7crc

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'''Unreleased structure'''
 
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The entry 7crc is ON HOLD until Paper Publication
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==Cryo-EM structure of plant NLR RPP1 tetramer in complex with ATR1==
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<StructureSection load='7crc' size='340' side='right'caption='[[7crc]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7crc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [https://en.wikipedia.org/wiki/Hyaloperonospora_arabidopsidis_Emoy2 Hyaloperonospora arabidopsidis Emoy2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CRC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.02&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7crc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7crc OCA], [https://pdbe.org/7crc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7crc RCSB], [https://www.ebi.ac.uk/pdbsum/7crc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7crc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9ZSN5_ARATH Q9ZSN5_ARATH]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Direct or indirect recognition of pathogen-derived effectors by plant nucleotide-binding leucine-rich repeat (LRR) receptors (NLRs) initiates innate immune responses. The Hyaloperonospora arabidopsidis effector ATR1 activates the N-terminal Toll-interleukin-1 receptor (TIR) domain of Arabidopsis NLR RPP1. We report a cryo-electron microscopy structure of RPP1 bound by ATR1. The structure reveals a C-terminal jelly roll/Ig-like domain (C-JID) for specific ATR1 recognition. Biochemical and functional analyses show that ATR1 binds to the C-JID and the LRRs to induce an RPP1 tetrameric assembly required for nicotinamide adenine dinucleotide hydrolase (NADase) activity. RPP1 tetramerization creates two potential active sites, each formed by an asymmetric TIR homodimer. Our data define the mechanism of direct effector recognition by a plant NLR leading to formation of a signaling-active holoenzyme.
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Authors:
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Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme.,Ma S, Lapin D, Liu L, Sun Y, Song W, Zhang X, Logemann E, Yu D, Wang J, Jirschitzka J, Han Z, Schulze-Lefert P, Parker JE, Chai J Science. 2020 Dec 4;370(6521). pii: 370/6521/eabe3069. doi:, 10.1126/science.abe3069. PMID:33273071<ref>PMID:33273071</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 7crc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Avirulence protein 3D structures|Avirulence protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arabidopsis thaliana]]
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[[Category: Hyaloperonospora arabidopsidis Emoy2]]
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[[Category: Large Structures]]
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[[Category: Chai JJ]]
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[[Category: Han ZF]]
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[[Category: Jirschitzka J]]
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[[Category: Lapin D]]
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[[Category: Liu L]]
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[[Category: Logemann E]]
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[[Category: Ma SC]]
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[[Category: Parker JE]]
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[[Category: SchulzeLefert P]]
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[[Category: Song W]]
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[[Category: Sun Y]]
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[[Category: Wang J]]
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[[Category: Yu DL]]
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[[Category: Zhang XX]]

Current revision

Cryo-EM structure of plant NLR RPP1 tetramer in complex with ATR1

PDB ID 7crc

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