5zrf]] - hTOPIIB subunit B + DNA <br />
+
**[[5zrf]], [[5zen]], [[5zqf]] - hTOPIIB subunit B + DNA <br />
-
**[[5z9n]], [[5z9m]], [[5z9l]], [[5z9f]], [[5z9e]], [[5z9b]], [[5z4o]], [[5z4h]] - hTOPIIB subunit B + inhibitor <br />
+
**[[4g0w]], [[3qx3]], [[4g0v]], [[4g0u]], [[5gwj]], [[5gwi]] - hTOPIIB + DNA + anti-cancer drug<br />
**[[4g0w]], [[3qx3]], [[4g0v]], [[4g0u]], [[5gwj]], [[5gwi]] - hTOPIIB + DNA + anti-cancer drug<br />
 +
**[[7qfn]] - hTOPIIB ATPase domain 50-449 + ADP <br />
 +
**[[7qfo]] - hTOPIIB ATPase domain + AMPPNP <br />
 +
**[[7zbg]] - hTOPIIB ATPase domain + ADP + piperazine derivative <br />
**[[2zbk]] – SsTOPIIB subunit A+B – ''Sulfolobus shibatae''<br />
**[[2zbk]] – SsTOPIIB subunit A+B – ''Sulfolobus shibatae''<br />
**[[2hkj]], [[1mu5]], [[1mx0]] - SsTOPIIB subunit B<br />
**[[2hkj]], [[1mu5]], [[1mx0]] - SsTOPIIB subunit B<br />
Line 78: Line 83:
**[[2o19]], [[2o54]], [[2o59]], [[2o5c]], [[2o5e]], [[1i7d]] – EcTOPIII+DNA <br />
**[[2o19]], [[2o54]], [[2o59]], [[2o5c]], [[2o5e]], [[1i7d]] – EcTOPIII+DNA <br />
**[[1d6m]] - EcTOPIII<br />
**[[1d6m]] - EcTOPIII<br />
 +
**[[6k8n]] – SsTOPIII – Sulfolobus solfataricus<br />
 +
**[[6k8o]] – SsTOPIII + DNA<br />
*Topoisomerase IV
*Topoisomerase IV
-
**[[1zvt]], [[1zvu]] - EcTOPIV subunit A<br />
+
**[[3fv5]] – EcTOPIV ParE subunit <br />
-
**[[3fv5]], [[1s14]] – EcTOPIV subunit B <br />
+
**[[1zvt]], [[1zvu]] - EcTOPIV ParC subunit <br />
-
**[[6bq9]] - EcTOPIV subunit A N-terminal - ''Pseudomonas putida''<br />
+
**[[1s14]] – EcTOPIV ParE subunit<br />
-
**[[2nov]] - SpTOPIV subunit A<br />
+
**[[2nov]] - SpTOPIV ParC subunit <br />
-
**[[2inr]] - SaTOPIV subunit A – ''Staphylococcus aureus''<br />
+
**[[2inr]] - SaTOPIV ParC subunit <br />
-
**[[1wp5]] – TOPIV C-terminal – ''Geobacillus stearothermophilus''<br />
+
**[[1wp5]] – TOPIV C-terminal – ''Geobacillus stearothermophilus<''br />
-
**[[2xkj]] – AbTOPIV pare+parc subunits – ''Acinetobacter baumannii''<br />
+
**[[2xkj]] – AbTOPIV ParE+ParC subunits – ''Acinetobacter baumannii''<br />
-
**[[3lnu]], [[3lps]] - TOPIV subunit B N-terminal – ''Xanthomonas oryzae''<br />
+
**[[3lnu]], [[3lps]] - XoTOPIV ParE subunit N-terminal – ''Xanthomonas oryzae''<br />
 +
**[[6bq9]] - TOPIV ParC NTD – ''Pseudomonas putida''<br />
*Topoisomerase IV complexes
*Topoisomerase IV complexes
-
**[[4hxz]], [[4hy1]] - hTOPIV subunit B + inhibitor<br />
+
**[[4hxz]], [[4hy1]] - hTOPIV ParE subunit + inhibitor<br />
-
**[[4hz0]] - EcTOPIV subunit B + inhibitor<br />
+
**[[4hz0]] - EcTOPIV ParE subunit + inhibitor<br />
-
**[[4mn4]] - EcTOPIV subunit A + MukB<br />
+
**[[4mn4]] - EcTOPIV ParC subunit + MukB<br />
-
**[[1s16]] - EcTOPIV subunit B + ADPNP<br />
+
**[[1s16]] - EcTOPIV ParE subunit +ADPNP<br />
-
**[[3ksb]], [[4i3h]] - SpTOPIV subunit A+B + DNA<br />
+
**[[3ksb]], [[4i3h]], [[2ksb]] - SpTOPIV ParE + ParC subunits +DNA - ''Streptococcus pneumoniae''<br />
-
**[[4juo]], [[4koe]], [[3rae]], [[3rad]], [[3k9f]], [[4z53]], [[4z4q]], [[4z3o]] - SpTOPIV subunit A+B + DNA + drug<br />
+
**[[4juo]], [[4koe]], [[3rae]], [[3rad]], [[3k9f]] - SpTOPIV ParE + ParC subunits +DNA + floxacin derivative<br />
-
**[[4kpe]], [[3foe]], [[3fof]], [[4kpf]] - SpTOPIV subunit A+B (mutant) + DNA + quinolone derivative<br />
+
**[[4kpe]], [[3foe]], [[3fof]], [[4kpf]] - SpTOPIV ParE + ParC subunits (mutant) +DNA + quinolone derivative<br />
-
**[[3raf]], [[3ltn]] - SpTOPIV subunit A+B + DNA + quinazoline derivative<br />
+
**[[3raf]], [[3ltn]] - SpTOPIV ParE + ParC subunits +DNA+quinazoline derivative<br />
-
**[[4em7]], [[4emv]], [[4lp0]], [[4lpb]], [[4mb9]], [[4mbc]], [[4mot]], [[5boc]], [[5bod]], [[5yig]] - SpTOPIV subunit B + inhibitor<br />
+
**[[4z53]], [[4z4q]], [[4z3o]] - SpTOPIV ParE + ParC subunits +DNA+ drug<br />
-
**[[5j5q]], [[5j5p]] - SpTOPIV subunit B + DNA<br />
+
**[[4em7]], [[4emv]], [[4lp0]], [[4lpb]], [[4mb9]], [[4mbc]], [[4mot]], [[5boc]], [[5bod]], [[5yig]] - SpTOPIV ParE subunit + inhibitor<br />
-
**[[4url]], [[4urn]] - SaTOPIV subunit B N terminal + antibiotic<br />
+
**[[5j5q]], [[5j5p]] - SpTOPIV ParE subunit + DNA<br />
-
**[[2xkk]] - AbTOPIV pare+parc subunits + DNA + moxifloxacin<br />
+
**[[4url]], [[4urn]] - SaTOPIV ParE subunit N terminal + antibiotic<br />
-
**[[4hym]], [[4kqv]] - TOPIV subunit B + inhibitor – ''Francisella tularensis''<br />
+
**[[2xkk]] - AbTOPIV ParE + ParC subunits +DNA<br />
-
**[[4hz5]] - TOPIV subunit B + inhibitor – ''Enterococcus faecalis''<br />
+
**[[4hym]], [[4kqv]] - TOPIV ParE subunit + inhibitor – ''Francisella tularensis''<br />
-
**[[5eix]] - TOPIV subunit B + DNA + levofloxacin – ''Klebsiella pneumoniae''<br />
+
**[[4hz5]] - TOPIV ParE subunit + inhibitor – ''Enterococcus faecalis''<br />
 +
**[[5eix]] - KpTOPIV ParE subunit + DNA + levofloxacin – ''Klebsiella pneumoniae''<br />
 +
**[[6waa]], [[7lhz]] - KpTOPIV ParE CTD + ParC NTD + DNA + inhibitor<br />
 +
**[[7cmp]] - XoTOPIV ParE subunit + AMPPNP<br />
*Topoisomerase V
*Topoisomerase V
-
**[[2csb]], [[2csd]], [[4gfj]] – TOPV – ''Methanopyrus kandleri''<br />
+
**[[2csb]], [[2csd]] – MkTOPV 1-519 – ''Methanopyrus kandleri''<br />
-
**[[3m6k]], [[3m7g]], [[5hm5]] – MkTOPV N-terminal<br />
+
**[[5hm5]] - MkTOPV 1-854 <br />
-
**[[3m6z]] - MkTOPV N-terminal+guanidine<br />
+
**[[4gfj]] – MkTOPV 1-685<br />
-
**[[3m7d]] - MkTOPV N-terminal+dioxane
+
**[[3m6k]] – MkTOPV 1-380<br />
 +
**[[3m7g]] – MkTOPV 1-269<br />
 +
**[[3m6z]] - MkTOPV 1-380 +guanidine<br />
 +
**[[3m7d]] - MkTOPV 1-380 +dioxane<br />
 +
**[[3m6z]], [[8df7]], [[8df8]], [[8df9]], [[8dfb]] - MkTOPV (mutant) 1-854 + DNA<br />
 +
 
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Topoisomerase

Updated on 28-December-2023 - For a general description of the protein see Topoisomerase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

Retrieved from "http://52.214.119.220/wiki/index.php/Topoisomerase_3D_structures"
Personal tools