Transcriptional activator 3D structures

*Gcn4 TA See [[Gcn4]]

*Gcn5 TA

*C-Myb TA; domains – DBD ; DBD repeat 1 38-89; repeat 2 90-141; repeat 3 142-193; transcription activation 291-315

**[[1mse]], [[1msf]] – mTA DBD 90-193 + DNA – NMR - mouse<br />

**[[1mbe]], [[1mbf]] – mTA DBD repeat 1 + DNA - NMR<br />

**[[1h88]] – mTA DBD + DNA + CCAAT/enhancer binding protein β<br />

**[[1h89]] – mTA DBD + DNA + CAAT/enhancer binding protein β<br />

**[[1sb0]], [[2agh]] – mTA transcription activation domain + CREB-binding protein - NMR<br />

**[[6dmx]], [[6dnq]] – mTA transcription activation domain + CREB-binding protein p3ptide + Bzip factor <br />

*Psp operon TA

**[[2bjw]] – EcTA AAA domain –'' Escherichia coli''<br />

**[[5nss]] – EcTA in RNA polymerase complex – Cryo EM<br />

*TenA TA

**[[1udd]] – TA – ''Pyrococcus horikishii''<br />

*LasR TA or transcriptional regulator LasR

**[[2uv0]] – PaTA LBD residues 1-173 <br />

**[[3ix3]], [[6mvn]], [[6mvm]] – PaTA LBD + oxo-dodecanoyl-homoserine lactone<br />

**[[3ix4]], [[3ix8]], [[3jpu]], [[6d6a]], [[6d6b]], [[6d6c]], [[6d6d]], **[[6d6p]], [[6d6l]], [[6d6m]], [[6d6o]], [[6d6n]] – PaTA LBD + benzoate derivative<br />

**[[6v7w]], [[6v7x]] – PaTA + Aqs1<br />

*CadC TA

**[[3ly7]], [[3lya]] – EcTA periplasmic domain 188-512<br />

**[[5ju7]] – EcTA DBD 2-107<br />

*Mal-Rpel TA

*Brg1 TA

**[[5ea1]] – hTA bromodomain 1418-1536 - human<br />

**[[3uvd]] – hTA bromodomain - NMR<br />

**[[2grc]], [[3uvd]], [[5dkd]], [[6zs2]] – hTA bromodomain + inhibitor<br />

**[[6hr2]] – hTA bromodomain + ElonginB + ElonginC + pVHL<br />

*Flagelar TA

**[[1g8e]] – EcTA FlhD<br />

**[[2avu]] – EcTA FlhC+FLHD<br />

**[[5hxg]] – StTA FlhD + STM1697 <br />

*Tipa TA

**[[1r8d]] – BsTA <br />

*Rfah TA

**[[5ond]] – EcTA + DNA <br />

*SoxR TA or redox-sensitive transcriptional activator

**[[6tf4]] – VcTA C terminal - ''Vibrio cholera'' - NMR<br />

*GlxR TA

**[[3r6s]] – CgTA +cAMP – ''Corynebacterium glutamicum'' <br />

**[[4byy]] – CgTA <br />

*OxyR TA or hydrogen peroxide-inducible genes activator

**[[7l4s]] – TA regulatory domain – ''Shewnella oneidensis''<br />

**[[4y0m]] – PaTA regulatory domain <br />

**[[4x6g]], [[4xws]] – PaTA regulatory domain (mutant)<br />

**[[1i69]], [[1i6a]] – EcTA regulatory domain (mutant)<br />

**[[6g1d]] – CgTA regulatory domain (mutant)<br />

**[[6g1b]], [[6g4r]] – CgTA regulatory domain + H2O2<br />

**[[5x0v]] – VvTA - ''Vibrio vulnificus''<br />

**[[5b70]], [[5b7d]], [[5b7h]], [[5x0q]] – VvTA (mutant) <br />

**[[3jv9]] – NmTA – ''Neisseria meningitidis'' <br />

*PlcR TA

**[[2qfc]] – BtTA + PapR peptide <br />

**[[3u3w]] – BtTA + DNA + PapR peptide <br />

*VirB TA or virulence regulon transcriptional activator VirB

*MafA TA

*CysB TA or Cys regulon transcriptional activator CysB

**[[5z4y]], [[5z4z]] – PaTA NTD domain <br />

*HlyU TA

**[[4k2e]], [[4ooi]] – VcTA <br />

**[[5znx]] – VvTA + inhibitor <br />

*ToxR TA

**[[6uue]], [[6utc]] – VvTA <br />

**[[8b4b]], [[8b4c]], [[8b4d]], [[8b4e]] – VcTA + DNA<br />

**[[8alo]] – VcTA + ToxS<br />

*LysR TA

**[[5x0o]] – VvTA <br />

**[[4pzj]] – TA – ''Eggerthella lenta''<br />

**[[5xxp]], [[7d98]] – CnTA + DNA<br />

**[[1uth]], [[2y7r]], [[5ae4]] – TA – ''Burkholderia cepacia''<br />

**[[7fdf]] – CsTA regulatory domain (mutant) <br />

*Aft2 TA

**[[4lmg]] – yTA + DNA<br />

*Mga TA

**[[5way]] – SpTA – ''Streptococcus pneumoniae''<br />

*Spt7 TA

*Quorum-sensing TA or TraR

**[[5l07]] – YeTA – ''Yersinia enterocolitica''<br />

**[[5l09]] – YeTA + THF derivative<br />

**[[1l3l]] – AtTA + pheromone + DNA – ''Agrobacterium tumefaciens'' <br />

**[[1h0m]] – AtTA + auto-inducer + DNA <br />

*MexT TA

**[[6l33]] – PaTA regulatory domain<br />

*ComR TA

**[[5juf]], [[6qer]] – StTA – ''Streptococcus thermophilus''<br />

**[[5jub]] – StTA + DNA<br />

**[[5fd4]] – TA – ''Streptococcus suis''<br />

**[[7n10]], [[7n1n]] – SmTA DBD + Prx – ''Streptococcus mutans''<br />

**[[6hu8]] – SvTA – ''Streptococcus vestibularis''<br />

**[[6hua]] – SvTA + peptide<br />

*FasR TA

**[[6o6p]] – MtTA + DNA – ''Mycobacterium tuberculosis''<br />

**[[6o6o]] – MtTA + myristic acid<br />

**[[6o6n]] – MtTA + arachinoyl-CoA<br />

*ModE TA

**[[1o7l]], [[1h9s]] – EcTA + Mo <br />

**[[1b9m]], [[1b9n]], [[1h9r]] – EcTA + Ni <br />

*TetR family TA

**[[1z77]], [[2id6]], [[2iek]], [[1zkg]], [[4i76]], [[3ih2]], [[3ih3]], [[3ih4]] – TmTA – ''Thermotoga maritima''<br />

**[[4i6z]] – TmTA + DNA<br />

**[[1zk8]], [[2fq4]], [[4me9]] – BcTA – ''Bacillus cereus''<br />

**[[3cwr]] – TA – ''Rhodspirillum rubrum''<br />

**[[1z0x]] – EfTA – ''Enterococcus faecalis''<br />

**[[3c2b]] – AfTA – ''Agrobacterium fabrum''<br />

**[[2o7t]] – CgTA <br />

**[[2g7s]] – AtTA <br />

**[[3gzi]] – TA – ''Shewanella loihica''<br />

**[[2qib]], [[2zcx]], [[7ky1]] – ScTA – ''Streptomyces coelicolor''<br />

**[[2hyt]] – TA – ''Pectobacterium atrosepticum''<br />

**[[3cdl]] – PsTA – ''Pseudomonas syringae''<br />

**[[3kkc]] – SaTA – ''Streptococcus agalactiae''<br />

**[[3nnr]] – TA – ''Marinobacter aquaeolei''<br />

**[[3on4]] – TA – ''Legionella pneumophila''<br />

**[[3f1b]] – RjTA – ''Rhodococcus jostii''<br />

**[[3eup]] – TA – ''Cytophaga hutchinsoni''i<br />

**[[3egq]] – TA – ''Archaeoglobus fulgidus''<br />

**[[4hku]] – LmTA – Listeria monocytogenes<br />

**[[3nrg]], [[3qbm]] – TA – ''Chlotoflexus aurantiacus''<br />

**[[6nsr]] – PaTA (mutant) + DNA<br />

**[[4jkz]] – MsTA – ''Mycobacterium smegmatis''<br />

**[[6el2]] – SacTA – ''Sulfolobus acidocaldarius''<br />

**[[6en8]] – SacTA + DNA<br />

*TetR/AcrR family TA

**[[2rae]] – RjTA <br />

**[[3lhq]] – StTA <br />

**[[3b81]] – CpTA – ''Clostridium acetobutylicum''<br />

**[[3dcf]] – TA – ''Thermobifida fusca''<br />

**[[3mvp]] – SmTA <br />

**[[5d18]], [[5d19]], [[6a4l]], [[6a4w]] – MtTA <br />

**[[2eh3]] – TA – ''Aquifex aeolicus''<br />

**[[3vuq]] – TtTA – ''Thermus thermophilus''<br />

**[[7eqe]] – SgTA – ''Streptococcus griseus''<br />

**[[7eqf]] – SgTA + ligand<br />

**[[5gp9]], [[5gpa]] – BhTA – ''Bacillus halodurans''<br />

**[[5gpc]] – BhTA + DNA <br />

**[[6g87]] – BdTA – ''Bradyrhizobium diazoefficiens''<br />

**[[6g8h]] – BdTA + naringenin <br />

**[[6g8g]] – BdTA + genistein <br />

*GntR family TA

**[[3l5z]] – BcTA <br />

**[[3ddv]] – EfTA <br />

**[[3fms]], [[3sxy]] – TmTA <br />

**[[3c7j]] – PsTA <br />

**[[2di3]], [[2p19]] – CgTA <br />

**[[3tqn]] – TA –'' Coxiella burnetii''<br />

**[[6za0]], [[6za3]], [[7za7]] – AfTA <br />

**[[6z74]], [[6zab]] – AfTA + DNA<br />

**[[7u5q]] – TA – ''Brucella melitensis''<br />

**[[6sbs]] – SacTA <br />

**[[3h5o]] – TA – ''Chromobacterium violaceum'' <br />

**[[6az6]], [[7b5t]], [[7b5y]], [[7b5w]] – SaTA <br />

**[[7b5u]] – SaTA + diAMP <br />

**[[7oz3]] – SaTA + DNA – Cryo EM<br />

**[[4r1h]] – LmTA <br />

**[[3ihu]] – TA – ''Ralstonia eutropha'' <br />

**[[3lhe]] – TA – ''Bacillus anthracis'' <br />

**[[3f8m]] – MsTA <br />

*MarR family TA or multiple antibiotic resistance protein

**[[3boq]], [[3cjn]], [[3e6m]] – RpTA - ''Ruegeria pomeryi''<br />

**[[3s2w]] – TA – ''Methanosarcina mazei'' <br />

**[[3bpv]] – TA – ''Methanobacterium thermoautotrophicum'' <br />

**[[2fbk]] – DrTA –'' Deinococcus radiodurans''<br />

**[[5dd8]] – DrTA (mutant) <br />

**[[2fa5]] – TA – ''Xanthomonas campestris''<br />

**[[3g3z]], [[5aiq]] – NmTA <br />

**[[5aip]] – NmTA + hydroxyphenylacetate <br />

**[[5e1w]] – DmTA – ''Dihalococcoides mccartyi''<br />

**[[5e1z]], [[5e1x]], [[5e20]] – DmTA + phenol derivative <br />

**[[6c28]] – RpTA + coumaroyl-CoA – ''Rhodopseudomonas palustris'' <br />

**[[3fm5]] – RjTA <br />

**[[1z91]] – BsTA <br />

**[[4b8x]] – ScTA <br />

**[[4yif]] – MtTA <br />

**[[3vb2]], [[3voe]], [[4jba]] – EcTA <br />

**[[3vod]] – EcTA (mutant)<br />

**[[5h3r]] – EcTA (mutant) + DNA<br />

**[[5eri]] – CdTA – ''Clostridium difficile''<br />

**[[7dvn]] – TA + effector –'' Paenisporosarcina''<br />

**[[3u2r]] – TA – ''Planctopirus limnophilus''<br />

**[[2rdp]] – TA – ''Bacillus stearothermophilus''<br />

*MerR family TA or mercuric resistance operon regulatory protein

**[[3hh0]] – BcTA <br />

**[[3gpv]] – BtTA <br />

**[[4ua1]], [[4ua2]] – TA – ''Bacillus megaterium''<br />

**[[5crl]] – PaTA <br />

**[[5gpe]] – TA – ''Cupriavidus metallidurans''<br />

**[[3cnb]] – TA – ''Colwellia psychrerythraea'' <br />

**[[6d90]] – HiTA – ''Haemophilia influenzae''<br />

**[[5d8c]] – HiTA + DNA <br />

**[[6xl6]], [[6xla]], [[6xlk]] – EcTA + DNA – Cryo EM<br />

**[[6xl5]], [[6xl9]], [[6xlj]] – EcTA in RNP complex – Cryo EM<br />

*AsnC family TA

**[[3i4p]] – AfTA <br />

**[[2cg4]] – EcTA <br />

*AraC family TA or arabinose operon regulatory protein

**[[3gra]] – PpTA – ''Pseudomonas putida''<br />

**[[3cu5]] – TA – ''Lacnoclostridium phytofermentans''<br />

**[[5chh]] – PaTA <br />

**[[2ara]] – EcTA <br />

**[[1xja]] – EcTA dimerization domain (mutant)<br />

**[[2k9s]] – EcTA DBD - NMR<br />

**[[2arc]] – EcTA + arabinose<br />

**[[2aac]] – EcTA + fucose<br />

*LacI family TA

**[[3kjx]], [[3e3m]] – RpTA <br />

**[[3jy6]] – TA - ''Lactobacillus brevis'' <br />

**[[6chk]] – LcTA - ''Lactobacillus casei'' <br />

**[[4rk5]], [[4rk4]] – LcTA + sugar <br />

**[[4rk0]], [[4rk1]] – EfTA + ribose<br />

**[[3h5t]] – CgTA <br />

**[[3kke]] – MsTA <br />

**[[4rkq]], [[4rkr]] – TA - ''Arthrobacter''<br />

*PadR family TA

**[[5zhv]], [[5zi8]], [[5zhc]] – MtTA <br />

**[[5zqh]] – SpTA <br />

**[[5x12]], [[7cbv]] – BsTA <br />

**[[5x13]], [[5y8t]] – BsTA + coumaric acid<br />

**[[5x14]] – BsTA + ferulic acid<br />

**[[6abq]], [[6abt]] – LmTA <br />

**[[5dym]] – CdTA <br />

*TrmB TA or tRNA (guanine-N(7)-) methyltransferase

**[[2f5t]] – TA – ''Thermococcus litoralis''<br />

**[[3qph]] – PfTA + sucrose – ''Pyrococcus furiosus''<br />

*IclR TA

**[[1mkm]] – TmTA <br />

**[[2o99]], [[2o9a]] – EcTA C-terminal <br />

**[[1td5]] – EcTA LBD <br />

**[[7cuo]] – TA + hydroxybenzoate – ''Microbacterium hydrocarbonoxydans <br />

''

*BgaR TA

**[[6nwo]] – CpTA – ''Clostridium perfringens''<br />

**[[6nx3]], [[6nwj]], [[6nwm]], [[6nwh]] – CpTA + pyranose derivative<br />

*SlyA TA

**[[1lj9]] – EfTA <br />

**[[3qpt]] – StTA <br />

**[[3q5f]] – StTA + DNA <br />

**[[4aih]] – YpTA – ''Yersinia pseudotuberculosis''<br />

**[[4aij]], [[4aik]] – YpTA + DNA <br />

*CouR TA

**[[5cyv]], [[6c28]] – RjTA + coumaroyl-CoA –'' Rhodococcus jostii''<br />

**[[6c9t]] – RpTA <br />

**[[6c2s]] – RpTA + DNA <br />

*CueR TA

**[[1q07]], [[1q06]], [[1q05]] – EcTA <br />

*LuxR TA

**[[6wae]] – VvTA <br />

**[[6wai]], [[6wah]], [[6wag]], [[6waf]] – VvTA (mutant)<br />

*LuxT TA

**[[3b4s]], [[3ljl]] – VpTA <br />

*ClgR TA or Clp gene regulator

**[[5woq]] – MsTA <br />

**[[3f51]], [[3f52]] – CgTA <br />

*LmrR TA

**[[3f8b]], [[6i8n]] – LlTA – ''Lactococcus lactis''<br />

**[[3f8c]], [[3f8f]] – LlTA + drug<br />

**[[6vwe]], [[6do0]] – LlTA + Rh complex<br />

**[[6r1l]] – LlTA + Cu + phenanthroline<br />

**[[4zzd]] – LlTA + riboflavine<br />

**[[6fuu]] – LlTA + heme<br />

*MvfR TA

**[[4jvc]], [[6z17]] – PaTA <br />

**[[4jvd]], [[4jvi]], [[6q7u]], [[6q7v]], [[6tpr]], [[6yiz]], [[6yz3]], [[6z07]], **[[6z17]], [[6z5k]], [[7nbw]], [[7o2t]], [[7o2u]] – PaTA + inhibitor<br />

**[[6b8a]], [[6q7w]] – PaTA LBD 94-295 + inhibitor<br />

*HdfR TA

**[[6wn5]] – TA – ''Klebsiella pneumoniae''<br />

*McbR TA

**[[4p9f]] – EcTA <br />

**[[4ab5]] – MnTA <br />

**[[4ab6]] – MnTA (mutant)<br />

*MetR TA

**[[5fo5]] – EcTA DBD<br />

*YvhJ TA

**[[3nxh]] – BsTA <br />

*CgmR TA

**[[2yve]], [[2zoy]] – CgTA <br />

**[[2zoz]] – CgTA + ethidium<br />

**[[2yvh]] – CgTA + DNA<br />

*AraR TA or arabinose metabolism transcriptional repressor

**[[5bs6]], [[5dd4]] – BtTA – ''Bacterioides thetaiotaomicron''<br />

**[[3tb6]] – BtTA effector-binding domain 71-362 + arabinose<br />

**[[5ddg]] – BtTA + DNA<br />

**[[5deq]] – BtTA 1-225 + arabinose<br />

**[[4egy]], [[4egz]], [[4h0e]], [[5d4r]], [[5d4s]] – BsTA DBD 1-68 + DNA<br />

*CarH TA or light-dependent transcriptional regulator

**[[5c8a]], [[5c8d]], [[5c8e]], [[5c8f]] – TtTA + cobalamin derivative<br />

*ZitR TA or zinc transport transcriptional regulator

**[[5yhx]] – LlTA <br />

**[[5yhy]], [[5yhz]], [[5yi0]], [[5yi1]], [[6fi9]] – LlTA (mutant)<br />

**[[5yi2]] – LlTA + DNA<br />

**[[5yi3]] – LlTA (mutant) + DNA<br />

*LsrR TA

**[[4l4y]] – EcTA <br />

**[[4l4z]], [[4l50]], [[4l51]], [[4l5i]], [[4l5j]] – EcTA + ligand<br />

*TA II

**[[8igr]] – EcTA in transcription activation complex – Cryo EM<br />

*TA RAMA

**[[7bef]], [[7beg]] – EcTA in transcription activation complex – Cryo EM<br />

*PrfA TA or listeriolysin positive regulatory factor A

**[[1omi]], [[2beo]] – LmTA <br />

**[[2bgc]], [[6qvy]], [[6qvz]], [[6qw1]], [[6qw2]] – LmTA (mutant) <br />

**[[5lej]], [[5x6d]] – LmTA + DNA<br />

**[[5lek]], [[6qwf]], [[6qwh]], [[6qwk]], [[6qwm]] – LmTA (mutant) + DNA <br />

**[[5f1r]], [[6eut]], [[6euu]], [[6euz]], [[6ev0]], [[6exk]], [[6exl]], [[6exm]], [[6t5i]] – LmTA + inhibitor<br />

**[[5lrs]], [[5x6e]] – LmTA + DNA + glutathione<br />

**[[5lrr]] – LmTA + glutathione<br />

**[[6hck]] – LmTA + peptide<br />

*HTH-type TA or helix-turn-helix-type

**[[2uxu]] – PpTA TtgR + naringenin<br />

**[[2uxh]] – PpTA TtgR + quercetin<br />

**[[2uxi]] – PpTA TtgR + phloretin<br />

**[[6ugl]], [[6kju]] – VcTA + pyrazine derivative<''br />

**[[2bv6]] – SaTA MgrA –'' Staphylococcus aureus<br />

**[[5hs5]], [[5ywj]], [[6k8e]] – SaTA SarX<br />

**[[3hrm]], [[3hse]] – SaTA SarZ <br />

**[[6r1p]] – MtTA EthR <br />

**[[1ysq]] – EcTA YiaJ <br />

**[[2qop]], [[3bcg]] – EcTA AcrR<br />

**[[6ldi]], [[6xh7]], [[6xh8]], [[7c17]] – EcTA CueR in transcription activation complex – Cryo EM <br />

**[[4wls]], [[4wlw]] – EcTA CueR + DNA<br />

**[[4x1e]] – EcTA RutR<br />

**[[4xk4]], [[4jyk]] – EcTA RutR + uracil derivative<br />

**[[2hxr]] – EcTA CynR LBD <br />

**[[3hfu]] – EcTA CynR LBD + N3<br />

**[[8bob]] – EcTA MalT + MalY – Cryo EM <br />

**[[2gfn]] – RjTA Rha1 <br />

**[[1i1g]] – PfTA LrpA <br />

**[[7cla]] – TA SkgA – ''Caulobacter vibrioides''<br />

**[[7bzd]] – BsTA HxlR <br />

**[[7bze]] – BsTA HxlR (mutant)<br />

**[[7bzg]] – BsTA HxlR + DNA<br />

**[[7amn]], [[7amt]] – TA LuxR + DNA – ''Vibrio alginolyticus''<br />

**[[2dtz]], [[2hq5]] – SaTA QacR (mutant)<br />

**[[3bqz]], [[3br0]], [[3btc]], [[3btl]] – SaTA QacR (mutant) + malachite green<br />

**[[3br1]], [[3br2]], [[3bt9]], [[3btj]] – SaTA QacR (mutant) + dequalinium<br />

**[[3bti]] – SaTA QacR (mutant) + berberine<br />

**[[1qvu]],[[3br3]], [[3pm1]] – SaTA QacR (mutant) + ethidium<br />

**[[1rkw]], [[1rpw]] – SaTA QacR (mutant) + pentamadine<br />

**[[1qvt]] – SaTA QacR (mutant) + proflavine<br />

**[[3br5]], [[3br6]] – SaTA QacR (mutant) + rhodamine<br />

**[[2gby]] – SaTA QacR (mutant) + berenil<br />

**[[2g0e]] – SaTA QacR (mutant) + drug<br />

**[[3k1n]] – AbTA BenM – Acinetobacter baylyi<br />

**[[3k1p]] – AbTA BenM (mutant)<br />

**[[2f6g]], [[2f6p]], [[2f97]] – AbTA BenM effector-binding domain 81-304<br />

**[[3m1e]] – AbTA BenM DBD 1-87<br />

**[[4ihs]], [[4iht]] – AbTA BenM effector-binding domain + DNA <br />

**[[2f78]], [[2f7a]], [[2f7c]] – AbTA BenM effector-binding domain + effector <br />

**[[2h9b]] – EfTA BenM (mutant)<br />

**[[2f7b]], [[2h98]] – AbTA CatM effector-binding domain <br />

**[[3glb]] – AbTA CatM effector-binding domain (mutant)<br />

**[[2f7c]] – AbTA CatM effector-binding domain + muconate<br />

**[[2cfx]] – BsTA LrpC<br />

**[[2gqq]] – EcTA LrpC<br />

**[[6d2s]], [[6cyj]], [[6cz6]], [[6cyy]] – MtTA PrpR<br />

**[[2pju]] – EcTA PrpR<br />

**[[5t4k]], [[5t4j]], [[5t4l]], [[5x03]] – BsTA GabR EBO domain + pyridine derivative<br />

**[[4mgr]], [[4nob]], [[4tv7]] – BsTA GabR <br />

**[[6uxz]] – BsTA GabR + agonist<br />

**[[5u9e]], [[5u93]] – TA RhaR regulatory domain – ''Bacteria latreille''<br />

**[[5z49]] – TA CmpR effector-binding domain + ribulose bisphosphate – ''Synechococcus elongatus''<br />

**[[3kos]] – CfTA AmpR effector binding domain – ''Citrobacter freundii''<br />

**[[3kot]] – CfTA AmpR effector binding domain (mutant)<br />

**[[4wkm]] – CfTA AmpR effector binding domain + peptide<br />

**[[5mmh]] – PaTA AmpR effector binding domain <br />