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1d93

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[[Image:1d93.gif|left|200px]]
 
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==STRUCTURAL VARIATION IN D(CTCTAGAG). IMPLICATIONS FOR PROTEIN-DNA INTERACTIONS==
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The line below this paragraph, containing "STRUCTURE_1d93", creates the "Structure Box" on the page.
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<StructureSection load='1d93' size='340' side='right'caption='[[1d93]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1d93]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D93 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d93 OCA], [https://pdbe.org/1d93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d93 RCSB], [https://www.ebi.ac.uk/pdbsum/1d93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d93 ProSAT]</span></td></tr>
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{{STRUCTURE_1d93| PDB=1d93 | SCENE= }}
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</table>
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__TOC__
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'''STRUCTURAL VARIATION IN D(CTCTAGAG). IMPLICATIONS FOR PROTEIN-DNA INTERACTIONS'''
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Hunter WN]]
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==Overview==
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[[Category: Kennard O]]
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Single-crystal X-ray diffraction techniques have been used to characterize the structure of the self-complementary DNA oligomer d(CTCTAGAG). The structure was refined to an R factor of 14.7% using data to 2.15-A resolution. The tetragonal unit cell, space group P4(3)2(1)2, has dimensions a = 42.53 and c = 24.33 A. The asymmetric unit consists of a single strand or four base pairs. Two strands, related by a crystallographic dyad axis, coil about each other to form a right-handed duplex. This octamer duplex has a mean helix rotation of 32 degrees, 11.3 base pairs per turn, an average rise of 3.1 A, C3'-endo furanose conformations, a shallow minor groove, and a deep major groove. Such averaged parameters suggest classification of the octamer as a member of the A-DNA family. However, the global parameters tend to mask variations in conformational parameters observed at the level of the base pairs. In particular, the central TpA (= TpA) step displays extensive interstrand purine-purine overlap and an unusual sugar-phosphate backbone conformation. These structural features may be directly related to certain sequence-specific protein-DNA interactions involving nucleases and repressors.
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[[Category: Langlois D'Estaintot B]]
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==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D93 OCA].
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==Reference==
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Structural variation in d(CTCTAGAG). Implications for protein-DNA interactions., Hunter WN, D'Estaintot BL, Kennard O, Biochemistry. 1989 Mar 21;28(6):2444-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2730875 2730875]
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[[Category: Estaintot, B Langlois D.]]
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[[Category: Hunter, W N.]]
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[[Category: Kennard, O.]]
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[[Category: A-dna]]
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[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:35:19 2008''
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STRUCTURAL VARIATION IN D(CTCTAGAG). IMPLICATIONS FOR PROTEIN-DNA INTERACTIONS

PDB ID 1d93

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