Topoisomerase 3D structures

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**[[1a41]] – VvTOPI C-terminal – Vaccinia virus<br />
**[[1a41]] – VvTOPI C-terminal – Vaccinia virus<br />
**[[1vcc]] – VvTOPI N-terminal<br />
**[[1vcc]] – VvTOPI N-terminal<br />
-
**[[5d5h]], [[5uj1]], [[5ujy]] - MtTOPI – ''Mycobacterium tuberculosis''<br />
+
**[[5d5h]], [[5uj1]], [[5ujy]], [[8tfg]] - MtTOPI – ''Mycobacterium tuberculosis''<br />
-
**[[6cq2]], [[6cqi]] – MtTOPI + DNA<br />
+
**[[6cq2]], [[6cqi]], [[8czq]] – MtTOPI + DNA<br />
**[[3igc]], [[2h7f]], [[2h7g]] – TOPI+DNA – Smallpox virus<br />
**[[3igc]], [[2h7f]], [[2h7g]] – TOPI+DNA – Smallpox virus<br />
**[[2gai]], [[2gaj]] – TOPI – ''Thermotoga maritime''<br />
**[[2gai]], [[2gaj]] – TOPI – ''Thermotoga maritime''<br />
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**[[6ozw]] – TOPI N terminal – ''Streptococcus mutans''<br />
**[[6ozw]] – TOPI N terminal – ''Streptococcus mutans''<br />
**[[6pcm]] – TOPI + DNA – ''Mycolicibacterium smegmatis''<br />
**[[6pcm]] – TOPI + DNA – ''Mycolicibacterium smegmatis''<br />
 +
**[[6z01]], [[6z03]] – TOPI – ''Candidatus caldarcheum subterraneum''<br />
 +
**[[8sjh]], [[8sji]] – TOPI - synthetic<br />
*Topoisomerase I (ATP-dependent) is reverse gyrase. See [[Gyrase]]
*Topoisomerase I (ATP-dependent) is reverse gyrase. See [[Gyrase]]
-
*TOPII see [[Gyrase]]
+
*Topoisomerase II
-
*Topoisomerase IIA or DNA gyrase
+
**[[7l6s]] – TOPII ATPase and transducer domain 103-525 - baboon<br />
 +
**[[6ca8]] – TOPII DNA-binding domain 469-1212 – ''Plasmodium falciparum''<br />
 +
**[[8j9y]], [[8j9z]] – TOPII – African swine fever virus – Cryo EM<br />
 +
 
 +
*Topoisomerase IIA
**[[1zxm]] – hTOPIIA+AMP-PNP <br />
**[[1zxm]] – hTOPIIA+AMP-PNP <br />
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**[[4fm9]] - hTOPIIA+DNA<br />
**[[4fm9]] - hTOPIIA+DNA<br />
**[[5gwk]] - hTOPIIA+DNA + drug<br />
**[[5gwk]] - hTOPIIA+DNA + drug<br />
 +
**[[6zy5]], [[6zy6]], [[6zy7]], [[6zy8]] - hTOPIIA+DNA + AMPPNP – Cryo EM<br />
**[[3l4j]] – yTOPII apo+DNA <br />
**[[3l4j]] – yTOPII apo+DNA <br />
**[[3l4k]] - yTOPII+DNA+Zn<br />
**[[3l4k]] - yTOPII+DNA+Zn<br />
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**[[1pvg]] – yTOPII N-terminal<br />
**[[1pvg]] – yTOPII N-terminal<br />
**[[1bjt]], [[1bgw]] – yTOPII core<br />
**[[1bjt]], [[1bgw]] – yTOPII core<br />
 +
**[[8gcc]] – TOPIIA + DNA + inhibitor – ''Trypanosoma cruzi'' – Cryo EM<br />
*Topoisomerase IIB topo VI
*Topoisomerase IIB topo VI
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**[[5zrf]], [[5zen]], [[5zqf]] - hTOPIIB subunit B + DNA <br />
**[[5zrf]], [[5zen]], [[5zqf]] - hTOPIIB subunit B + DNA <br />
**[[4g0w]], [[3qx3]], [[4g0v]], [[4g0u]], [[5gwj]], [[5gwi]] - hTOPIIB + DNA + anti-cancer drug<br />
**[[4g0w]], [[3qx3]], [[4g0v]], [[4g0u]], [[5gwj]], [[5gwi]] - hTOPIIB + DNA + anti-cancer drug<br />
 +
**[[7qfn]] - hTOPIIB ATPase domain 50-449 + ADP <br />
 +
**[[7qfo]] - hTOPIIB ATPase domain + AMPPNP <br />
 +
**[[7zbg]] - hTOPIIB ATPase domain + ADP + piperazine derivative <br />
**[[2zbk]] – SsTOPIIB subunit A+B – ''Sulfolobus shibatae''<br />
**[[2zbk]] – SsTOPIIB subunit A+B – ''Sulfolobus shibatae''<br />
**[[2hkj]], [[1mu5]], [[1mx0]] - SsTOPIIB subunit B<br />
**[[2hkj]], [[1mu5]], [[1mx0]] - SsTOPIIB subunit B<br />
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**[[1wp5]] – TOPIV C-terminal – ''Geobacillus stearothermophilus<''br />
**[[1wp5]] – TOPIV C-terminal – ''Geobacillus stearothermophilus<''br />
**[[2xkj]] – AbTOPIV ParE+ParC subunits – ''Acinetobacter baumannii''<br />
**[[2xkj]] – AbTOPIV ParE+ParC subunits – ''Acinetobacter baumannii''<br />
-
**[[3lnu]], [[3lps]] - TOPIV ParE subunit N-terminal – ''Xanthomonas oryzae''<br />
+
**[[3lnu]], [[3lps]] - XoTOPIV ParE subunit N-terminal – ''Xanthomonas oryzae''<br />
**[[6bq9]] - TOPIV ParC NTD – ''Pseudomonas putida''<br />
**[[6bq9]] - TOPIV ParC NTD – ''Pseudomonas putida''<br />
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**[[4hz5]] - TOPIV ParE subunit + inhibitor – ''Enterococcus faecalis''<br />
**[[4hz5]] - TOPIV ParE subunit + inhibitor – ''Enterococcus faecalis''<br />
**[[5eix]] - KpTOPIV ParE subunit + DNA + levofloxacin – ''Klebsiella pneumoniae''<br />
**[[5eix]] - KpTOPIV ParE subunit + DNA + levofloxacin – ''Klebsiella pneumoniae''<br />
-
**[[6waa]] - KpTOPIV ParE CTD + ParC NTD + DNA + inhibitor<br />
+
**[[6waa]], [[7lhz]] - KpTOPIV ParE CTD + ParC NTD + DNA + inhibitor<br />
 +
**[[7cmp]] - XoTOPIV ParE subunit + AMPPNP<br />
*Topoisomerase V
*Topoisomerase V
-
**[[2csb]], [[2csd]], [[4gfj]] – TOPV – ''Methanopyrus kandleri''<br />
+
**[[2csb]], [[2csd]] – MkTOPV 1-519 – ''Methanopyrus kandleri''<br />
-
**[[3m6k]], [[3m7g]], [[5hm5]] – MkTOPV N-terminal<br />
+
**[[5hm5]] - MkTOPV 1-854 <br />
-
**[[3m6z]] - MkTOPV N-terminal+guanidine<br />
+
**[[4gfj]] – MkTOPV 1-685<br />
-
**[[3m7d]] - MkTOPV N-terminal+dioxane
+
**[[3m6k]] – MkTOPV 1-380<br />
 +
**[[3m7g]] – MkTOPV 1-269<br />
 +
**[[3m6z]] - MkTOPV 1-380 +guanidine<br />
 +
**[[3m7d]] - MkTOPV 1-380 +dioxane<br />
 +
**[[3m6z]], [[8df7]], [[8df8]], [[8df9]], [[8dfb]] - MkTOPV (mutant) 1-854 + DNA<br />
 +
 
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Topoisomerase

Updated on 28-December-2023 - For a general description of the protein see Topoisomerase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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